NP_001191236.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Related Accession #
NCBI Official Full Name
vitamin D-binding protein isoform 3
NCBI Official Synonym Full Names
GC vitamin D binding protein
NCBI Official Synonym Symbols
DBP; VDB; GRD3; VDBG; VDBP; GcMAF; DBP/GC; Gc-MAF; DBP-maf; HEL-S-51 [Similar Products]
NCBI Protein Information
vitamin D-binding protein
UniProt Protein Name
Vitamin D-binding protein
UniProt Synonym Protein Names
Gc-globulin; Group-specific component
UniProt Synonym Gene Names
UniProt Entry Name
VTDB_HUMAN
NCBI Summary for GC/VDBP
The protein encoded by this gene belongs to the albumin gene family. It is a multifunctional protein found in plasma, ascitic fluid, cerebrospinal fluid and on the surface of many cell types. It binds to vitamin D and its plasma metabolites and transports them to target tissues. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Feb 2011]
UniProt Comments for GC/VDBP
GC: Multifunctional protein found in plasma, ascitic fluid, cerebrospinal fluid, and urine and on the surface of many cell types. In plasma, it carries the vitamin D sterols and prevents polymerization of actin by binding its monomers. DBP associates with membrane-bound immunoglobulin on the surface of B-lymphocytes and with IgG Fc receptor on the membranes of T-lymphocytes. Belongs to the ALB/AFP/VDB family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Secreted, signal peptide; Secreted
Chromosomal Location of Human Ortholog: 4q12-q13
Cellular Component: extracellular space; lysosomal lumen; extracellular region; cytosol
Molecular Function: vitamin D binding; actin binding; vitamin transporter activity
Biological Process: steroid metabolic process; vitamin transport; vitamin D metabolic process
Disease: Graves Disease, Susceptibility To, 1
Research Articles on GC/VDBP
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Products associated with anti-GC/VDBP antibody
Pathways associated with anti-GC/VDBP antibody
Diseases associated with anti-GC/VDBP antibody
Organs/Tissues associated with anti-GC/VDBP antibody
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