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anti-GSTM1 antibody :: Goat GSTM1/GSTM2 Polyclonal Antibody

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Catalog # MBS420063
Unit / Price
  0.1 mg  /  $300 +1 FREE 8GB USB
Western Blot (WB)
Product Name

GSTM1/GSTM2, Polyclonal Antibody

Also Known As

Goat anti-GSTM1/GSTM2 Antibody

Product Synonym Names
GSTM1; GSTM2; MU; H-B; GST1; GTH4; GTM1; MU-1; GSTM1-1; MGC26563; GSTM1a-1a; GSTM1b-1b; glutathione S-transferase M1; HB subunit 4; GST class-mu 1; glutathione S-aryltransferase; glutathione S-alkyltransferase; glutathione S-transferase, Mu-1; glutathione; GSTM1 antibody; GSTM2 antibody; MU antibody; H-B antibody; GST1 antibody; GTH4 antibody; GTM1 antibody; MU-1 antibody; GSTM1-1 antibody; MGC26563 antibody; GSTM1a-1a antibody; GSTM1b-1b antibody; glutathione S-transferase M1 antibody; HB subunit 4 antibody; GST class-mu 1 antibody; glutathione S-aryltransferase antibody; glutathione S-alkyltransferase antibody; glutathione S-transferase; Mu-1 antibody; glutathione S-aralkyltransferase antibody; S-(hydroxyalkyl)glutathione lyase antibody; glutathione S-transferase mu 1 antibody; glutathione S-transferase mu 2 (muscle) antibody; GST4 antibody; GSTM antibody; GSTM2-2 antibody; GTHMUS antibody; MGC117303 antibody; GST class-mu 2 antibody; GST; muscle antibody; S-(hydroxyalkyl)glutathione lyase M2 antibody; glutathione S-alkyltransferase M2 antibody; glutathione S-aralkyltransferase M2 antibody; glutathione S-aryltransferase M2 antibody; glutathione S-transferase 4 antibody; glutathione S-transferase M1 antibody; glutathione S-transferase M2 (muscle) antibody; glutathione S-transferase mu 2 antibody; GSTM1 / GSTM2
Product Synonym Gene Name
Antibody/Peptide Pairs
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Length
218
Immunogen Sequence
CVFSKMAVWG NK
OMIM
138350
Clonality
Polyclonal
Host
Goat
Species Reactivity
Tested: Human; Expected from sequence similarity: Human
Purity/Purification
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Form/Format
Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
Concentration
100ug specific antibody in 200ul (lot specific)
Immunogen
Peptide with sequence CVFSKMAVWGNK, from the C Terminus of the protein sequence according to NP_000552.2; NP_666533.1; NP_000839.1.
Epitope
C Terminus
Note
This antibody is expected to recognise both reported variants of human GSTM1 protein (NP_000552.2; NP_666533.1) and wil also recognise human GSTM2 protein (NP_000839.1).
Preparation and Storage
Aliquot and store at -20 degree C. Minimize freezing and thawing.
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Other Notes
Small volumes of anti-GSTM1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-GSTM1 antibody
Peptide ELISA (EIA), Western Blot (WB)
Application Notes for anti-GSTM1 antibody
Peptide ELISA: Antibody detection limit dilution 1: 1000.
Western Blot: Approx 26kDa band observed in Human Liver and Human Lung lysates (calculated MW of 25.7kDa according to NP_000552.2, and NP_000839.1). Recommended concentration: 1-3ug/ml.

Western Blot (WB) of anti-GSTM1 antibody
(0.3ug/ml) staining of Human Lung lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
anti-GSTM1 antibody Western Blot (WB) (WB) image
NCBI/Uniprot data below describe general gene information for GSTM1. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI Related Accession #
Manufactured in an ISO 9001:2015 Certified Laboratory.NP_666533.1; NP_000839.1[Other Products]
NCBI GenBank Nucleotide #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
21,253 Da
NCBI Official Full Name
glutathione S-transferase Mu 1 isoform 1
NCBI Official Synonym Full Names
glutathione S-transferase mu 1
NCBI Official Symbol
GSTM1  [Similar Products]
NCBI Official Synonym Symbols
MU; H-B; GST1; GTH4; GTM1; MU-1; GSTM1-1; GSTM1a-1a; GSTM1b-1b
  [Similar Products]
NCBI Protein Information
glutathione S-transferase Mu 1
UniProt Protein Name
Glutathione S-transferase Mu 1
UniProt Synonym Protein Names
GST HB subunit 4; GST class-mu 1; GSTM1-1; GSTM1a-1a; GSTM1b-1b; GTH4
Protein Family
UniProt Gene Name
GSTM1  [Similar Products]
UniProt Synonym Gene Names
UniProt Entry Name
GSTM1_HUMAN
NCBI Summary for GSTM1
Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-transferase that belongs to the mu class. The mu class of enzymes functions in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione. The genes encoding the mu class of enzymes are organized in a gene cluster on chromosome 1p13.3 and are known to be highly polymorphic. These genetic variations can change an individual's susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of certain drugs. Null mutations of this class mu gene have been linked with an increase in a number of cancers, likely due to an increased susceptibility to environmental toxins and carcinogens. Multiple protein isoforms are encoded by transcript variants of this gene. [provided by RefSeq, Jul 2008]
UniProt Comments for GSTM1
GSTM1: Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Belongs to the GST superfamily. Mu family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Other Amino Acids Metabolism - glutathione; EC 2.5.1.18; Xenobiotic Metabolism - metabolism by cytochrome P450; Xenobiotic Metabolism - drug metabolism - cytochrome P450; Transferase

Chromosomal Location of Human Ortholog: 1p13.3

Cellular Component: cytoplasm; cytosol

Molecular Function: enzyme binding; glutathione binding; glutathione transferase activity; protein homodimerization activity

Biological Process: glutathione metabolic process; nitrobenzene metabolic process; xenobiotic catabolic process
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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