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anti-DKK4 antibody :: Rabbit anti-Human Dickkopf-related protein 4 Polyclonal Antibody

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Catalog # MBS1494927
Unit / Price
  0.05 mL  /  $120 +1 FREE 8GB USB
  0.1 mL  /  $160 +1 FREE 8GB USB
Product Name

Dickkopf-related protein 4 (DKK4), Polyclonal Antibody

Popular Item
Full Product Name

Rabbit anti-human Dickkopf-related protein 4 polyclonal Antibody(DKK4)

Product Synonym Names
Dickkopf-4; Dkk-4; hDkk-4; DKK4
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
OMIM
605417
3D Structure
ModBase 3D Structure for Q9UBT3
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Purity/Purification
Antigen Affinity Purified
Storage Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Conjugate
Non-conjugated
Immunogen
Recombinant human Dickkopf-related protein 4 protein (19-224aa)
Santa Cruz Alternative
Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-14962 / sc-14961 / sc-25519
Preparation and Storage
Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Other Notes
Small volumes of anti-DKK4 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-DKK4 antibody
Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease (By similarity).
Applications Tested/Suitable for anti-DKK4 antibody
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-DKK4 antibody
Recommended dilution: WB:1:500-2000
IHC:1:20-1:200

Western Blot (WB) of anti-DKK4 antibody
All lanes: Dickkopf-related protein 4 antibody at 8ug/ml
Lane 1:jurkat whole cell lysate
Lane 2:K562 whole cell lysate
Secondary
Goat polyclonal to rabbit at 1/10000 dilution
Predicted band size: 25kDa
Observed band size: 25kDa

anti-DKK4 antibody Western Blot (WB) (WB) image
Immunohistochemistry (IHC) of anti-DKK4 antibody
Immunohistochemistry of paraffin-embedded human breast cancer using MBS1494927 at dilution 1:100
anti-DKK4 antibody Immunohistochemistry (IHC) (IHC) image
Immunohistochemistry (IHC) of anti-DKK4 antibody
Immunohistochemistry of paraffin-embedded human liver using MBS1494927 at dilution 1:100
anti-DKK4 antibody Immunohistochemistry (IHC) (IHC) image
NCBI/Uniprot data below describe general gene information for DKK4. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
24,876 Da
NCBI Official Full Name
dickkopf-related protein 4
NCBI Official Synonym Full Names
dickkopf WNT signaling pathway inhibitor 4
NCBI Official Symbol
NCBI Official Synonym Symbols
DKK-4
  [Similar Products]
NCBI Protein Information
dickkopf-related protein 4
UniProt Protein Name
Dickkopf-related protein 4
Protein Family
UniProt Gene Name
UniProt Synonym Gene Names
Dickkopf-4; Dkk-4; hDkk-4  [Similar Products]
UniProt Entry Name
DKK4_HUMAN
NCBI Summary for DKK4
This gene encodes a protein that is a member of the dickkopf family. The secreted protein contains two cysteine rich regions and is involved in embryonic development through its interactions with the Wnt signaling pathway. Activity of this protein is modulated by binding to the Wnt co-receptor and the co-factor kremen 2. [provided by RefSeq, Jul 2008]
UniProt Comments for DKK4
DKK4: Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero- posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease. Belongs to the dickkopf family.

Protein type: Inhibitor; Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 8p11.2-p11.1

Cellular Component: extracellular region

Biological Process: multicellular organismal development; negative regulation of Wnt receptor signaling pathway; Wnt receptor signaling pathway
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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