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anti-DNA ligase 1 antibody :: Rabbit anti-Human DNA ligase 1 Polyclonal Antibody

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Catalog # MBS7005245
Unit / Price
  0.05 mg  /  $160 +1 FREE 8GB USB
  0.1 mg  /  $235 +1 FREE 8GB USB
Product Name

DNA ligase 1, Polyclonal Antibody

Popular Item
Also Known As

Rabbit anti-human DNA ligase 1 polyclonal Antibody

Product Synonym Names
DNA ligase I; Polydeoxyribonucleotide synthase [ATP] 1; LIG1
Product Synonym Gene Name
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Length
919
OMIM
126391
3D Structure
ModBase 3D Structure for P18858
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Purity/Purification
Caprylic Acid Ammonium Sulfate Precipitation purified
Form/Format
Liquid
Immunogen
Recombinant human DNA ligase 1 protein
Conjugation
Non-conjugated
Storage Buffer
Preservative: 0.03% Proclin 300; Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Santa Cruz Alternative
Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-20222 / sc-20224 / sc-366180
Preparation and Storage
Shipped at 4 degree C. Upon delivery, aliquot and store at -20 degree C or -80 degree C.
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Other Notes
Small volumes of anti-DNA ligase 1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-DNA ligase 1 antibody
DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.

LIG1 encodes DNA ligase I, with functions in DNA replication and the base excision repair process. Mutations in LIG1 that lead to DNA ligase I deficiency result in immunodeficiency and increased sensitivity to DNA-damaging agents.
Product Categories/Family for anti-DNA ligase 1 antibody
Applications Tested/Suitable for anti-DNA ligase 1 antibody
ELISA (EIA), Immunohistochemistry (IHC)
Application Notes for anti-DNA ligase 1 antibody
Recommended dilution: IHC: 1:20-1:200

Immunohistochemistry (IHC) of anti-DNA ligase 1 antibody
Immunohistochemistry of paraffin-embedded human placenta tissue using MBS7005245 at dilution 1:100
anti-DNA ligase 1 antibody Immunohistochemistry (IHC) (IHC) image
Immunofluorescence (IF) of anti-DNA ligase 1 antibody
Immunofluorescent analysis of A549 cells using MBS7005245 at a dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
anti-DNA ligase 1 antibody Immunofluorescence (IF) image
NCBI/Uniprot data below describe general gene information for DNA ligase 1. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
98,228 Da
NCBI Official Full Name
DNA ligase 1 isoform 1
NCBI Official Synonym Full Names
ligase I, DNA, ATP-dependent
NCBI Official Symbol
NCBI Protein Information
DNA ligase 1
UniProt Protein Name
DNA ligase 1
UniProt Synonym Protein Names
DNA ligase I; Polydeoxyribonucleotide synthase [ATP] 1
Protein Family
UniProt Gene Name
UniProt Entry Name
DNLI1_HUMAN
NCBI Summary for DNA ligase 1
This gene encodes a member of the ATP-dependent DNA ligase protein family. The encoded protein functions in DNA replication, recombination, and the base excision repair process. Mutations in this gene that lead to DNA ligase I deficiency result in immunodeficiency and increased sensitivity to DNA-damaging agents. Disruption of this gene may also be associated with a variety of cancers. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]
UniProt Comments for DNA ligase 1
LIG1: is an enzyme that functions in DNA replication and the base excision repair process. Mutations leading to DNA ligase I deficiency result in immunodeficiency and increased sensitivity to DNA-damaging agents.

Protein type: Ligase; EC 6.5.1.1; DNA repair, damage

Chromosomal Location of Human Ortholog: 19q13.2-q13.3

Cellular Component: Golgi apparatus; intracellular membrane-bound organelle; mitochondrion; nucleoplasm; nucleus

Molecular Function: ATP binding; DNA binding; DNA ligase (ATP) activity; DNA ligase activity; metal ion binding

Biological Process: anatomical structure morphogenesis; base-excision repair; cell division; DNA ligation; DNA ligation during DNA repair; DNA metabolic process; DNA repair; DNA strand elongation during DNA replication; double-strand break repair via nonhomologous end joining; mismatch repair; mitotic cell cycle; nucleotide-excision repair; nucleotide-excision repair, DNA gap filling; response to hydrogen peroxide; telomere maintenance; telomere maintenance via recombination; telomere maintenance via semi-conservative replication; transcription-coupled nucleotide-excision repair; V(D)J recombination
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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