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anti-DNMT3L antibody :: Rabbit anti-Human DNMT3L Polyclonal Antibody

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Catalog # MBS7051534
Unit / Price
  0.05 mg  /  $160 +1 FREE 8GB USB
  0.1 mg  /  $235 +1 FREE 8GB USB
Product Name

DNMT3L, Polyclonal Antibody

Popular Item
Also Known As

DNMT3L Antibody

Product Synonym Names
DNA (cytosine-5)-methyltransferase 3-like; DNMT3L
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Length
387
OMIM
AF194032 mRNA
3D Structure
ModBase 3D Structure for Q9UJW3
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Purity/Purification
>95%, Protein G purified
Form/Format
Liquid
Immunogen
Recombinant Human DNA (cytosine-5)-methyltransferase 3-like protein (1-234AA)
Preservative
0.03% Proclin 300
Constituents
50% Glycerol, 0.01M PBS, pH 7.4
Conjugation
Non-conjugated
Santa Cruz Alternative
Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-10239 / sc-10241 / sc-20705
Preparation and Storage
Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Other Notes
Small volumes of anti-DNMT3L antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-DNMT3L antibody
Catalytically inactive regulatory factor of DNA methyltransferases. It is essential for the function of DNMT3A and DNMT3B. Activates DNMT3A and DNMT3B by binding to their catalytic domain. Accelerates the binding of DNA and AdoMet to the methyltransferases and dissociates from the complex after DNA binding to the methyltransferases. Recognizes unmethylated histone H3 lysine 4 (H3K4) and induces de novo DNA methylation by recruitment or activation of DNMT3.
Applications Tested/Suitable for anti-DNMT3L antibody
ELISA (EIA), Immunofluorescence (IF)
Application Notes for anti-DNMT3L antibody
IF: 1: 50-1: 200

Immunofluorescence (IF) of anti-DNMT3L antibody
Immunofluorescent analysis of Hela cells using MBS7051534 at a dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
anti-DNMT3L antibody Immunofluorescence (IF) image
Western Blot (WB) of anti-DNMT3L antibody
Western Blot
Positive WB detected in: PC3 whole cell lysate,HepG2 whole cell lysate,A549 whole cell lysate
All lanes: DNMT3L antibody at 3.4ug/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 44 KDa
Observed band size: 44 KDa

anti-DNMT3L antibody Western Blot (WB) (WB) image
NCBI/Uniprot data below describe general gene information for DNMT3L. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
43,670 Da
NCBI Official Full Name
DNA (cytosine-5)-methyltransferase 3-like isoform 1
NCBI Official Synonym Full Names
DNA methyltransferase 3 like
NCBI Official Symbol
DNMT3L  [Similar Products]
NCBI Protein Information
DNA (cytosine-5)-methyltransferase 3-like
UniProt Protein Name
DNA (cytosine-5)-methyltransferase 3-like
UniProt Gene Name
DNMT3L  [Similar Products]
UniProt Entry Name
DNM3L_HUMAN
NCBI Summary for DNMT3L
CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a nuclear protein with similarity to DNA methyltransferases, but is not thought to function as a DNA methyltransferase as it does not contain the amino acid residues necessary for methyltransferase activity. However, it does stimulate de novo methylation by DNA cytosine methyltransferase 3 alpha and is thought to be required for the establishment of maternal genomic imprints. This protein also mediates transcriptional repression through interaction with histone deacetylase 1. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2012]
UniProt Comments for DNMT3L
Catalytically inactive regulatory factor of DNA methyltransferases. It is essential for the function of DNMT3A and DNMT3B. Activates DNMT3A and DNMT3B by binding to their catalytic domain. Accelerates the binding of DNA and AdoMet to the methyltransferases and dissociates from the complex after DNA binding to the methyltransferases. Recognizes unmethylated histone H3 lysine 4 (H3K4) and induces de novo DNA methylation by recruitment or activation of DNMT3.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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