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anti-ERVW-1 antibody :: Rabbit anti-Human ERVW-1 Polyclonal Antibody

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Catalog # MBS7051530
Unit / Price
  0.05 mg  /  $160 +1 FREE 8GB USB
  0.1 mg  /  $235 +1 FREE 8GB USB
Product Name

ERVW-1, Polyclonal Antibody

Popular Item
Also Known As

ERVW-1 Antibody

Product Synonym Names
Syncytin-1; Endogenous retrovirus group W member 1; Env-W; Envelope polyprotein gPr73; Enverin; HERV-7q Envelope protein; HERV-W envelope protein; HERV-W_7q21.2 provirus ancestral Env polyprotein; Syncytin; Surface protein; SU; gp50; Transmembrane protein; TM; gp24; ERVW-1; ERVWE1
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Length
538
OMIM
AF072503 mRNA
3D Structure
ModBase 3D Structure for Q9UQF0
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Purity/Purification
>95%, Protein G purified
Form/Format
Liquid
Immunogen
Recombinant Human Syncytin-1 protein (21-443AA)
Preservative
0.03% Proclin 300
Constituents
50% Glycerol, 0.01M PBS, pH 7.4
Conjugation
Non-conjugated
Santa Cruz Alternative
Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-130888 / sc-30640 / sc-50369
Preparation and Storage
Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Other Notes
Small volumes of anti-ERVW-1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-ERVW-1 antibody
This endogenous retroviral envelope protein has retained its original fusogenic properties and participates in trophoblast fusion and the formation of a syncytium during placenta morphogenesis. May induce fusion through binding of SLC1A4 and SLC1A5 (PubMed: 10708449, PubMed: 12050356, PubMed: 23492904).
Applications Tested/Suitable for anti-ERVW-1 antibody
ELISA (EIA), Immunohistochemistry (IHC), Immunofluorescence (IF)
Application Notes for anti-ERVW-1 antibody
IHC: 1: 20-1: 200
IF: 1: 50-1: 200

Immunohistochemistry (IHC) of anti-ERVW-1 antibody
Immunohistochemistry of paraffin-embedded human placenta tissue using MBS7051530 at dilution of 1:100
anti-ERVW-1 antibody Immunohistochemistry (IHC) (IHC) image
Immunofluorescence (IF) of anti-ERVW-1 antibody
Immunofluorescent analysis of HepG2 cells using MBS7051530 at a dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
anti-ERVW-1 antibody Immunofluorescence (IF) image
NCBI/Uniprot data below describe general gene information for ERVW-1. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
59,866 Da
NCBI Official Full Name
syncytin-1
NCBI Official Synonym Full Names
endogenous retrovirus group W member 1
NCBI Official Symbol
ERVW-1  [Similar Products]
NCBI Official Synonym Symbols
ENV; ENVW; HERVW; ERVWE1; HERV7Q; HERV-7q; HERVWENV; HERV-W-ENV
  [Similar Products]
NCBI Protein Information
syncytin-1
UniProt Protein Name
Syncytin-1
UniProt Synonym Protein Names
Endogenous retrovirus group W member 1; Env-W; Envelope polyprotein gPr73; Enverin; HERV-7q Envelope protein; HERV-W envelope protein; HERV-W_7q21.2 provirus ancestral Env polyprotein; Syncytin
Protein Family
UniProt Gene Name
ERVW-1  [Similar Products]
UniProt Synonym Gene Names
ERVWE1; SU; TM  [Similar Products]
UniProt Entry Name
SYCY1_HUMAN
NCBI Summary for ERVW-1
Many different human endogenous retrovirus (HERV) families are expressed in normal placental tissue at high levels, suggesting that HERVs are functionally important in reproduction. This gene is part of an HERV provirus on chromosome 7 that has inactivating mutations in the gag and pol genes. This gene is the envelope glycoprotein gene which appears to have been selectively preserved. The gene's protein product is expressed in the placental syncytiotrophoblast and is involved in fusion of the cytotrophoblast cells to form the syncytial layer of the placenta. The protein has the characteristics of a typical retroviral envelope protein, including a furin cleavage site that separates the surface (SU) and transmembrane (TM) proteins which form a heterodimer. Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Mar 2010]
UniProt Comments for ERVW-1
ERVWE1: Retroviral envelope proteins mediate receptor recognition and membrane fusion during early infection. Endogenous envelope proteins may have kept, lost or modified their original function during evolution. This endogenous envelope protein has retained its original fusogenic properties and participates in trophoblast fusion during placenta morphogenesis. Belongs to the gamma type-C retroviral envelope protein family. HERV class-I W env subfamily.

Protein type: Cell surface; Membrane protein, integral

Chromosomal Location of Human Ortholog: 7q21.2

Biological Process: anatomical structure morphogenesis; syncytium formation
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Products associated withanti-ERVW-1 antibody
 Reference Product  PubMed Publications
 GCM1 antibody  >1 publications with ERVW-1 and GCM1
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