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anti-ETFA antibody :: Rabbit anti-Human ETFA Polyclonal Antibody

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Catalog # MBS7046024
Unit / Price
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  0.05 mL  /  $120 +1 FREE 8GB USB
  0.1 mL  /  $160 +1 FREE 8GB USB
Product Name

ETFA, Polyclonal Antibody

Popular Item
Full Product Name

ETFA Antibody

Product Synonym Names
Electron transfer flavoprotein subunit alpha, mitochondrial; Alpha-ETF; ETFA
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
OMIM
231680
3D Structure
ModBase 3D Structure for P13804
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Purity/Purification
Antigen Affinity Purified
Form/Format
Liquid
Species
Human
Immunogen
Recombinant human Electron transfer flavoprotein subunit alpha, mitochondrial protein (1-333AA)
Conjugate
Non-conjugated
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Santa Cruz Alternative
Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-66220 / sc-66219
Preparation and Storage
Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of anti-ETFA antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-ETFA antibody
The electron transfer flavoprotein serves as a specific electron acceptor for several dehydrogenases, including five acyl-CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase. It transfers the electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase).
Applications Tested/Suitable for anti-ETFA antibody
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)

Western Blot (WB) of anti-ETFA antibody
Western blot
All lanes:  ETFA antibody at 4.34 ug/ml
Lane 1 : A431 whole cell lysate
Lane 2 : Hela whole cell lysate
Lane 3 : K562 whole cell lysate
Lane 4 : A549 whole cell lysate
Lane 5 : HepG-2 whole cell lysate
Lane 6 : MCF7 whole cell lysate
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 36,31 kDa
Observed band size: 35 kDa

anti-ETFA antibody Western Blot (WB) (WB) image
Immunohistochemistry (IHC) of anti-ETFA antibody
Immunohistochemistry of paraffin-embedded human colon cancer using MBS7046024 at dilution 1:100
anti-ETFA antibody Immunohistochemistry (IHC) (IHC) image
Immunohistochemistry (IHC) of anti-ETFA antibody
Immunohistochemistry of paraffin-embedded human kidney tissue using MBS7046024 at dilution 1:100
anti-ETFA antibody Immunohistochemistry (IHC) (IHC) image
NCBI/Uniprot data below describe general gene information for ETFA. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
30,026 Da
NCBI Official Full Name
electron transfer flavoprotein subunit alpha, mitochondrial isoform a
NCBI Official Synonym Full Names
electron transfer flavoprotein alpha subunit
NCBI Official Symbol
NCBI Official Synonym Symbols
EMA; GA2; MADD
  [Similar Products]
NCBI Protein Information
electron transfer flavoprotein subunit alpha, mitochondrial
UniProt Protein Name
Electron transfer flavoprotein subunit alpha, mitochondrial
UniProt Gene Name
UniProt Synonym Gene Names
Alpha-ETF  [Similar Products]
UniProt Entry Name
ETFA_HUMAN
NCBI Summary for ETFA
ETFA participates in catalyzing the initial step of the mitochondrial fatty acid beta-oxidation. It shuttles electrons between primary flavoprotein dehydrogenases and the membrane-bound electron transfer flavoprotein ubiquinone oxidoreductase. Defects in electron-transfer-flavoprotein have been implicated in type II glutaricaciduria in which multiple acyl-CoA dehydrogenase deficiencies result in large excretion of glutaric, lactic, ethylmalonic, butyric, isobutyric, 2-methyl-butyric, and isovaleric acids. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
UniProt Comments for ETFA
ETFA: The electron transfer flavoprotein serves as a specific electron acceptor for several dehydrogenases, including five acyl- CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase. It transfers the electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase). Defects in ETFA are the cause of glutaric aciduria type 2A (GA2A); also known as glutaricaciduria IIA. GA2A is an autosomal recessively inherited disorder of fatty acid, amino acid, and choline metabolism. It is characterized by multiple acyl-CoA dehydrogenase deficiencies resulting in large excretion not only of glutaric acid, but also of lactic, ethylmalonic, butyric, isobutyric, 2-methyl-butyric, and isovaleric acids. Belongs to the ETF alpha-subunit/FixB family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Mitochondrial; Oxidoreductase

Chromosomal Location of Human Ortholog: 15q23-q25

Cellular Component: mitochondrial matrix; mitochondrion

Molecular Function: acyl-CoA binding; acyl-CoA dehydrogenase activity; electron carrier activity; FAD binding; oxidoreductase activity

Biological Process: fatty acid beta-oxidation using acyl-CoA dehydrogenase; lipid homeostasis

Disease: Multiple Acyl-coa Dehydrogenase Deficiency
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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