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anti-DUSP16 antibody :: Rabbit anti-Human DUSP16 Polyclonal Antibody

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Catalog # MBS7045838
Unit / Price
  0.05 mL  /  $120 +1 FREE 8GB USB
  0.1 mL  /  $160 +1 FREE 8GB USB
Product Name

DUSP16, Polyclonal Antibody

Popular Item
Also Known As

DUSP16 Antibody

Product Synonym Names
Dual specificity protein phosphatase 16; Mitogen-activated protein kinase phosphatase 7; MAP kinase phosphatase 7; MKP-7; DUSP16; KIAA1700; MKP7
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Length
665
OMIM
607175
3D Structure
ModBase 3D Structure for Q9BY84
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Purity/Purification
Antigen Affinity Purified
Form/Format
Liquid
Species
Human
Immunogen
Recombinant human Dual specificity protein phosphatase 16 protein (C-250AA)
Conjugate
Non-conjugated
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Santa Cruz Alternative
Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-47903 / sc-47907 / sc-47904 / sc-98872
Preparation and Storage
Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Other Notes
Small volumes of anti-DUSP16 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-DUSP16 antibody
Dual specificity protein phosphatase involved in the inactivation of MAP kinases. Dephosphorylates MAPK10 bound to ARRB2.
Applications Tested/Suitable for anti-DUSP16 antibody
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)

Western Blot (WB) of anti-DUSP16 antibody
Western blot
All lanes: DUSP16 antibody IgG at 1.69ug/ml+ 293T whole cell lysate
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 74,17 kDa
Observed band size: 73 kDa

anti-DUSP16 antibody Western Blot (WB) (WB) image
Immunohistochemistry (IHC) of anti-DUSP16 antibody
Immunohistochemistry of paraffin-embedded human lung tissue using MBS7045838 at dilution 1:100
anti-DUSP16 antibody Immunohistochemistry (IHC) (IHC) image
Immunohistochemistry (IHC) of anti-DUSP16 antibody
Immunohistochemistry of paraffin-embedded human colon cancer using MBS7045838 at dilution 1:100
anti-DUSP16 antibody Immunohistochemistry (IHC) (IHC) image
NCBI/Uniprot data below describe general gene information for DUSP16. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
16,078 Da
NCBI Official Full Name
dual specificity protein phosphatase 16
NCBI Official Synonym Full Names
dual specificity phosphatase 16
NCBI Official Symbol
DUSP16  [Similar Products]
NCBI Official Synonym Symbols
MKP7; MKP-7
  [Similar Products]
NCBI Protein Information
dual specificity protein phosphatase 16
UniProt Protein Name
Dual specificity protein phosphatase 16
UniProt Synonym Protein Names
Mitogen-activated protein kinase phosphatase 7; MAP kinase phosphatase 7; MKP-7
UniProt Gene Name
DUSP16  [Similar Products]
UniProt Synonym Gene Names
KIAA1700; MKP7; MAP kinase phosphatase 7; MKP-7  [Similar Products]
UniProt Entry Name
DUS16_HUMAN
NCBI Summary for DUSP16
This gene encodes a mitogen-activated protein kinase phosphatase that is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. The encoded protein specifically regulates the c-Jun amino-terminal kinase (JNK) and extracellular signal-regulated kinase (ERK) pathways.[provided by RefSeq, May 2010]
UniProt Comments for DUSP16
MKP-7: a non-receptor, dual-specificity phosphoprotein phosphatase (DUSP). Different members of the DUSP family show distinct substrate specificities for MAPKs, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. DUSP16 suppresses MAPK activation in the order of selectivity, JNK >> p38 > ERK, but interacts with ERK as well as JNK and p38. Overexpression of DUSP16 in BCR-ABL-transformed fibroblasts reduces their transforming capacity in vitro and in vivo via down regulation of BCR-ABL-induced JNK activation. DUSP16 might be haploinsufficient for tumor suppression. Contains 1 rhodanese domain.

Protein type: EC 3.1.3.48; EC 3.1.3.16; Protein phosphatase, dual-specificity

Chromosomal Location of Human Ortholog: 12p13

Cellular Component: cytoplasm; nucleoplasm; nucleus

Molecular Function: phosphoprotein phosphatase activity

Biological Process: dephosphorylation; inactivation of MAPK activity; MAPK export from nucleus; MAPK phosphatase export from nucleus, leptomycin B sensitive
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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