NP_001160167.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
Observed: 59 kDa Predicted: 60 kDa
NCBI Official Full Name
excitatory amino acid transporter 1 isoform 2
NCBI Official Synonym Full Names
solute carrier family 1 member 3
NCBI Protein Information
excitatory amino acid transporter 1
UniProt Protein Name
Excitatory amino acid transporter 1
UniProt Synonym Protein Names
Sodium-dependent glutamate/aspartate transporter 11 PublicationManual assertion based on opinion iniRef.4"Human high affinity, Na(+)-dependent L-glutamate/L-aspartate transporter GLAST-1 (EAAT-1): gene structure and localization to chromosome 5p11-p12."Stoffel W., Sasse J., Dueker M., Mueller R., Hofmann K.O., Fink T., Lichter P.FEBS Lett. 386:189-193(1996) [PubMed] [Europe PMC] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
UniProt Synonym Gene Names
EAAT12 PublicationsManual assertion based on opinion iniRef.4; GLAST-11 PublicationManual assertion based on opinion iniRef.4 [Similar Products]
NCBI Summary for EAAT1
This gene encodes a member of a member of a high affinity glutamate transporter family. This gene functions in the termination of excitatory neurotransmission in central nervous system. Mutations are associated with episodic ataxia, Type 6. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Feb 2014]
UniProt Comments for EAAT1
Sodium-dependent, high-affinity amino acid transporter that mediates the uptake of L-glutamate and also L-aspartate and D-aspartate (PubMed:7521911, PubMed:8123008, PubMed:20477940, PubMed:26690923, PubMed:28032905, PubMed:28424515). Functions as a symporter that transports one amino acid molecule together with two or three Na+ ions and one proton, in parallel with the counter-transport of one K+ ion (PubMed:20477940). Mediates Cl- flux that is not coupled to amino acid transport; this avoids the accumulation of negative charges due to aspartate and Na+ symport (PubMed:20477940). Plays a redundant role in the rapid removal of released glutamate from the synaptic cleft, which is essential for terminating the postsynaptic action of glutamate ().
Research Articles on EAAT1
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Products associated with anti-EAAT1 antibody
Pathways associated with anti-EAAT1 antibody
Diseases associated with anti-EAAT1 antibody
Organs/Tissues associated with anti-EAAT1 antibody
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