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anti-COL3A1 antibody :: Rabbit anti-Human Collagen Type III Polyclonal Antibody

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Catalog # MBS316303
Unit / Price
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  0.5 mL  /  $820 +1 FREE 8GB USB
anti-COL3A1 antibody
Product Name

Collagen Type III (COL3A1), Polyclonal Antibody

Full Product Name

Rabbit A' Human Collagen III

Product Synonym Names
Rabbit Antibody to Human Collagen Type III
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Chromosome Location
Chromosome: 2; NC_000002.11 (189839099..189877472). Location: 2q31
OMIM
100070
3D Structure
ModBase 3D Structure for P02461
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human
Specificity
Collagen Type III
Specific to human Collagen Type III. Does not crossreact with bovine, rat, mouse and pig Collagen (tested by IFA).
Crossreactivity: Human collagen type III - 100%
Human collagen type I, IV - <1.0%
Human collagen type II, V -
Purity/Purification
Column chromatography
Form/Format
Purified, Lyophilized
Reconstitute with 0.5ml of deionized water.
Immunogen
Collagen type III extracted and purified from Human Placenta
Buffer
Not applicable
Preservative
No
Lyophilized
Yes
Important Note
Centrifuge before opening to ensure complete recovery of vial contents.
Preparation and Storage
Lyophilized: Store (up to 24 months) at 2 to 8 degree C or longer at -20 degree C.
Reconstituted: Store (up to 6 months) at -20 degree C. Aliquot to avoid multiple freeze/thaw cycles.
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Other Notes
Small volumes of anti-COL3A1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-COL3A1 antibody
EIA/ELISA, Immunofluorescence Assay, Radioimmunoassay
NCBI/Uniprot data below describe general gene information for COL3A1. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
138,564 Da[Similar Products]
NCBI Official Full Name
collagen, type III, alpha 1 (Ehlers-Danlos syndrome type IV, autosomal dominant), isoform CRA_b
NCBI Official Synonym Full Names
collagen, type III, alpha 1
NCBI Official Symbol
COL3A1  [Similar Products]
NCBI Official Synonym Symbols
EDS4A; FLJ34534
  [Similar Products]
NCBI Protein Information
collagen alpha-1(III) chain; collagen alpha-1(III) chain; collagen, fetal; OTTHUMP00000163485; alpha1 (III) collagen; Ehlers-Danlos syndrome type IV, autosomal dominant
UniProt Protein Name
Collagen alpha-1(III) chain
Protein Family
UniProt Gene Name
COL3A1  [Similar Products]
UniProt Entry Name
CO3A1_HUMAN
NCBI Summary for COL3A1
This gene encodes the pro-alpha1 chains of type III collagen, a fibrillar collagen that is found in extensible connective tissues such as skin, lung, uterus, intestine and the vascular system, frequently in association with type I collagen. Mutations in this gene are associated with Ehlers-Danlos syndrome types IV, and with aortic and arterial aneurysms. Two transcripts, resulting from the use of alternate polyadenylation signals, have been identified for this gene. [provided by R. Dalgleish]
UniProt Comments for COL3A1
Function: Collagen type III occurs in most soft connective tissues along with type I collagen.

Subunit structure: Trimers of identical alpha 1(III) chains. The chains are linked to each other by interchain disulfide bonds. Trimers are also cross-linked via hydroxylysines.

Subcellular location: Secreted › extracellular space › extracellular matrix

Post-translational modification: Proline residues at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains.O-linked glycan consists of a Glc-Gal disaccharide bound to the oxygen atom of a post-translationally added hydroxyl group.

Involvement in disease: Defects in COL3A1 are a cause of Ehlers-Danlos syndrome type 3 (EDS3) [

MIM:130020]; also known as benign hypermobility syndrome. EDS is a connective tissue disorder characterized by hyperextensible skin, atrophic cutaneous scars due to tissue fragility and joint hyperlaxity. EDS3 is a form of Ehlers-Danlos syndrome characterized by marked joint hyperextensibility without skeletal deformity. Ref.44Defects in COL3A1 are the cause of Ehlers-Danlos syndrome type 4 (EDS4) [

MIM:130050]. EDS is a connective tissue disorder characterized by hyperextensible skin, atrophic cutaneous scars due to tissue fragility and joint hyperlaxity. EDS4 is the most severe form of the disease. It is characterized by the joint and dermal manifestations as in other forms of the syndrome, characteristic facial features (acrogeria) in most patients, and by proneness to spontaneous rupture of bowel and large arteries. The vascular complications may affect all anatomical areas. Ref.30 Ref.31 Ref.32 Ref.33 Ref.34 Ref.35 Ref.37 Ref.38 Ref.39 Ref.40 Ref.41 Ref.43 Ref.45 Ref.46 Ref.47 Ref.48 Ref.49 Ref.50 Ref.51 Ref.52 Ref.53 Ref.55 Ref.56 Ref.57 Ref.58 Ref.60Defects in COL3A1 are a cause of susceptibility to aortic aneurysm abdominal (AAA) [

MIM:100070]. AAA is a common multifactorial disorder characterized by permanent dilation of the abdominal aorta, usually due to degenerative changes in the aortic wall. Histologically, AAA is characterized by signs of chronic inflammation, destructive remodeling of the extracellular matrix, and depletion of vascular smooth muscle cells. Ref.27 Ref.29 Ref.36

Sequence similarities: Belongs to the fibrillar collagen family.Contains 1 fibrillar collagen NC1 domain.Contains 1 VWFC domain.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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