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anti-CTGF antibody :: Rabbit anti-Human CTGF CTGF Polyclonal Antibody

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Catalog # MBS535951
Unit / Price
  0.05 mg  /  $310 +1 FREE 8GB USB
  0.1 mg  /  $390 +1 FREE 8GB USB
  1 mg  /  $3,430 +4 FREE 8GB USB
anti-CTGF antibody
Product Name

CTGF, Polyclonal Antibody

Also Known As

CTGF antibody

Product Synonym Names
Polyclonal CTGF; Anti-CTGF; CCN2; HCS24; Hypertrophic chondrocyte-specific 24; Connective Tissue Growth Factor
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Length
349
OMIM
121009
3D Structure
ModBase 3D Structure for P29279
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human CTGF
Form/Format
Lyophilized from PBS, pH 7.2.
Biological Significance
CTGF is a member of the CCN family of secreted cysteine rich regulatory proteins and is the major mitogenic and chemoattractant protein produced by umbilical vein and vascular endothelial cells. CTGF stimulates the proliferation and differentiation of chondrocytes, induces angiogenesis, promotes cell adhesion of fibroblasts, endothelial, and epithelial cells, and binds to IGF, TGF beta1, and BMP-4.
Immunogen
CTGF antibody was raised in rabbit using highly pure recombinant human CTGF as the immunogen.
Preparation and Storage
Store at -20 degree C until reconstitution. Following reconstitution product may be stored at 4 degree C in the short term. For long term storage aliquot and freeze at -20 degree C. Avoid repeated freeze/thaw cycles.
Other Notes
Small volumes of anti-CTGF antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-CTGF antibody
Affinity purified Rabbit polyclonal CTGF antibody
Applications Tested/Suitable for anti-CTGF antibody
ELISA (EIA), Inhibition, Western Blot (WB)
Application Notes for anti-CTGF antibody
ELISA: 0.5-2 ug/ml
Inhibition: 6-9 ug/ml
WB: 0.1-0.2 ug/ml
NCBI/Uniprot data below describe general gene information for CTGF. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
11.2 kDa (predicted detection band MW)
NCBI Official Full Name
connective tissue growth factor
NCBI Official Synonym Full Names
connective tissue growth factor
NCBI Official Symbol
NCBI Official Synonym Symbols
CCN2; NOV2; HCS24; IGFBP8
  [Similar Products]
NCBI Protein Information
connective tissue growth factor
UniProt Protein Name
Connective tissue growth factor
UniProt Synonym Protein Names
CCN family member 2; Hypertrophic chondrocyte-specific protein 24; Insulin-like growth factor-binding protein 8; IBP-8; IGF-binding protein 8; IGFBP-8
UniProt Gene Name
UniProt Synonym Gene Names
CCN2; HCS24; IGFBP8; IBP-8; IGF-binding protein 8; IGFBP-8  [Similar Products]
UniProt Entry Name
CTGF_HUMAN
NCBI Summary for CTGF
The protein encoded by this gene is a mitogen that is secreted by vascular endothelial cells. The encoded protein plays a role in chondrocyte proliferation and differentiation, cell adhesion in many cell types, and is related to platelet-derived growth factor. Certain polymorphisms in this gene have been linked with a higher incidence of systemic sclerosis. [provided by RefSeq, Nov 2009]
UniProt Comments for CTGF
CTGF: Major connective tissue mitoattractant secreted by vascular endothelial cells. Promotes proliferation and differentiation of chondrocytes. Mediates heparin- and divalent cation-dependent cell adhesion in many cell types including fibroblasts, myofibroblasts, endothelial and epithelial cells. Enhances fibroblast growth factor-induced DNA synthesis. Belongs to the CCN family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted; Cell adhesion; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 6q23.1

Cellular Component: Golgi apparatus; proteinaceous extracellular matrix; extracellular space; cis-Golgi network; intracellular membrane-bound organelle; perinuclear region of cytoplasm; plasma membrane; extracellular region; cell cortex; cytosol

Molecular Function: heparin binding; integrin binding; insulin-like growth factor binding; protein binding; growth factor activity; fibronectin binding

Biological Process: response to peptide hormone stimulus; epidermis development; response to anoxia; cell-matrix adhesion; positive regulation of collagen biosynthetic process; positive regulation of JNK cascade; positive regulation of caspase activity; cellular lipid metabolic process; response to estradiol stimulus; cell-cell signaling; positive regulation of stress fiber formation; positive regulation of cell proliferation; tissue homeostasis; response to wounding; response to glucose stimulus; regulation of cell growth; angiogenesis; cell differentiation; cell adhesion; cartilage condensation; positive regulation of cell activation; integrin-mediated signaling pathway; transcription initiation from RNA polymerase II promoter; ossification; cell migration; fibroblast growth factor receptor signaling pathway; organ senescence; response to mineralocorticoid stimulus; response to amino acid stimulus; gene expression; positive regulation of protein amino acid phosphorylation; regulation of chondrocyte differentiation; positive regulation of cell differentiation; lung development
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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