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anti-GPR132 antibody :: Rabbit anti-Human GPR132 / G2A Polyclonal Antibody

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Catalog # MBS240904
Unit / Price
  0.05 mg  /  $530 +1 FREE 8GB USB
Immunohistochemistry (IHC)
Product Name

GPR132 / G2A, Polyclonal Antibody

Also Known As

Rabbit Polyclonal to Human GPR132 / G2A

Product Synonym Names
Anti-GPR132 / G2A Antibody (C-Terminus) IHC-plus; GPR132; G2A; G protein-coupled receptor 132; G protein-coupled receptor G2A; G2 accumulation protein; G2a receptor; Human GPR132; G2A
Product Synonym Gene Name
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Length
380
OMIM
606167
3D Structure
ModBase 3D Structure for Q9UNW8
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human
Specificity
Human GPR132 / G2A. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
Purity/Purification
Immunoaffinity Purified
Form/Format
PBS, 0.1% sodium azide.
Concentration
1 mg/ml (lot specific)
Target Species
Human
Immunogen Description
Synthetic 18 amino acid peptide from C-terminus of human GPR132 / G2A. Percent identity with other species by BLAST analysis: Human (100%); Gorilla, Marmoset (89%); Gibbon, Monkey (83%).
Immunogen Type
Synthetic peptide
Immunogen
GPR132 / G2A antibody was raised against synthetic 18 amino acid peptide from C-terminus of human GPR132 / G2A. Percent identity with other species by BLAST analysis: Human (100%); Gorilla, Marmoset (89%); Gibbon, Monkey (83%).
Antigen Modification
C-Terminus
Preparation and Storage
Long term: -70 degree C; Short term: +4 degree C
Other Notes
Small volumes of anti-GPR132 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-GPR132 antibody
G2A belongs to the Lysophospholipid/Lysosphingolipid Receptor family and is an anti-proliferative cell cycle regulator that plays a critical role in controlling peripheral lymphocyte homeostasis. Loss of G2A expression leads to the development of a late-onset autoimmune syndrome (Le et al, 2001). Lysophosphatidylcholine (LPC) is the activating ligand for G2A.
Applications Tested/Suitable for anti-GPR132 antibody
Immunohistochemistry (IHC - Paraffin), ELISA (EIA)
Application Notes for anti-GPR132 antibody
ELISA, IHC-P (12 ug/ml)
Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary anti...

Immunohistochemistry (IHC) of anti-GPR132 antibody
Anti-GPR132 / G2A antibody IHC of human spleen. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
anti-GPR132 antibody Immunohistochemistry (IHC) (IHC) image
NCBI/Uniprot data below describe general gene information for GPR132. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
41,462 Da
NCBI Official Full Name
probable G-protein coupled receptor 132 isoform 1
NCBI Official Synonym Full Names
G protein-coupled receptor 132
NCBI Official Symbol
GPR132  [Similar Products]
NCBI Official Synonym Symbols
NCBI Protein Information
probable G-protein coupled receptor 132; G2 accumulation protein
UniProt Protein Name
Probable G-protein coupled receptor 132
UniProt Synonym Protein Names
G2 accumulation protein
UniProt Gene Name
GPR132  [Similar Products]
UniProt Synonym Gene Names
UniProt Entry Name
GP132_HUMAN
NCBI Summary for GPR132
This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor (GPCR) superfamily. The receptors are seven-pass transmembrane proteins that respond to extracellular cues and activate intracellular signal transduction pathways. This protein was reported to be a receptor for lysophosphatidylcholine action, but PubMedID: 15653487 retracts this finding and instead suggests this protein to be an effector of lysophosphatidylcholine action. This protein may have proton-sensing activity and may be a receptor for oxidized free fatty acids. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
UniProt Comments for GPR132
GPR132: Receptor for an unknown ligand. Activates a G alpha protein, most likely G alpha(q). May be involved in apoptosis. Functions at the G2/M checkpoint to delay mitosis. May serve as a mechanism for T- and B-cells, and other cell types, to slow their proliferation and repair damaged DNA to ensure proper replication. Belongs to the G-protein coupled receptor 1 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Receptor, GPCR; Membrane protein, multi-pass; GPCR, family 1; Membrane protein, integral

Chromosomal Location of Human Ortholog: 14q32.3

Cellular Component: plasma membrane; integral to membrane

Molecular Function: G-protein coupled receptor activity

Biological Process: G-protein coupled receptor protein signaling pathway; G1/S transition of mitotic cell cycle
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Products associated withanti-GPR132 antibody
Diseases associated with anti-GPR132 antibody
Organs/Tissues associated with anti-GPR132 antibody
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