NP_001135936.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
33,938 Da
NCBI Official Full Name
evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial isoform 2
NCBI Official Synonym Full Names
ECSIT signalling integrator
NCBI Official Synonym Symbols
NCBI Protein Information
evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial
UniProt Protein Name
Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial
UniProt Synonym Protein Names
Protein SITPEC
UniProt Entry Name
ECSIT_HUMAN
UniProt Comments for ECSIT
ECSIT: Adapter protein of the Toll-like and IL-1 receptor signaling pathway that is involved in the activation of NF-kappa-B via MAP3K1. Promotes proteolytic activation of MAP3K1. Involved in the BMP signaling pathway. Required for normal embryonic development. Required for efficient assembly of mitochondrial NADH:ubiquinone oxidoreductase. Belongs to the ECSIT family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Adaptor/scaffold; Transcription factor
Chromosomal Location of Human Ortholog: 19p13.2
Cellular Component: cytoplasm; mitochondrial inner membrane; mitochondrion; nucleoplasm; nucleus
Molecular Function: oxidoreductase activity, acting on NADH or NADPH; protein binding
Biological Process: cellular metabolic process; innate immune response; mitochondrial respiratory chain complex I assembly; regulation of oxidoreductase activity
Research Articles on ECSIT
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Products associated with anti-ECSIT antibody
Pathways associated with anti-ECSIT antibody
Diseases associated with anti-ECSIT antibody
Organs/Tissues associated with anti-ECSIT antibody
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