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anti-IL8RA antibody :: Goat CXCR1 Polyclonal Antibody

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Catalog # MBS422389
Unit / Price
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  0.1 mg  /  $225 +1 FREE 8GB USB
anti-IL8RA antibody
Product Name

CXCR1 (IL8RA), Polyclonal Antibody

Full Product Name

Goat anti-CXCR1 Antibody

Product Synonym Names
Goat Anti-CXCR1 (aa26-38) Antibody; IL8RA; interleukin 8 receptor, alpha; C-C; C-C-CKR-1; CD128; CD181; CDw128a; CKR-1; CMKAR1; CXCR1; IL8R1; IL8RBA; IL-8 receptor type 1; chemokine (C-X-C motif) receptor 1; high affinity interleukin-8 receptor A; interleukin 8 receptor alpha; interleukin-8; C-C antibody; C-C-CKR-1 antibody; CD128 antibody; CD181 antibody; CDw128a antibody; chemokine (C-X-C motif) receptor 1 antibody; CKR-1 antibody; CMKAR1 antibody; CXCR1 antibody; IL-8 receptor type 1 antibody; IL8R1 antibody; IL8RBA antibody; interleukin 8 receptor alpha antibody; interleukin 8 receptor; alpha antibody; IL8RA antibody
Product Synonym Gene Name
Antibody/Peptide Pairs
CXCR1 peptide (MBS427310) is used for blocking the activity of CXCR1 antibody (MBS422389)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence
SKEFLARHRV TSY
OMIM
146929
Clonality
Polyclonal
Host
Goat
Species Reactivity
Expected from sequence similarity: Human
Purity/Purification
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Form/Format
Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
Concentration
100ug specific antibody in 200ul (lot specific)
Immunogen
Peptide with sequence C-SKEFLARHRVTSY, from the C Terminus of the protein sequence according to NP_000625.1.
Epitope
C Terminus
Preparation and Storage
Aliquot and store at -20 degree C. Minimize freezing and thawing.
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Other Notes
Small volumes of anti-IL8RA antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-IL8RA antibody
Peptide ELISA (EIA)
Application Notes for anti-IL8RA antibody
Peptide ELISA: Antibody detection limit dilution 1: 1000.
Western Blot: Preliminary experiments gave an approx 100kDa band in Human Peripharal Blood Mononucleocytes lysates after 1ug/ml antibody staining. Please note that currently we cannot find an explanation in the literature for the band we observe given the calculated size of 39.8kDa according to NP_000625.1. The 100kDa band was successfully blocked by incubation with the immunizing peptide.
NCBI/Uniprot data below describe general gene information for IL8RA. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
39,791 Da
NCBI Official Full Name
C-X-C chemokine receptor type 1
NCBI Official Synonym Full Names
C-X-C motif chemokine receptor 1
NCBI Official Symbol
CXCR1  [Similar Products]
NCBI Official Synonym Symbols
C-C; CD128; CD181; CKR-1; IL8R1; IL8RA; CMKAR1; IL8RBA; CDw128a; C-C-CKR-1
  [Similar Products]
NCBI Protein Information
C-X-C chemokine receptor type 1
UniProt Protein Name
C-X-C chemokine receptor type 1
UniProt Synonym Protein Names
CDw128a; High affinity interleukin-8 receptor A; IL-8R A; IL-8 receptor type 1; CD_antigen: CD181
UniProt Gene Name
CXCR1  [Similar Products]
UniProt Synonym Gene Names
CMKAR1; IL8RA; CXC-R1; CXCR-1; IL-8R A  [Similar Products]
UniProt Entry Name
CXCR1_HUMAN
NCBI Summary for IL8RA
The protein encoded by this gene is a member of the G-protein-coupled receptor family. This protein is a receptor for interleukin 8 (IL8). It binds to IL8 with high affinity, and transduces the signal through a G-protein activated second messenger system. Knockout studies in mice suggested that this protein inhibits embryonic oligodendrocyte precursor migration in developing spinal cord. This gene, IL8RB, a gene encoding another high affinity IL8 receptor, as well as IL8RBP, a pseudogene of IL8RB, form a gene cluster in a region mapped to chromosome 2q33-q36. [provided by RefSeq, Jul 2008]
UniProt Comments for IL8RA
IL8RA: Receptor to interleukin-8, which is a powerful neutrophils chemotactic factor. Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activate a phosphatidylinositol-calcium second messenger system. This receptor binds to IL-8 with a high affinity and to MGSA (GRO) with a low affinity. Belongs to the G-protein coupled receptor 1 family.

Protein type: Membrane protein, integral; Receptor, cytokine; Membrane protein, multi-pass; GPCR, family 1; Receptor, GPCR

Chromosomal Location of Human Ortholog: 2q35

Cellular Component: integral to membrane; membrane; plasma membrane

Molecular Function: chemokine receptor activity; G-protein coupled receptor activity; interleukin-8 binding; interleukin-8 receptor activity

Biological Process: cell surface receptor linked signal transduction; chemotaxis; dendritic cell chemotaxis; G-protein coupled receptor protein signaling pathway; inflammatory response; receptor internalization

Disease: Human Immunodeficiency Virus Type 1, Susceptibility To
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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