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anti-F13B antibody :: Rabbit anti-Human Factor XIII B Polyclonal Antibody

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Catalog # MBS9406236
Unit / Price
  0.05 mL  /  $200 +1 FREE 8GB USB
  0.1 mL  /  $255 +1 FREE 8GB USB
Western Blot (WB)
Product Name

Factor XIII B (F13B), Polyclonal Antibody

Popular Item
Full Product Name

Factor XIII B Polyclonal Antibody

Product Synonym Names
F13B; Coagulation factor XIII B chain; Fibrin-stabilizing factor B subunit; Protein-glutamine gamma-glutamyltransferase B chain; Transglutaminase B chain
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
OMIM
134580
3D Structure
ModBase 3D Structure for P05160
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human
Specificity
Factor XIII B Polyclonal Antibody detects endogenous levels of Factor XIII B protein.
Purity/Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Form/Format
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration
1 mg/ml (lot specific)
Immunogen Type
peptide
Immunogen Description
Synthesized peptide derived from the N-terminal region of human Factor XIII B.
Target Name
Factor XIII B
Preparation and Storage
Store at -20 degree C/1 year
Other Notes
Small volumes of anti-F13B antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Product Categories/Family for anti-F13B antibody
Applications Tested/Suitable for anti-F13B antibody
Immunohistochemistry (IHC), Immunfluorescence (IF), ELISA (EIA), Western Blot (WB)
Application Notes for anti-F13B antibody
Western Blot||1:500-2000!!Immunohistochemistry: 1:100 - 1:300
Immunofluorescence: 1:200 - 1:1000
ELISA: 1:20000
Not yet tested in other applications.

Western Blot (WB) of anti-F13B antibody
Western Blot analysis of COLO cells using Factor XIII B Polyclonal Antibody
anti-F13B antibody Western Blot (WB) (WB) image
NCBI/Uniprot data below describe general gene information for F13B. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
NCBI Official Full Name
coagulation factor XIII B chain
NCBI Official Synonym Full Names
coagulation factor XIII, B polypeptide
NCBI Official Symbol
NCBI Official Synonym Symbols
FXIIIB
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NCBI Protein Information
coagulation factor XIII B chain
UniProt Protein Name
Coagulation factor XIII B chain
UniProt Synonym Protein Names
Fibrin-stabilizing factor B subunit; Protein-glutamine gamma-glutamyltransferase B chain; Transglutaminase B chain
Protein Family
UniProt Gene Name
UniProt Entry Name
F13B_HUMAN
NCBI Summary for F13B
This gene encodes coagulation factor XIII B subunit. Coagulation factor XIII is the last zymogen to become activated in the blood coagulation cascade. Plasma factor XIII is a heterotetramer composed of 2 A subunits and 2 B subunits. The A subunits have catalytic function, and the B subunits do not have enzymatic activity and may serve as a plasma carrier molecules. Platelet factor XIII is comprised only of 2 A subunits, which are identical to those of plasma origin. Upon activation by the cleavage of the activation peptide by thrombin and in the presence of calcium ion, the plasma factor XIII dissociates its B subunits and yields the same active enzyme, factor XIIIa, as platelet factor XIII. This enzyme acts as a transglutaminase to catalyze the formation of gamma-glutamyl-epsilon-lysine crosslinking between fibrin molecules, thus stabilizing the fibrin clot. Factor XIII deficiency is classified into two categories: type I deficiency, characterized by the lack of both the A and B subunits; and type II deficiency, characterized by the lack of the A subunit alone. These defects can result in a lifelong bleeding tendency, defective wound healing, and habitual abortion. [provided by RefSeq, Jul 2008]
UniProt Comments for F13B
F13B: The B chain of factor XIII is not catalytically active, but is thought to stabilize the A subunits and regulate the rate of transglutaminase formation by thrombin. Defects in F13B are the cause of factor XIII subunit B deficiency (FA13BD). FA13BD is an autosomal recessive disorder characterized by a life-long bleeding tendency, impaired wound healing and spontaneous abortion in affected women.

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 1q31-q32.1

Cellular Component: extracellular region

Biological Process: blood coagulation

Disease: Factor Xiii, B Subunit, Deficiency Of
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

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Organs/Tissues associated with anti-F13B antibody
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