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anti-FZD1 antibody :: Rabbit anti-Human FZD1 Polyclonal Antibody

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Catalog # MBS7053361
Unit / Price
  0.05 mg  /  $160 +1 FREE 8GB USB
  0.1 mg  /  $235 +1 FREE 8GB USB
Product Name

FZD1, Polyclonal Antibody

Popular Item
Also Known As

FZD1 Antibody

Product Synonym Names
Frizzled-1; Fz-1; hFz1; FzE1; FZD1
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Length
647
OMIM
AF072872 mRNA
3D Structure
ModBase 3D Structure for Q9UP38
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Purity/Purification
>95%, Protein G purified
Form/Format
Liquid
Immunogen
Recombinant Human Frizzled-1 protein (73-322AA)
Conjugation
Non-conjugated
Preservative
0.03% Proclin 300
Constituents
50% Glycerol, 0.01M PBS, pH 7.4
Preparation and Storage
Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Other Notes
Small volumes of anti-FZD1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-FZD1 antibody
Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Activated by Wnt3A, Wnt3, Wnt1 and to a lesser extent Wnt2, but not by Wnt4, Wnt5A, Wnt5B, Wnt6, Wnt7A or Wnt7B.
Applications Tested/Suitable for anti-FZD1 antibody
ELISA (EIA), Immunohistochemistry (IHC), Immunofluorescence (IF)
Application Notes for anti-FZD1 antibody
IHC: 1:20-1:200
IF: 1:50-1:200

Immunohistochemistry (IHC) of anti-FZD1 antibody
Immunohistochemistry of paraffin-embedded human prostate cancer using MBS7053361 at dilution of 1:100
anti-FZD1 antibody Immunohistochemistry (IHC) (IHC) image
Immunohistochemistry (IHC) of anti-FZD1 antibody
Immunohistochemistry of paraffin-embedded human kidney tissue using MBS7053361 at dilution of 1:100
anti-FZD1 antibody Immunohistochemistry (IHC) (IHC) image
Immunohistochemistry (IHC) of anti-FZD1 antibody
Immunofluorescent analysis of MCF-7 cells using MBS7053361 at a dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
anti-FZD1 antibody Immunohistochemistry (IHC) (IHC) image
NCBI/Uniprot data below describe general gene information for FZD1. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
71,158 Da
NCBI Official Full Name
frizzled-1
NCBI Official Synonym Full Names
frizzled class receptor 1
NCBI Official Symbol
NCBI Protein Information
frizzled-1
UniProt Protein Name
Frizzled-1
UniProt Synonym Protein Names
FzE1
Protein Family
UniProt Gene Name
UniProt Synonym Gene Names
Fz-1; hFz1  [Similar Products]
NCBI Summary for FZD1
Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The FZD1 protein contains a signal peptide, a cysteine-rich domain in the N-terminal extracellular region, 7 transmembrane domains, and a C-terminal PDZ domain-binding motif. The FZD1 transcript is expressed in various tissues. [provided by RefSeq, Jul 2008]
UniProt Comments for FZD1
FZD1: Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK- 3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Activated by Wnt3A, Wnt3, Wnt1 and to a lesser extent Wnt2, but not by Wnt4, Wnt5A, Wnt5B, Wnt6, Wnt7A or Wnt7B. Belongs to the G-protein coupled receptor Fz/Smo family.

Protein type: GPCR, Fz/Smo family; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR

Chromosomal Location of Human Ortholog: 7q21.13

Cellular Component: cell surface; focal adhesion; integral to membrane; plasma membrane

Molecular Function: frizzled binding; G-protein coupled receptor activity; PDZ domain binding; protein binding; receptor binding; Wnt receptor activity; Wnt-protein binding

Biological Process: cell-cell signaling; neuron differentiation; positive regulation of transcription factor activity; positive regulation of transcription, DNA-dependent; response to drug; Wnt receptor signaling pathway through beta-catenin; Wnt receptor signaling pathway, planar cell polarity pathway
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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