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anti-CYTH3 antibody :: Rabbit anti-Human CYTH3 Polyclonal Antibody

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Catalog # MBS9608240
Unit / Price
  0.1 mL  /  $255 +1 FREE 8GB USB
  0.2 mL  /  $295 +1 FREE 8GB USB
Western Blot (WB)
Product Name

CYTH3, Polyclonal Antibody

Popular Item
Also Known As

CYTH3 Antibody

Product Synonym Names
CYTH3; ARF nucleotide-binding site opener 3; ARNO3; ARNO3 protein; CYH3_HUMAN; Cyth3; Cytohesin-3; General receptor of phosphoinositides 1; Grp1; PH; PH, SEC7 and coiled-coil domain-containing protein 3; Protein ARNO3; PSCD3; SEC7 and coiled-coil domain-containing protein 3; SEC7 homolog C; Sec7-3; Sec7c
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Length
399
3D Structure
ModBase 3D Structure for O43739
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Specificity
CYTH3 antibody detects endogenous levels of total CYTH3
Purity/Purification
The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin.
Form/Format
Liquid
Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration
1mg/ml (lot specific)
Immunogen
A synthesized peptide derived from human CYTH3
Subcellular Location
Cell Membrane
Tissue Specificity
Almost absent from liver, thymus and peripheral blood lymphocytes.
Conjugation
Unconjugated
Preparation and Storage
Store at -20 degree C. Stable for 12 months from date of receipt.
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Supply Chain Verification
Manufactured in a lab with traceable raw materials. Bulk orders can typically be prepared to the customer’s specifications, please inquire.
Other Notes
Small volumes of anti-CYTH3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-CYTH3 antibody
Function: Promotes guanine-nucleotide exchange on ARF1 and ARF6. Promotes the activation of ARF factors through replacement of GDP with GTP. Play a role in the epithelial polarization (By similarity).
Subunit Structure: Interacts with GRASP (By similarity). Interacts with ARF6 (PubMed:23940353). Interacts with FRMD4A (By similarity). Interacts with FRMD4B (By similarity).
Similarity: Binds via its PH domain to the inositol head group of phosphatidylinositol 3, 4, 5-trisphosphate.Autoinhibited by its C-terminal basic region.
Applications Tested/Suitable for anti-CYTH3 antibody
Western Blot (WB), ELISA (EIA)
Application Notes for anti-CYTH3 antibody
WB: 1:1000-3000

Western Blot (WB) of anti-CYTH3 antibody
Western blot analysis of CYTH3 using COLO205 whole lysates.
anti-CYTH3 antibody Western Blot (WB) (WB) image
NCBI/Uniprot data below describe general gene information for CYTH3. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
Observed: 46 kDa
Predicted: 47 kDa
NCBI Official Full Name
cytohesin-3
NCBI Official Synonym Full Names
cytohesin 3
NCBI Official Symbol
CYTH3  [Similar Products]
NCBI Official Synonym Symbols
GRP1; ARNO3; PSCD3; cytohesin-3
  [Similar Products]
NCBI Protein Information
cytohesin-3
UniProt Protein Name
Cytohesin-3
UniProt Synonym Protein Names
ARF nucleotide-binding site opener 3; Protein ARNO3; General receptor of phosphoinositides 1; Grp1; PH, SEC7 and coiled-coil domain-containing protein 3
Protein Family
UniProt Gene Name
CYTH3  [Similar Products]
UniProt Synonym Gene Names
Protein ARNO3; Grp1  [Similar Products]
NCBI Summary for CYTH3
This gene encodes a member of the PSCD (pleckstrin homology, Sec7 and coiled-coil domains) family. PSCD family members have identical structural organization that consists of an N-terminal coiled-coil motif, a central Sec7 domain, and a C-terminal pleckstrin homology (PH) domain. The coiled-coil motif is involved in homodimerization, the Sec7 domain contains guanine-nucleotide exchange protein (GEP) activity, and the PH domain interacts with phospholipids and is responsible for association of PSCDs with membranes. Members of this family appear to mediate the regulation of protein sorting and membrane trafficking. This encoded protein is involved in the control of Golgi structure and function, and it may have a physiological role in regulating ADP-ribosylation factor protein 6 (ARF) functions, in addition to acting on ARF1. [provided by RefSeq, Jul 2008]
UniProt Comments for CYTH3
Promotes guanine-nucleotide exchange on ARF1 and ARF6. Promotes the activation of ARF factors through replacement of GDP with GTP. Play a role in the epithelial polarization ().
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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