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anti-EXOSC5 antibody :: Rabbit anti-Human EXOSC5 Polyclonal Antibody

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Catalog # MBS7002295
Unit / Price
  0.05 mg  /  $160 +1 FREE 8GB USB
  0.1 mg  /  $235 +1 FREE 8GB USB
Product Name

EXOSC5, Polyclonal Antibody

Popular Item
Also Known As

EXOSC5 Antibody

Product Synonym Names
Exosome complex component RRP46; EXOSC5; CML28; RRP46; Chronic myelogenous leukemia tumor antigen 28; Exosome component 5; Ribosomal RNA-processing protein 46; p12B
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Length
235
OMIM
606492
3D Structure
ModBase 3D Structure for Q9NQT4
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Purity/Purification
Affinity Purified
Form/Format
Liquid
Immunogen
Recombinant human Exosome complex component RRP46 protein
Conjugation
Non-conjugated
Storage Buffer
Preservative: 0.03% Proclin 300; Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Santa Cruz Alternative
Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-131154
Preparation and Storage
Shipped at 4 degree C. Upon delivery, aliquot and store at -20 degree C or -80 degree C.
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Other Notes
Small volumes of anti-EXOSC5 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-EXOSC5 antibody
Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes.
Applications Tested/Suitable for anti-EXOSC5 antibody
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-EXOSC5 antibody
Recommended dilution: WB:1:500-2000, IHC:1:20-1:200

Western Blot (WB) of anti-EXOSC5 antibody
Western blot
All lanes: EXOSC5 antibody at 5ug/ml
Lane 1:K562 whole cell lysate
Lane 2:293T whole cell lysate
Lane 3:Hela whole cell lysate
Secondary
Goat polyclonal to rabbit at 1/10000 dilution
Predicted band size: 25kDa
Observed band size: 25kDa

anti-EXOSC5 antibody Western Blot (WB) (WB) image
Immunohistochemistry (IHC) of anti-EXOSC5 antibody
Immunohistochemistry of paraffin-embedded human testis tissue using MBS7002295 at dilution 1:100
anti-EXOSC5 antibody Immunohistochemistry (IHC) (IHC) image
Immunohistochemistry (IHC) of anti-EXOSC5 antibody
Immunohistochemistry of paraffin-embedded human breast cancer tissue using MBS7002295 at dilution 1:100
anti-EXOSC5 antibody Immunohistochemistry (IHC) (IHC) image
NCBI/Uniprot data below describe general gene information for EXOSC5. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
25,249 Da
NCBI Official Full Name
exosome complex component RRP46
NCBI Official Synonym Full Names
exosome component 5
NCBI Official Symbol
EXOSC5  [Similar Products]
NCBI Official Synonym Symbols
p12B; RRP46; RRP41B; Rrp46p; hRrp46p
  [Similar Products]
NCBI Protein Information
exosome complex component RRP46
UniProt Protein Name
Exosome complex component RRP46
UniProt Synonym Protein Names
Chronic myelogenous leukemia tumor antigen 28; Exosome component 5; Ribosomal RNA-processing protein 46; p12B
Protein Family
UniProt Gene Name
EXOSC5  [Similar Products]
UniProt Synonym Gene Names
CML28; RRP46  [Similar Products]
UniProt Entry Name
EXOS5_HUMAN
UniProt Comments for EXOSC5
EXOSC5: Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes. Belongs to the RNase PH family.

Protein type: EC 3.1.13.-; Nucleolus; Ribonuclease

Chromosomal Location of Human Ortholog: 19q13.1

Cellular Component: cytoplasm; cytosol; exosome (RNase complex); nuclear exosome (RNase complex); nucleolus; nucleus

Molecular Function: 3'-5'-exoribonuclease activity; exoribonuclease activity; protein binding; RNA binding

Biological Process: defense response to virus; DNA deamination; gene expression; mRNA catabolic process, deadenylation-dependent decay; regulation of mRNA stability; rRNA 3'-end processing; rRNA catabolic process; rRNA processing
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Products associated withanti-EXOSC5 antibody
 Reference Product  PubMed Publications
 EXOSC4 antibody  >1 publications with EXOSC5 and EXOSC4
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