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anti-EHD1 antibody :: Rabbit anti-Human EHD1 Polyclonal Antibody

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Catalog # MBS7045128
Unit / Price
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  0.05 mg  /  $160 +1 FREE 8GB USB
  0.1 mg  /  $235 +1 FREE 8GB USB
Product Name

EHD1, Polyclonal Antibody

Popular Item
Full Product Name

EHD1 Antibody

Product Synonym Names
EH domain-containing protein 1Curated; PAST homolog 11; EHD1
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
OMIM
605888
3D Structure
ModBase 3D Structure for Q9H4M9
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Purity/Purification
>95%, Protein G purified
Form/Format
Liquid
Species
Human
Immunogen
Recombinant human EH domain-containing protein 1 protein
Conjugate
Non-conjugated
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Santa Cruz Alternative
Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-23450 / sc-23452 / sc-32917
Preparation and Storage
Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Other Notes
Small volumes of anti-EHD1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-EHD1 antibody
ATP- and membrane-binding protein that controls membrane reorganization/tubulation upon ATP hydrolysis. In vitro causes vesiculation of endocytic membranes (PubMed:24019528). Acts in early endocytic membrane fusion and membrane trafficking of recycling endosomes (PubMed:15020713, PubMed:17233914, PubMed:20801876). Recruited to endosomal membranes upon nerve growth factor stimulation, indirectly regulates neurite outgrowth (By similarity). Plays a role in myoblast fusion (By similarity). Involved in the unidirectional retrograde dendritic transport of endocytosed BACE1 and in efficient sorting of BACE1 to axons implicating a function in neuronal APP processing (By similarity). Plays a role in the formation of the ciliary vesicle (CV), an early step in cilium biogenesis. Proposed to be required for the fusion of distal appendage vesicles (DAVs) to form the CV by recruiting SNARE complex component SNAP29. Is required for recruitment of transition zone proteins CEP290, RPGRIP1L, TMEM67 and B9D2, and of IFT20 following DAV reorganization before Rab8-dependent ciliary membrane extension. Required for the loss of CCP110 form the mother centriole essential for the maturation of the basal body during ciliogenesis (PubMed:25686250).
Applications Tested/Suitable for anti-EHD1 antibody
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)

Western Blot (WB) of anti-EHD1 antibody
Western blot
All lanes: EHD1 antibody at 12 ug/ml+ MDA-MB-231 whole cell lysate
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 61 kDa
Observed band size: 61 kDa

anti-EHD1 antibody Western Blot (WB) (WB) image
Immunohistochemistry (IHC) of anti-EHD1 antibody
Immunohistochemistry of paraffin-embedded human tonsil tissue using MBS7045128 at dilution of 1:100
anti-EHD1 antibody Immunohistochemistry (IHC) (IHC) image
NCBI/Uniprot data below describe general gene information for EHD1. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
60,627 Da
NCBI Official Full Name
EH domain-containing protein 1 isoform 1
NCBI Official Synonym Full Names
EH domain containing 1
NCBI Official Symbol
NCBI Official Synonym Symbols
PAST; PAST1; H-PAST; HPAST1
  [Similar Products]
NCBI Protein Information
EH domain-containing protein 1
UniProt Protein Name
EH domain-containing protein 1
UniProt Synonym Protein Names
PAST homolog 1
UniProt Gene Name
UniProt Synonym Gene Names
hPAST1  [Similar Products]
UniProt Entry Name
EHD1_HUMAN
NCBI Summary for EHD1
This gene belongs to a highly conserved gene family encoding EPS15 homology (EH) domain-containing proteins. The protein-binding EH domain was first noted in EPS15, a substrate for the epidermal growth factor receptor. The EH domain has been shown to be an important motif in proteins involved in protein-protein interactions and in intracellular sorting. The protein encoded by this gene is thought to play a role in the endocytosis of IGF1 receptors. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2013]
UniProt Comments for EHD1
EHD1: Acts in early endocytic membrane fusion and membrane trafficking of recycling endosomes.

Protein type: Calcium-binding; Vesicle

Chromosomal Location of Human Ortholog: 11q13

Cellular Component: early endosome membrane; endosome membrane; lipid particle; membrane; plasma membrane; recycling endosome membrane

Molecular Function: protein binding; Rab GTPase binding

Biological Process: blood coagulation; cholesterol homeostasis; cilium biogenesis; endocytic recycling; endocytosis; intracellular protein transport; neurite development; protein homooligomerization
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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