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anti-CX3CR1 antibody :: Rabbit anti-Human CX3CR1 Polyclonal Antibody

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Catalog # MBS150820
Unit / Price
  0.1 mg  /  $375 +1 FREE 8GB USB
Product Name

CX3CR1, Polyclonal Antibody

Popular Item
Also Known As

CX3CR1 Antibody

Product Synonym Names
CX3CR1; V28; CCRL1; GPR13; CMKDR1; GPRV28; CMKBRL1; CX3C chemokine receptor 1; Beta chemokine receptor-like 1; C-X3-C CKR-1; chemokine (C-X3-C motif) receptor 1
Antibody/Peptide Pairs
CX3CR1 peptide (MBS152040) is used for blocking the activity of CX3CR1 antibody (MBS150820)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Length
355
OMIM
phenotype 613784
3D Structure
ModBase 3D Structure for P49238
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Specificity
At least two isoforms of CX3CR1 are known to exist.
Purity/Purification
CX3CR1 Antibody is affinity chromatography purified via peptide column.
Form/Format
Liquid
Concentration
1 mg/mL (lot specific)
Conjugate
Unconjugated
Immunogen
CX3CR1 antibody was raised against a peptide corresponding to amino acids in a extracellular loop of human CX3CR1.
Buffer
CX3CR1 Antibody is supplied in PBS containing 0.02% sodium azide.
Preparation and Storage
CX3CR1 antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Other Notes
Small volumes of anti-CX3CR1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-CX3CR1 antibody
CX3CR1 Antibody: CX3CR1 is one of the chemokine receptors that are required as coreceptors for HIV infection. The genes encoding human, mouse, and rat CX3CR1 were cloned and designated V28 and CMKBRL1, CX3CR1, and RBS11, respectively. The encoded seven transmembrane protein was initially identified as the receptor for the transmembrane molecule fractalkine, and renamed CX3CR1. CX3CR1 is known to serve as a coreceptor for HIV-1 and HIV-2 envelope fusion and virus infection, which can be inhibited by fractokine. CX3CR1 mediates leukocyte migration and adhesion. CX3CR1 is expressed in a variety of human tissues and cell lines.
Applications Tested/Suitable for anti-CX3CR1 antibody
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
Application Notes for anti-CX3CR1 antibody
CX3CR1 antibody can be used for detection of CX3CR1 by Western blot at 0.5 mug/mL. Antibody can also be used for immunohistochemistry starting at 10 mug/mL. For immunofluorescence start at 20 mug/mL.

Western Blot (WB) of anti-CX3CR1 antibody
Western blot analysis of CX3CR1 in THP-1 cell lysate with CX3CR1 antibody at 1 μg/mL in (A) the absence and (B) the presence of blocking peptide.
anti-CX3CR1 antibody Western Blot (WB) (WB) image
Immunohistochemistry (IHC) of anti-CX3CR1 antibody
Immunohistochemistry of CX3CR1 in human spleen cells with CX3CR1 antibody at 10 μg/mL.
anti-CX3CR1 antibody Immunohistochemistry (IHC) (IHC) image
Immunofluorescence (IF) of anti-CX3CR1 antibody
Immunofluorescence of CX3CR1 in THP-1 cells with CX3CR1 antibody at 20 μg/mL.
anti-CX3CR1 antibody Immunofluorescence (IF) image
NCBI/Uniprot data below describe general gene information for CX3CR1. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
Predicted: 39; 43 kDa

Observed: 50 kDa
NCBI Official Full Name
CX3C chemokine receptor 1 isoform b
NCBI Official Synonym Full Names
chemokine (C-X3-C motif) receptor 1
NCBI Official Symbol
CX3CR1  [Similar Products]
NCBI Official Synonym Symbols
V28; CCRL1; GPR13; CMKDR1; GPRV28; CMKBRL1
  [Similar Products]
NCBI Protein Information
CX3C chemokine receptor 1; CMK-BRL1; CMK-BRL-1; C-X3-C CKR-1; fractalkine receptor; G protein-coupled receptor 13; G-protein coupled receptor 13; chemokine (C-X3-C) receptor 1; beta chemokine receptor-like 1; chemokine (C-C) receptor-like 1
UniProt Protein Name
CX3C chemokine receptor 1
UniProt Synonym Protein Names
Beta chemokine receptor-like 1; CMK-BRL-1; CMK-BRL1; Fractalkine receptor; G-protein coupled receptor 13; V28
Protein Family
UniProt Gene Name
CX3CR1  [Similar Products]
UniProt Synonym Gene Names
CMKBRL1; GPR13; C-X3-C CKR-1; CX3CR1; CMK-BRL1  [Similar Products]
UniProt Entry Name
CX3C1_HUMAN
NCBI Summary for CX3CR1
Fractalkine is a transmembrane protein and chemokine involved in the adhesion and migration of leukocytes. The protein encoded by this gene is a receptor for fractalkine. The encoded protein also is a coreceptor for HIV-1, and some variations in this gene lead to increased susceptibility to HIV-1 infection and rapid progression to AIDS. Four transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jan 2010]
UniProt Comments for CX3CR1
CX3CR1: Receptor for the CX3C chemokine fractalkine and mediates both its adhesive and migratory functions. Acts as coreceptor with CD4 for HIV-1 virus envelope protein (in vitro). Isoform 2 and isoform 3 seem to be more potent HIV-1 coreceptors than isoform 1. Defects in CX3CR1 are a cause of susceptibility to age- related macular degeneration type 12 (ARMD12). ARMD12 is a form of age-related macular degeneration, a multifactorial eye disease and the most common cause of irreversible vision loss in the developed world. In most patients, the disease is manifest as ophthalmoscopically visible yellowish accumulations of protein and lipid that lie beneath the retinal pigment epithelium and within an elastin-containing structure known as Bruch membrane. Belongs to the G-protein coupled receptor 1 family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Receptor, GPCR; Membrane protein, integral; Cell adhesion; Receptor, cytokine; GPCR, family 1; Membrane protein, multi-pass; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 3p21.3

Cellular Component: neuron projection; integral to plasma membrane; perinuclear region of cytoplasm; plasma membrane

Molecular Function: protein binding; chemokine receptor activity; C-X3-C chemokine receptor activity

Biological Process: G-protein coupled receptor protein signaling pathway; positive regulation of angiogenesis; negative regulation of angiogenesis; cerebral cortex cell migration; viral reproduction; response to wounding; cellular defense response; chemotaxis; cell adhesion; macrophage chemotaxis; negative regulation of cell migration; microglial cell activation during immune response

Disease: Macular Degeneration, Age-related, 12; Coronary Heart Disease, Susceptibility To, 1; Human Immunodeficiency Virus Type 1, Susceptibility To
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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