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anti-COL7A1 antibody :: Rabbit anti-Human COL7A1 Polyclonal Antibody

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Catalog # MBS9414275
Unit / Price
  0.1 mL  /  $255 +1 FREE 8GB USB
Product Name

COL7A1, Polyclonal Antibody

Popular Item
Also Known As

COL7A1 Antibody

Product Synonym Names
EBD1; EBR1; EBDCT
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Length
2944
OMIM
120120
3D Structure
ModBase 3D Structure for Q02388
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human
Specificity
The antibody detects endogenous levels of total COL7A1 protein.
Purity/Purification
Antigen affinity purification.
Form/Format
Rabbit IgG in pH7.3 PBS, 0.05% NaN3, 50% Glycerol.
Concentration
2 mg/ml (lot specific)
Immunogen Type
Peptide
Immunogen Description
Synthetic peptide corresponding to residues near the C terminal of human collagen, type VII, alpha 1
Target Name
COL7A1
Preparation and Storage
Store at -20 degree C
Other Notes
Small volumes of anti-COL7A1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-COL7A1 antibody
This gene encodes the alpha chain of type VII collagen. The type VII collagen fibril, composed of three identical alpha collagen chains, is restricted to the basement zone beneath stratified squamous epithelia. It functions as an anchoring fibril between the external epithelia and the underlying stroma. Mutations in this gene are associated with all forms of dystrophic epidermolysis bullosa. In the absence of mutations, however, an acquired form of this disease can result from an autoimmune response made to type VII collagen.
Product Categories/Family for anti-COL7A1 antibody
Applications Tested/Suitable for anti-COL7A1 antibody
Immunohistochemistry (IHC)
Application Notes for anti-COL7A1 antibody
Immunohistochemistry: 1:25-1:100

Immunohistochemistry (IHC) of anti-COL7A1 antibody
Immunohistochemical analysis of paraffin-embedded Human gastric cancer tissue using at dilution 1/25.
anti-COL7A1 antibody Immunohistochemistry (IHC) (IHC) image
Immunohistochemistry (IHC) of anti-COL7A1 antibody
Immunohistochemical analysis of paraffin-embedded Human thyroid cancer tissue using at dilution 1/25.
anti-COL7A1 antibody Immunohistochemistry (IHC) (IHC) image
NCBI/Uniprot data below describe general gene information for COL7A1. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
292,267 Da
NCBI Official Full Name
collagen alpha-1(VII) chain
NCBI Official Synonym Full Names
collagen, type VII, alpha 1
NCBI Official Symbol
COL7A1  [Similar Products]
NCBI Official Synonym Symbols
EBD1; EBR1; EBDCT; NDNC8
  [Similar Products]
NCBI Protein Information
collagen alpha-1(VII) chain
UniProt Protein Name
Collagen alpha-1(VII) chain
UniProt Synonym Protein Names
Long-chain collagen; LC collagen
UniProt Gene Name
COL7A1  [Similar Products]
UniProt Synonym Gene Names
LC collagen  [Similar Products]
UniProt Entry Name
CO7A1_HUMAN
NCBI Summary for COL7A1
This gene encodes the alpha chain of type VII collagen. The type VII collagen fibril, composed of three identical alpha collagen chains, is restricted to the basement zone beneath stratified squamous epithelia. It functions as an anchoring fibril between the external epithelia and the underlying stroma. Mutations in this gene are associated with all forms of dystrophic epidermolysis bullosa. In the absence of mutations, however, an acquired form of this disease can result from an autoimmune response made to type VII collagen. [provided by RefSeq, Jul 2008]
UniProt Comments for COL7A1
COL7A1: the alpha chain of type VII collagen, an extra-cellular basement membrane protein restricted to the zone beneath stratified squamous epithelia. Type VII collagen fibrils are composed of three identical alpha collagen chains. Forms anchoring fibrils, which may contribute to epithelial basement membrane organization and adherence by interacting with extracellular matrix (ECM) proteins such as type IV collagen. Dystrophic epidermolysis bullosa can result from defects in this protein or an autoimmune response made to type VII collagen. Homotrimer. Interacts with MIA3, facilitating its loading into transport carriers and subsequent secretion. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Inhibitor; Extracellular matrix; Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 3p21.1

Cellular Component: extracellular matrix; extracellular space; collagen type VII; endoplasmic reticulum lumen; extracellular region; basement membrane

Molecular Function: serine-type endopeptidase inhibitor activity; identical protein binding; protein binding

Biological Process: extracellular matrix disassembly; collagen catabolic process; extracellular matrix organization and biogenesis; epidermis development; cell adhesion

Disease: Transient Bullous Dermolysis Of The Newborn; Epidermolysis Bullosa Dystrophica, Autosomal Dominant; Nail Disorder, Nonsyndromic Congenital, 8; Epidermolysis Bullosa Dystrophica, Autosomal Recessive; Epidermolysis Bullosa Pruriginosa; Epidermolysis Bullosa Dystrophica, Pretibial; Epidermolysis Bullosa With Congenital Localized Absence Of Skin And Deformity Of Nails
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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