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anti-G6PC antibody :: Rabbit anti-Human G6PC Polyclonal Antibody

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Catalog # MBS7000964
Unit / Price
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  0.05 mg  /  $160 +1 FREE 8GB USB
  0.1 mg  /  $235 +1 FREE 8GB USB
Immunohistochemistry (IHC)
Product Name

G6PC, Polyclonal Antibody

Popular Item
Full Product Name

G6PC Antibody

Product Synonym Names
Glucose-6-phosphatase; G-6-Pase; G6Pase; Glucose-6-phosphatase alpha; G6Pase-alpha; G6PC; G6PT
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
OMIM
232200
3D Structure
ModBase 3D Structure for P35575
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Purity/Purification
>95%,Protein G purified
Form/Format
Liquid
Immunogen
Recombinant human Glucose-6-phosphatase protein
Conjugation
Non-conjugated
Storage Buffer
Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Santa Cruz Alternative
Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-27196 / sc-27198 / sc-25840
Preparation and Storage
Shipped at 4 degree C. Upon delivery, aliquot and store at -20 degree C or -80 degree C.
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Other Notes
Small volumes of anti-G6PC antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-G6PC antibody
Hydrolyzes glucose-6-phosphate to glucose in the endoplasmic reticulum. Forms with the glucose-6-phosphate transporter (SLC37A4/G6PT) the complex responsible for glucose production through glycogenolysis and gluconeogenesis. Hence, it is the key enzyme in homeostatic regulation of blood glucose levels.
Applications Tested/Suitable for anti-G6PC antibody
ELISA (EIA), Immunohistochemistry (IHC)

Immunohistochemistry (IHC) of anti-G6PC antibody
Immunohistochemistry of paraffin-embedded human liver tissue using MBS7000964 at dilution of 1:100
anti-G6PC antibody Immunohistochemistry (IHC) (IHC) image
NCBI/Uniprot data below describe general gene information for G6PC. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
20,209 Da
NCBI Official Full Name
glucose-6-phosphatase isoform 1
NCBI Official Synonym Full Names
glucose-6-phosphatase, catalytic subunit
NCBI Official Symbol
NCBI Official Synonym Symbols
G6PT; GSD1; G6PC1; GSD1a
  [Similar Products]
NCBI Protein Information
glucose-6-phosphatase
UniProt Protein Name
Glucose-6-phosphatase
UniProt Synonym Protein Names
Glucose-6-phosphatase alpha; G6Pase-alpha
Protein Family
UniProt Gene Name
UniProt Synonym Gene Names
G6PT; G-6-Pase; G6Pase; G6Pase-alpha  [Similar Products]
UniProt Entry Name
G6PC_HUMAN
NCBI Summary for G6PC
Glucose-6-phosphatase (G6Pase) is a multi-subunit integral membrane protein of the endoplasmic reticulum that is composed of a catalytic subunit and transporters for G6P, inorganic phosphate, and glucose. This gene (G6PC) is one of the three glucose-6-phosphatase catalytic-subunit-encoding genes in human: G6PC, G6PC2 and G6PC3. Glucose-6-phosphatase catalyzes the hydrolysis of D-glucose 6-phosphate to D-glucose and orthophosphate and is a key enzyme in glucose homeostasis, functioning in gluconeogenesis and glycogenolysis. Mutations in this gene cause glycogen storage disease type I (GSD1). This disease, also known as von Gierke disease, is a metabolic disorder characterized by severe hypoglycemia associated with the accumulation of glycogen and fat in the liver and kidneys.[provided by RefSeq, Feb 2011]
UniProt Comments for G6PC
G6PC: Hydrolyzes glucose-6-phosphate to glucose in the endoplasmic reticulum. Forms with the glucose-6-phosphate transporter (SLC37A4/G6PT) the complex responsible for glucose production through glycogenolysis and gluconeogenesis. Hence, it is the key enzyme in homeostatic regulation of blood glucose levels. Defects in G6PC are the cause of glycogen storage disease type 1A (GSD1A). A metabolic disorder characterized by impairment of terminal steps of glycogenolysis and gluconeogenesis. Patients manifest a wide range of clinical symptoms and biochemical abnormalities, including hypoglycemia, severe hepatomegaly due to excessive accumulation of glycogen, kidney enlargement, growth retardation, lactic acidemia, hyperlipidemia, and hyperuricemia. Belongs to the glucose-6-phosphatase family.

Protein type: Endoplasmic reticulum; Carbohydrate Metabolism - starch and sucrose; Carbohydrate Metabolism - glycolysis and gluconeogenesis; Phosphatase (non-protein); Membrane protein, multi-pass; Transporter, SLC family; Transporter; Carbohydrate Metabolism - galactose; EC 3.1.3.9; Membrane protein, integral

Chromosomal Location of Human Ortholog: 17q21

Cellular Component: endoplasmic reticulum membrane; integral to endoplasmic reticulum membrane; integral to membrane

Molecular Function: glucose-6-phosphatase activity; phosphate binding; phosphotransferase activity, alcohol group as acceptor

Biological Process: carbohydrate metabolic process; cholesterol homeostasis; gluconeogenesis; glucose 6-phosphate metabolic process; glucose homeostasis; glucose transport; glucose-6-phosphate transport; glycogen catabolic process; glycogen metabolic process; hexose transport; multicellular organism growth; phosphorylated carbohydrate dephosphorylation; regulation of gene expression; response to food; steroid metabolic process; transmembrane transport; triacylglycerol metabolic process; urate metabolic process

Disease: Glycogen Storage Disease Ia
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Organs/Tissues associated with anti-G6PC antibody
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