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anti-FXYD5 antibody :: Rabbit anti-Human Dysadherin Polyclonal Antibody

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Catalog # MBS175496
Unit / Price
  0.1 mg  /  $315 +1 FREE 8GB USB
Product Name

Dysadherin (FXYD5), Polyclonal Antibody

Popular Item
Full Product Name

Anti-Dysadherin antibody

Product Synonym Names
FXYD domain-containing ion transport regulator 5; FXYD domain containing ion transport regulator 5; Dysad antibody; Dysadherin antibody; FXYD 5 antibody; FXYD domain containing ion transport regulator 5 antibody; FXYD domain-containing ion transport regulator 5 antibody; Fxyd5 antibody; FXYD5_HUMAN antibody; FXYD5RIC antibody; HSPC 113 antibody; HSPC113 antibody; IWU 1 antibody; IWU1 antibody; KCT 1 antibody; KCT1 antibody; Keratinocytes associated transmembrane protein 1 antibody; OIT 2 antibody; OIT2 antibody; PRO 6241 antibody; PRO6241 antibody; RIC antibody
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
OMIM
606669
3D Structure
ModBase 3D Structure for Q96DB9
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Purity/Purification
Immunogen affinity purified.
Form/Format
Lyophilized
Immunogen
A synthetic peptide corresponding to a sequence at the C-terminus of human Dysadherin (165-188aa KCRQLSRLCRNRCR).
Contents
Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.
Reconstitution
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Preparation and Storage
At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time. Avoid repeated freezing and thawing.
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Other Notes
Small volumes of anti-FXYD5 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-FXYD5 antibody
Description: Rabbit IgG polyclonal antibody for FXYD domain-containing ion transport regulator 5(FXYD5) detection. Tested with WB, IHC-P in Human.
Background: FXYD5(FXYD domain-containing ion transport regulator 5), also known as Dysadherin, is a protein that in humans is encoded by the FXYD5 gene. The gene encodes a member of a family of small membrane proteins that share a 35-amino acid signature sequence domain, beginning with the sequence PFXYD and containing 7 invariant and 6 highly conserved amino acids. The FXYD5 gene is mapped on 19q13.12. The deduced FXYD5 protein, the largest of the 7, contains 178 amino acids and has a signal peptide. Immunoreactivity for dysadherin, localized at cell-cell boundaries, was detected in 39 of 51 papillary carcinomas and in all 31 undifferentiated carcinomas but not in the follicular carcinomas or normal thyroid tissue controls. Dysadherin expression was significantly higher in undifferentiated carcinoma than in papillary carcinoma or follicular carcinoma and showed significant negative correlation with E-cadherin expression.
Applications Tested/Suitable for anti-FXYD5 antibody
Western Blot (WB), Immunohistochemistry (IHC) Paraffin

Western Blot (WB) of anti-FXYD5 antibody
Anti- FXYD5 antibody, MBS175496, Western blotting
All lanes: Anti FXYD5 (MBS175496) at 0.5ug/ml
WB: Rat PancreasTissue Lysate at 50ug
Predicted bind size: 19KD
Observed bind size: 19KD
anti-FXYD5 antibody Western Blot (WB) (WB) image
Immunohistochemistry (IHC) of anti-FXYD5 antibody
Anti- FXYD5 antibody, MBS175496, IHC(P)
IHC(P): Human Mammary Cancer Tissue
anti-FXYD5 antibody Immunohistochemistry (IHC) (IHC) image
NCBI/Uniprot data below describe general gene information for FXYD5. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
11,888 Da
NCBI Official Full Name
FXYD domain-containing ion transport regulator 5
NCBI Official Synonym Full Names
FXYD domain containing ion transport regulator 5
NCBI Official Symbol
FXYD5  [Similar Products]
NCBI Official Synonym Symbols
RIC; IWU1; KCT1; OIT2; DYSAD; HSPC113; PRO6241
  [Similar Products]
NCBI Protein Information
FXYD domain-containing ion transport regulator 5; dysadherin; keratinocytes associated transmembrane protein 1
UniProt Protein Name
FXYD domain-containing ion transport regulator 5
UniProt Synonym Protein Names
Dysadherin
UniProt Gene Name
FXYD5  [Similar Products]
UniProt Synonym Gene Names
DYSAD; IWU1  [Similar Products]
UniProt Entry Name
FXYD5_HUMAN
NCBI Summary for FXYD5
This gene encodes a member of a family of small membrane proteins that share a 35-amino acid signature sequence domain, beginning with the sequence PFXYD and containing 7 invariant and 6 highly conserved amino acids. The approved human gene nomenclature for the family is FXYD-domain containing ion transport regulator. Mouse FXYD5 has been termed RIC (Related to Ion Channel). FXYD2, also known as the gamma subunit of the Na,K-ATPase, regulates the properties of that enzyme. FXYD1 (phospholemman), FXYD2 (gamma), FXYD3 (MAT-8), FXYD4 (CHIF), and FXYD5 (RIC) have been shown to induce channel activity in experimental expression systems. Transmembrane topology has been established for two family members (FXYD1 and FXYD2), with the N-terminus extracellular and the C-terminus on the cytoplasmic side of the membrane. This gene product, FXYD5, is a glycoprotein that functions in the up-regulation of chemokine production, and it is involved in the reduction of cell adhesion via its ability to down-regulate E-cadherin. It also promotes metastasis, and has been linked to a variety of cancers. Alternative splicing results in multiple transcript variants. [RefSeq curation by Kathleen J. Sweadner, Ph.D., sweadner@helix.mgh.harvard.edu., Sep 2009]
UniProt Comments for FXYD5
FXYD5: Involved in down-regulation of E-cadherin which results in reduced cell adhesion. Promotes metastasis. Belongs to the FXYD family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Cell adhesion; Actin-binding; Membrane protein, integral

Chromosomal Location of Human Ortholog: 19q13.12

Cellular Component: integral to membrane

Molecular Function: cadherin binding; ion channel activity; actin binding

Biological Process: negative regulation of calcium-dependent cell-cell adhesion; microvillus biogenesis
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

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