NP_000161.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
112,730 Da
NCBI Official Full Name
glycine dehydrogenase (decarboxylating), mitochondrial
NCBI Official Synonym Full Names
glycine decarboxylase
NCBI Protein Information
glycine dehydrogenase (decarboxylating), mitochondrial
UniProt Protein Name
Glycine dehydrogenase (decarboxylating), mitochondrial
UniProt Synonym Protein Names
Glycine cleavage system P protein; Glycine decarboxylase2 PublicationsManual assertion based on opinion iniRef.1"Structural and expression analyses of normal and mutant mRNA encoding glycine decarboxylase: three-base deletion in mRNA causes nonketotic hyperglycinemia."Kure S., Narisawa K., Tada K.Biochem. Biophys. Res. Commun. 174:1176-1182(1991) [PubMed] [Europe PMC] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA], CATALYTIC ACTIVITY, VARIANT NKH PHE-756 DEL.
NCBI Summary for GLDC
Degradation of glycine is brought about by the glycine cleavage system, which is composed of four mitochondrial protein components: P protein (a pyridoxal phosphate-dependent glycine decarboxylase), H protein (a lipoic acid-containing protein), T protein (a tetrahydrofolate-requiring enzyme), and L protein (a lipoamide dehydrogenase). The protein encoded by this gene is the P protein, which binds to glycine and enables the methylamine group from glycine to be transferred to the T protein. Defects in this gene are a cause of nonketotic hyperglycinemia (NKH).[provided by RefSeq, Jan 2010]
UniProt Comments for GLDC
The glycine cleavage system catalyzes the degradation of glycine. The P protein (GLDC) binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein (GCSH).
Research Articles on GLDC
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Products associated with anti-GLDC antibody
Pathways associated with anti-GLDC antibody
Diseases associated with anti-GLDC antibody
Organs/Tissues associated with anti-GLDC antibody
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