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anti-COMMD1 antibody :: Rabbit anti-Human COMMD1 Polyclonal Antibody

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Catalog # MBS7043683
Unit / Price
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  0.05 mL  /  $120 +1 FREE 8GB USB
  0.1 mL  /  $160 +1 FREE 8GB USB
Product Name

COMMD1, Polyclonal Antibody

Popular Item
Full Product Name

COMMD1 Antibody

Product Synonym Names
COMM domain-containing protein 1; Protein Murr1; COMMD1; C2orf5; MURR1
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
OMIM
607238
3D Structure
ModBase 3D Structure for Q8N668
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Purity/Purification
Antigen Affinity Purified
Form/Format
Liquid
Species
Human
Immunogen
Recombinant human COMM domain-containing protein 1 protein (1-190AA)
Conjugate
Non-conjugated
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Santa Cruz Alternative
Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-107497 / sc-107500 / sc-107498 / sc-98286
Preparation and Storage
Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Other Notes
Small volumes of anti-COMMD1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-COMMD1 antibody
Proposed scaffold protein that is implicated in diverse physiological processes and whose function may be in part linked to its ability to regulate ubiquitination of specific cellular proteins. Can modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes by displacing CAND1; in vitro promotes CRL E3 activity and dissociates CAND1 from CUL1 and CUL2 (PubMed:21778237). Promotes ubiquitination of NF-kappa-B subunit RELA and its subsequent proteasomal degradation. Down-regulates NF-kappa-B activity (PubMed:15799966, PubMed:17183367, PubMed:20048074). Involved in the regulation of membrane expression and ubiquitination of SLC12A2 (PubMed:23515529). Modulates Na(+) transport in epithelial cells by regulation of apical cell surface expression of amiloride-sensitive sodium channel (ENaC) subunits and by promoting their ubiquitination presumably involving NEDD4L. Promotes the localization of SCNN1D to recycling endosomes (PubMed:14645214, PubMed:20237237, PubMed:21741370). Promotes CFTR cell surface expression through regulation of its ubiquitination (PubMed:21483833). Down-regulates SOD1 activity by interfering with its homodimerization (PubMed:20595380). Plays a role in copper ion homeostasis. Involved in copper-dependent ATP7A trafficking between the trans-Golgi network and vesicles in the cell periphery; the function is proposed to depend on its association within the CCC complex and cooperation with the WASH complex on early endosomes (PubMed:25355947). Can bind one copper ion per monomer (PubMed:17309234). May function to facilitate biliary copper excretion within hepatocytes. Binds to phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) (PubMed:18940794). Involved in the regulation of HIF1A-mediated transcription; competes with ARNT/Hif-1-beta for binding to HIF1A resulting in decreased DNA binding and impaired transcriptional activation by HIF-1 (PubMed:20458141).
Applications Tested/Suitable for anti-COMMD1 antibody
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP)

Western Blot (WB) of anti-COMMD1 antibody
Western blot
All lanes:  COMMD1antibody at 5.36ug/ml
Lane 1 : A549 whole cell lysate
Lane 2 : Jurkat whole cell lysate
Lane 3 : MCF7 whole cell lysate
Lane 4 : Hela whole cell lysate
Lane 5 : HepG-2 whole cell lysate
Secondary
Goat polyclonal to Rabbit IgG at 1/10000 dilution
Predicted band size: 22,18 kDa
Observed band size: 21 kDa

anti-COMMD1 antibody Western Blot (WB) (WB) image
Immunohistochemistry (IHC) of anti-COMMD1 antibody
Immunohistochemistry of paraffin-embedded human liver cancer using MBS7043683 at dilution 1:100
anti-COMMD1 antibody Immunohistochemistry (IHC) (IHC) image
Immunohistochemistry (IHC) of anti-COMMD1 antibody
Immunohistochemistry of paraffin-embedded human adrenal gland tissue using MBS7043683 at dilution 1:100
anti-COMMD1 antibody Immunohistochemistry (IHC) (IHC) image
Immunoprecipitation (IP) of anti-COMMD1 antibody
Immunoprecipitating COMMD1 in HepG2 whole cell lysate
Lane 1: Rabbit monoclonal IgG(1ug) instead of MBS7043683 in HepG2 whole cell lysate. For western blotting, a HRP-conjugated anti-rabbit IgG, specific to the non-reduced form of IgG was used as the Secondary antibody (1/50000)
Lane 2: MBS7043683(4ug)+ HepG2 whole cell lysate(500ug)
Lane 3: HepG2 whole cell lysate (20ug)

anti-COMMD1 antibody Immunoprecipitation (IP) (IP) image
NCBI/Uniprot data below describe general gene information for COMMD1. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
17,665 Da
NCBI Official Full Name
COMM domain-containing protein 1 isoform 1
NCBI Official Synonym Full Names
copper metabolism domain containing 1
NCBI Official Symbol
COMMD1  [Similar Products]
NCBI Official Synonym Symbols
MURR1; C2orf5
  [Similar Products]
NCBI Protein Information
COMM domain-containing protein 1
UniProt Protein Name
COMM domain-containing protein 1
UniProt Synonym Protein Names
Protein Murr1
UniProt Gene Name
COMMD1  [Similar Products]
UniProt Synonym Gene Names
C2orf5; MURR1  [Similar Products]
UniProt Entry Name
COMD1_HUMAN
NCBI Summary for COMMD1
COMMD1 is a regulator of copper homeostasis, sodium uptake, and NF-kappa-B (see MIM 164011) signaling (de Bie et al., 2005 [PubMed 16267171]).[supplied by OMIM, Sep 2009]
UniProt Comments for COMMD1
COMMD1: Promotes ubiquitination of NF-kappa-B subunit RELA and its subsequent proteasomal degradation. Down-regulates NF-kappa-B activity. Down-regulates SOD1 activity by interfering with its homodimerization. Plays a role in copper ion homeostasis. Can bind one copper ion per monomer. May function to facilitate biliary copper excretion within hepatocytes.

Protein type: Inhibitor

Chromosomal Location of Human Ortholog: 2p15

Cellular Component: Cul2-RING ubiquitin ligase complex; cytoplasm; early endosome; nucleoplasm; nucleus; recycling endosome

Molecular Function: copper ion binding; identical protein binding; phosphatidylinositol-3,4,5-triphosphate binding; phosphatidylinositol-3,4-bisphosphate binding; phosphatidylinositol-4,5-bisphosphate binding; protein binding; protein homodimerization activity

Biological Process: copper ion homeostasis; Golgi to plasma membrane transport; inhibition of NF-kappaB transcription factor; plasma membrane to endosome transport; positive regulation of protein ubiquitination; regulation of proteasomal ubiquitin-dependent protein catabolic process
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Pathways associated with anti-COMMD1 antibody
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