NP_001129122.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
15,548 Da
NCBI Official Full Name
eukaryotic translation elongation factor 1 epsilon-1 isoform 2
NCBI Official Synonym Full Names
eukaryotic translation elongation factor 1 epsilon 1
NCBI Official Synonym Symbols
NCBI Protein Information
eukaryotic translation elongation factor 1 epsilon-1
UniProt Protein Name
Eukaryotic translation elongation factor 1 epsilon-1
UniProt Synonym Protein Names
Aminoacyl tRNA synthetase complex-interacting multifunctional protein 3; Elongation factor p18; Multisynthase complex auxiliary component p18
UniProt Synonym Gene Names
UniProt Entry Name
MCA3_HUMAN
NCBI Summary for EEF1E1
This gene encodes a multifunctional protein that localizes to both the cytoplasm and nucleus. In the cytoplasm, the encoded protein is an auxiliary component of the macromolecular aminoacyl-tRNA synthase complex. However, its mouse homolog has been shown to translocate to the nucleus in response to DNA damage, and it plays a positive role in ATM/ATR-mediated p53 activation. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the neighboring downstream MUTED (muted homolog) gene. An EEF1E1-related pseudogene has been identified on chromosome 2. [provided by RefSeq, Dec 2010]
UniProt Comments for EEF1E1
EEF1E1: Positive modulator of ATM response to DNA damage.
Protein type: Translation; Translation elongation
Chromosomal Location of Human Ortholog: 6p24.3
Cellular Component: cytoplasm; cytosol; nucleus
Molecular Function: glutathione transferase activity; protein binding; translation elongation factor activity
Biological Process: gene expression; glutathione metabolic process; negative regulation of cell proliferation; positive regulation of apoptosis; positive regulation of DNA damage response, signal transduction by p53 class mediator; selenium metabolic process; translational elongation; tRNA aminoacylation for protein translation
Research Articles on EEF1E1
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Products associated with anti-EEF1E1 antibody
Pathways associated with anti-EEF1E1 antibody
Diseases associated with anti-EEF1E1 antibody
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