• Call +1.858.633.0165 or Fax +1.858.633.0166 or Contact Us

anti-ESR2 antibody :: Goat Estrogen receptor beta Polyclonal Antibody

Scan QR to view Datasheet
Catalog # MBS422960
Unit / Price
Scan QR to view Datasheet
  0.1 mg  /  $300 +1 FREE 8GB USB
Western Blot (WB)
Product Name

Estrogen receptor beta (ESR2), Polyclonal Antibody

Full Product Name

Goat anti-Estrogen receptor beta (aa417-428) Antibody

Product Synonym Names
Goat Anti-Estrogen receptor 2 Antibody; ESR2; estrogen receptor 2 (ER beta); ER-BETA; ESR-BETA; ESRB; ESTRB; Erb; NR3A2; OTTHUMP00000180647; estrogen nuclear receptor beta variant a; estrogen nuclear receptor beta variant b; estrogen receptor beta; estrogen receptor beta 4; nuclear receptor sub; Erb antibody; ER-BETA antibody; ESR2 antibody; ESRB antibody; ESR-BETA antibody; ESTRB antibody; estrogen nuclear receptor beta variant a antibody; estrogen nuclear receptor beta variant b antibody; estrogen receptor 2 (ER beta) antibody; estrogen receptor beta antibody; estrogen receptor beta 4 antibody; NR3A2 antibody; nuclear receptor subfamily 3 group A member 2 antibody; OTTHUMP00000180647 antibody; Estrogen receptor beta; Estrogen receptor beta (aa417-428)
Antibody/Peptide Pairs
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence
TQDADSSRKL AH
OMIM
601663
Clonality
Polyclonal
Host
Goat
Species Reactivity
Tested: Human; Expected from sequence similarity: Human
Purity/Purification
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Form/Format
Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
Concentration
100ug specific antibody in 200ul (lot specific)
Immunogen
Peptide with sequence C-TQDADSSRKLAH, from the internal region of the protein sequence according to NP_001428.1; NP_001035365.1; NP_001201831.1; NP_001201832.1.
Epitope
Internal region
Note
This antibody is expected to recognize all reported isoforms (NP_001428.1; NP_001035365.1; NP_001201831.1; NP_001201832.1). Reported variants represent identical protein: NP_001035365.1, NP_001035366.1
Preparation and Storage
Aliquot and store at -20 degree C. Minimize freezing and thawing.
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Other Notes
Small volumes of anti-ESR2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-ESR2 antibody
Peptide ELISA (EIA), Western Blot (WB)
Application Notes for anti-ESR2 antibody
Peptide ELISA: Antibody detection limit dilution 1: 128000.
Western Blot: Approx 50kDa band observed in Human Placenta lysates (calculated MW of 53. 0kDa according to NP_001035366.1). Recommended concentration: 1-3ug/ml.

Western Blot (WB) of anti-ESR2 antibody
(1ug/ml) staining of Human Placenta lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
anti-ESR2 antibody Western Blot (WB) (WB) image
NCBI/Uniprot data below describe general gene information for ESR2. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI Related Accession #
Manufactured in an ISO 9001:2015 Certified Laboratory.NP_001035365.1; NP_001201831.1; NP_001201832.1[Other Products]
NCBI GenBank Nucleotide #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
53,209 Da
NCBI Official Full Name
estrogen receptor beta isoform 1
NCBI Official Synonym Full Names
estrogen receptor 2
NCBI Official Symbol
NCBI Official Synonym Symbols
Erb; ESRB; ESTRB; NR3A2; ER-BETA; ESR-BETA
  [Similar Products]
NCBI Protein Information
estrogen receptor beta
UniProt Protein Name
Estrogen receptor beta
UniProt Synonym Protein Names
Nuclear receptor subfamily 3 group A member 2
Protein Family
UniProt Gene Name
UniProt Synonym Gene Names
ESTRB; NR3A2; ER-beta  [Similar Products]
UniProt Entry Name
ESR2_HUMAN
NCBI Summary for ESR2
This gene encodes a member of the family of estrogen receptors and superfamily of nuclear receptor transcription factors. The gene product contains an N-terminal DNA binding domain and C-terminal ligand binding domain and is localized to the nucleus, cytoplasm, and mitochondria. Upon binding to 17beta-estradiol or related ligands, the encoded protein forms homo- or hetero-dimers that interact with specific DNA sequences to activate transcription. Some isoforms dominantly inhibit the activity of other estrogen receptor family members. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been fully characterized. [provided by RefSeq, Jul 2008]
UniProt Comments for ESR2
ER-beta: a nuclear hormone receptor and transcription factor. Binds and activated by estrogen. Regulates gene expression and affects cellular proliferation and differentiation in target tissues. Binds estrogens with an affinity similar to that of ER-alpha, and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner. Eight alternatively-spliced isoforms have been described. Isoform beta-cx lacks ligand binding ability and has no or only very low ERE binding activity resulting in the loss of ligand-dependent transactivation ability.

Protein type: Nuclear receptor; DNA-binding

Chromosomal Location of Human Ortholog: 14q23.2

Cellular Component: cilium; extracellular region; mitochondrion; neuron projection; nucleoplasm; nucleus; perikaryon; perinuclear region of cytoplasm; plasma membrane

Molecular Function: DNA binding; drug binding; enzyme binding; estrogen receptor activity; estrogen response element binding; ligand-dependent nuclear receptor activity; peroxisome proliferator activated receptor binding; protein binding; receptor antagonist activity; steroid binding; steroid hormone receptor activity; transcription coactivator activity; transcription factor activity; zinc ion binding

Biological Process: amygdala development; behavioral fear response; cell-cell signaling; cerebellum development; estrogen receptor signaling pathway; hypothalamus development; learning and/or memory; negative regulation of cell growth; negative regulation of epithelial cell proliferation; negative regulation of smooth muscle cell proliferation; negative regulation of transcription from RNA polymerase II promoter; ovarian follicle development; positive regulation of apoptosis; positive regulation of epidermal growth factor receptor signaling pathway; positive regulation of transcription factor activity; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; positive regulation of vasodilation; prostate gland development; regulation of neuron apoptosis; regulation of transcription, DNA-dependent; response to activity; response to ethanol; response to genistein; response to insecticide; response to nutrient levels; response to testosterone stimulus; response to water deprivation; Sertoli cell development; Sertoli cell proliferation; signal transduction; transcription initiation from RNA polymerase II promoter
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Organs/Tissues associated with anti-ESR2 antibody
Request a Quote

Please fill out the form below and our representative will get back to you shortly.

MBS000000
Contact Us

Please fill out the form below and our representative will get back to you shortly.

MBS000000