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anti-CYP2C19 antibody :: Rabbit anti-Human CYP2C19 Polyclonal Antibody

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Catalog # MBS2539121
Unit / Price
Scan QR to view Datasheet
  0.02 mL  /  $110 +1 FREE 8GB USB
  0.06 mL  /  $150 +1 FREE 8GB USB
  0.12 mL  /  $225 +1 FREE 8GB USB
  0.2 mL  /  $360 +1 FREE 8GB USB
Western Blot (WB)
Product Name

CYP2C19, Polyclonal Antibody

Popular Item
Full Product Name

CYP2C19 Polyclonal Antibody

Product Synonym Names
CYP2C19; Cytochrome P450 2C19; (R)-limonene 6-monooxygenase; (S)-limonene 6-monooxygenase; (S)-limonene 7-monooxygenase; CYPIIC17; CYPIIC19; Cytochrome P450-11A; Cytochrome P450-254C; Mephenytoin 4-hydroxylase
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
OMIM
124020
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Purity/Purification
Antigen Affinity Purified
Concentration
1 mg/ml (lot specific)
Immunogen
Synthesized peptide derived from the Internal region of human CYP2C19.
Buffer
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Santa Cruz Alternative
Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-23436 / sc-23435
Preparation and Storage
Store at -20 degree C. Avoid freeze / thaw cycles.
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Other Notes
Small volumes of anti-CYP2C19 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Product Categories/Family for anti-CYP2C19 antibody
Applications Tested/Suitable for anti-CYP2C19 antibody
Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), ELISA (EIA)
Application Notes for anti-CYP2C19 antibody
WB: 1:500-1:2000, IHC: 1:50-1:200, IF: 1:50-1:100, ELISA: 1:5000-1:20000

Western Blot (WB) of anti-CYP2C19 antibody
Western Blot analysis of Mouse brain using CYP2C19 Polyclonal Antibody at dilution of 1:1000.
anti-CYP2C19 antibody Western Blot (WB) (WB) image
NCBI/Uniprot data below describe general gene information for CYP2C19. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
Calculated MW: 56
Observed MW: 56
NCBI Official Full Name
cytochrome P450 2C19
NCBI Official Synonym Full Names
cytochrome P450 family 2 subfamily C member 19
NCBI Official Symbol
CYP2C19  [Similar Products]
NCBI Official Synonym Symbols
CPCJ; CYP2C; P450C2C; CYPIIC17; CYPIIC19; P450IIC19
  [Similar Products]
NCBI Protein Information
cytochrome P450 2C19
UniProt Protein Name
Cytochrome P450 2C19
UniProt Synonym Protein Names
(R)-limonene 6-monooxygenase (EC:1.14.13.80); (S)-limonene 6-monooxygenase (EC:1.14.13.48); (S)-limonene 7-monooxygenase (EC:1.14.13.49); CYPIIC17; CYPIIC19; Cytochrome P450-11A; Cytochrome P450-254C; Mephenytoin 4-hydroxylase
Protein Family
UniProt Gene Name
CYP2C19  [Similar Products]
UniProt Entry Name
CP2CJ_HUMAN
NCBI Summary for CYP2C19
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is known to metabolize many xenobiotics, including the anticonvulsive drug mephenytoin, omeprazole, diazepam and some barbiturates. Polymorphism within this gene is associated with variable ability to metabolize mephenytoin, known as the poor metabolizer and extensive metabolizer phenotypes. The gene is located within a cluster of cytochrome P450 genes on chromosome 10q24. [provided by RefSeq, Jul 2008]
UniProt Comments for CYP2C19
CYP2C19: Responsible for the metabolism of a number of therapeutic agents such as the anticonvulsant drug S-mephenytoin, omeprazole, proguanil, certain barbiturates, diazepam, propranolol, citalopram and imipramine. Belongs to the cytochrome P450 family.

Protein type: EC 1.14.13.49; Oxidoreductase; Lipid Metabolism - linoleic acid; Xenobiotic Metabolism - metabolism by cytochrome P450; Xenobiotic Metabolism - drug metabolism - cytochrome P450; EC 1.14.13.80; Cofactor and Vitamin Metabolism - retinol; Lipid Metabolism - arachidonic acid; Secondary Metabolites Metabolism - limonene and pinene degradation; EC 1.14.13.48

Chromosomal Location of Human Ortholog: 10q24

Cellular Component: endoplasmic reticulum membrane; intracellular membrane-bound organelle

Molecular Function: (S)-limonene 6-monooxygenase activity; (S)-limonene 7-monooxygenase activity; arachidonic acid epoxygenase activity; enzyme binding; heme binding; iron ion binding; monooxygenase activity; oxidoreductase activity; oxygen binding; steroid hydroxylase activity

Biological Process: arachidonic acid metabolic process; drug metabolic process; epoxygenase P450 pathway; exogenous drug catabolic process; heterocycle metabolic process; monoterpenoid metabolic process; steroid metabolic process; xenobiotic metabolic process

Disease: Drug Metabolism, Poor, Cyp2c19-related
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Organs/Tissues associated with anti-CYP2C19 antibody
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