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anti-GPR44 antibody :: Rabbit anti-Human GPR44 Polyclonal Antibody

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Catalog # MBS535481
Unit / Price
  0.05 mg  /  $540 +1 FREE 8GB USB
anti-GPR44 antibody
Product Name

GPR44, Polyclonal Antibody

Also Known As

GPR44 antibody

Product Synonym Names
Polyclonal GPR44; Anti-GPR44; hCRTH2; gpr44; GPR -44; DP2 prostaglandin receptor; GPR44; chemoattractant receptor-homologous molecule expressed on th2; GPR 44; crth2; G protein-coupled receptor 44; prostaglandin D(2) (PGD(2)) receptor
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Length
395
OMIM
604837
3D Structure
ModBase 3D Structure for Q9Y5Y4
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human
Purity/Purification
GPR44 antibody was purified by affinity chromatography.
Form/Format
Purified by Immunoaffinity Chromatography and supplied in PBS with 0.1% NaN3.
Concentration
1.0 mg/ml (lot specific)
Biological Significance
G protein-coupled receptors (GPCRs), comprise a large protein family of transmembrane receptors that sense molecules outside the cell and activate inside signal transduction pathways and, ultimately, cellular responses. G protein-coupled receptors are found only in eukaryotes, including yeast, choanoflagellates, and animals. GPR44 has recently been found to belong to the prostanoid receptor family and named DP2, with this becoming the official IUPHAR nomenclature.
Biohazard Information
This product contains sodium azide as preservative. Although the amount of sodium azide is very small appropriate care must be taken when handling.
Immunogen
GPR44 antibody was raised in rabbit using a synthetic peptide conjugated to KLH as the immunogen.
Preparation and Storage
Store at 4 degree C for short term storage. Aliquot and store at -70 degree C for long term storage. Avoid repeated freeze/thaw cycles.
Other Notes
Small volumes of anti-GPR44 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-GPR44 antibody
Rabbit polyclonal GPR44 antibody
Product Categories/Family for anti-GPR44 antibody
Applications Tested/Suitable for anti-GPR44 antibody
Immunohistochemistry (IHC) Paraffin
Application Notes for anti-GPR44 antibody
IHC-P: 15 ug/ml
NCBI/Uniprot data below describe general gene information for GPR44. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
43,268 Da
NCBI Official Full Name
G protein-coupled receptor 44
NCBI Official Synonym Full Names
prostaglandin D2 receptor 2
NCBI Official Symbol
PTGDR2  [Similar Products]
NCBI Official Synonym Symbols
DP2; DL1R; CD294; CRTH2; GPR44
  [Similar Products]
NCBI Protein Information
prostaglandin D2 receptor 2
UniProt Protein Name
Prostaglandin D2 receptor 2
UniProt Synonym Protein Names
Chemoattractant receptor-homologous molecule expressed on Th2 cells; G-protein coupled receptor 44; CD_antigen: CD294
UniProt Gene Name
PTGDR2  [Similar Products]
UniProt Synonym Gene Names
CRTH2; DL1R; GPR44  [Similar Products]
UniProt Entry Name
PD2R2_HUMAN
NCBI Summary for GPR44
This gene encodes a G-protein-coupled receptor that is preferentially expressed in CD4+ effector T helper 2 (Th2) cells. This protein is a prostaglandin D2 receptor that mediates the pro-inflammatory chemotaxis of eosinophils, basophils, and Th2 lymphocytes generated during allergic inflammation. Single nucleotide polymorphisms in the 3' UTR of this gene have been associated with asthma susceptibility.[provided by RefSeq, Mar 2011]
UniProt Comments for GPR44
GPR44: Receptor for prostaglandin D2 (PGD2). Coupled to the G(i)-protein. Receptor activation may result in pertussis toxin- sensitive decreases in cAMP levels and Ca(2+) mobilization. PI3K signaling is also implicated in mediating PTGDR2 effects. PGD2 induced receptor internalization. CRTH2 internalization can be regulated by diverse kinases such as, PKC, PKA, ADRBK1/GRK2, GPRK5/GRK5 and GRK6. Receptor activation is responsible, at least in part, in immune regulation and allergic/inflammation responses. Belongs to the G-protein coupled receptor 1 family.

Protein type: Membrane protein, multi-pass; Receptor, GPCR; GPCR, family 1; Membrane protein, integral

Chromosomal Location of Human Ortholog: 11q12-q13.3

Cellular Component: neuron projection; integral to plasma membrane; plasma membrane

Molecular Function: G-protein coupled receptor activity; neuropeptide binding; prostaglandin F receptor activity; prostaglandin J receptor activity; prostaglandin D receptor activity

Biological Process: synaptic transmission; G-protein coupled receptor protein signaling pathway; G-protein signaling, coupled to cyclic nucleotide second messenger; neuropeptide signaling pathway; positive regulation of G-protein coupled receptor protein signaling pathway; calcium-mediated signaling; immune response; G-protein signaling, adenylate cyclase inhibiting pathway; chemotaxis
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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