View our list of available Coronavirus (COVID-19, SARS-CoV-2, 2019-nCOV) antibodies, recombinant proteins, ELISA Kits... Options Full Datasheet Printer Friendly Datasheet Prepare for Printing Full Datasheet Printer Friendly Datasheet Prepare for Printing Have Questions? Ask Us! Request A Quote Today! Add To Compare List Sheep anti-Human Factor VIIIc Polyclonal Antibody Catalog # MBS621342 Unit / Price 1 mg / $455 +1 FREE 8GB USB 10 mg / $800 +1 FREE 8GB USB 5x10 mg / $3,420 +4 FREE 8GB USB Product Name Product Info Accession #s Product Desc Diseases/Tissues/Pathways Applications References Product Name Factor VIIIc, Polyclonal Antibody Popular Item Full Product Name Factor VIIIc (Antihaemophilic Factor) Product Synonym Names Anti -Factor VIIIc (Antihaemophilic Factor) Research Use Only For Research Use Only. Not for use in diagnostic procedures. TOP Clonality Polyclonal Isotype IgG Host Sheep Species Reactivity Human Specificity Recognizes human F.VIII as demonstrated by immunodiffusion and ELISA. No reactivity was observed with von Willebrand Factor. Purity/Purification PurifiedPurified by caprylic acid and ammonium sulfate precipitations, and solid -phase adsorption to remove unwanted crossreactivity. Form/Format Supplied as a liquid in 10mM HEPES, pH 7.4, 0.15M sodium chloride, 50% glycerol. Immunogen Human Factor VIIIC (F.VIII) purified from concentrate Preparation and Storage May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Other Notes Small volumes of anti-Factor VIIIc antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply. TOP Related Product Information for anti-Factor VIIIc antibody Factor VIII (antihemophilic globulin and Factor VIII:C) is a large glycoprotein (320kD) that circulates in plasma at ~200ng/ml. Synthesized in the liver, the majority of Factor VIII is cleaved during expression, resulting in a heterogeneous mixture of partially cleaved forms of F.VIII ranging in size from 200-280kD. The F.VIII is stabilized by association with von Willebrand Factor to form a F.VIII-vWF complex required for the normal survival of F.VIII in vivo (t1/2 of 8-12 hours). F.VIII is a pro-cofactor that is activated through limited proteolysis by thrombin. In this process F.VIIIa dissociates from vWF to combine with activated Factor IX, calcium and a phospholipid surface where it is an essential cofactor in the assembly of the Factor X activator complex. Once dissociated from vWF, F.VIIIa is susceptible to inactivation by activated Protein C and by non-enzymatic decay. Product Categories/Family for anti-Factor VIIIc antibody Antibodies; Abs to Coagulation Factors Applications Tested/Suitable for anti-Factor VIIIc antibody ELISA (EL/EIA), Neutralization Application Notes for anti-Factor VIIIc antibody Suitable for use in ELISA, Immunoelectrophoresis and Neutralization.Dilution: Neutralization: 1175 Bethesda Units/ml IgG against normal plasma (4). One Bethesda unit/ml is defined as the amount of inhibitor that resulted in 50% residual F.VIII activity after 2 hours at 37ºC. TOP NCBI/Uniprot data below describe general gene information for Factor VIIIc. It may not necessarily be applicable to this product. NCBI GI # 224258 TOP NCBI Official Full Name factor VIIIC TOP Precautions All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines. Disclaimer While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information. TOP Products associated with anti-Factor VIIIc antibody Reference Product PubMed Publications FLNA antibody >12 publications with Factor VIIIc and FLNA Pathways associated with anti-Factor VIIIc antibody Products by Pathway Pathway Diagram Focal Adhesion Pathway antibodies Focal Adhesion Pathway Diagram Focal Adhesion Pathway antibodies Focal Adhesion Pathway Diagram MAPK Signaling Pathway antibodies MAPK Signaling Pathway Diagram MAPK Signaling Pathway antibodies MAPK Signaling Pathway Diagram Salmonella Infection Pathway antibodies Salmonella Infection Pathway Diagram Salmonella Infection Pathway antibodies Salmonella Infection Pathway Diagram Organs/Tissues associated with anti-Factor VIIIc antibody Organ/Tissue Name Pubmed Publications Bone Antibodies >13 publications with Factor VIIIc and Bone Connective Tissue Antibodies >4 publications with Factor VIIIc and Connective Tissue Heart Antibodies >3 publications with Factor VIIIc and Heart Muscle Antibodies >3 publications with Factor VIIIc and Muscle Brain Antibodies >3 publications with Factor VIIIc and Brain Vascular Antibodies >2 publications with Factor VIIIc and Vascular Embryonic Tissue Antibodies >2 publications with Factor VIIIc and Embryonic Tissue Ear Antibodies >1 publications with Factor VIIIc and Ear Kidney Antibodies >1 publications with Factor VIIIc and Kidney Umbilical Cord Antibodies >1 publications with Factor VIIIc and Umbilical Cord TOP