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anti-HCII antibody :: Rabbit anti-Human Heparin Cofactor II (HCII) Polyclonal Antibody

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Catalog # MBS2091807
Unit / Price
  0.01 mg  /  $110 +1 FREE 8GB USB
  0.02 mg  /  $130 +1 FREE 8GB USB
  0.05 mg  /  $175 +1 FREE 8GB USB
  0.1 mg  /  $225 +1 FREE 8GB USB
  0.2 mg  /  $335 +1 FREE 8GB USB
  1 mg  /  $795 +1 FREE 8GB USB
anti-HCII antibody
Product Name

Heparin Cofactor II (HCII), Polyclonal Antibody

Also Known As

Biotin-Linked Polyclonal Antibody to Heparin Cofactor II (HCII)

Product Synonym Names
SERPIND1; HC2; HCF2; HC II; HLS2; LS2; Serpin D1; Serpin Peptidase Inhibitor Clade D Member 1; Protease inhibitor leuserpin-2
Matching Pairs
Matching Pairs
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Length
499
OMIM
M12849 mRNA
3D Structure
ModBase 3D Structure for P05546
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human
Concentration
200ug/ml (lot specific)
Conjugation
Biotin
Immunogen
HCII (Asp276~Ser499)
Other Notes
Small volumes of anti-HCII antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-HCII antibody
Western Blot (WB), Immunohistochemistry (IHC)
NCBI/Uniprot data below describe general gene information for HCII. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
57,071 Da
NCBI Official Full Name
heparin cofactor 2
NCBI Official Synonym Full Names
serpin family D member 1
NCBI Official Symbol
SERPIND1  [Similar Products]
NCBI Official Synonym Symbols
HC2; LS2; HCF2; HCII; HLS2; THPH10; D22S673
  [Similar Products]
NCBI Protein Information
heparin cofactor 2
UniProt Protein Name
Heparin cofactor 2
UniProt Synonym Protein Names
Heparin cofactor II; HC-II; Protease inhibitor leuserpin-2; HLS2; Serpin D1
UniProt Gene Name
SERPIND1  [Similar Products]
UniProt Synonym Gene Names
HCF2; HC-II; HLS2  [Similar Products]
NCBI Summary for HCII
This gene belongs to the serpin gene superfamily. Serpins play roles in many processes including inflammation, blood clotting, and cancer metastasis. Members of this family have highly conserved secondary structures with a reactive center loop that interacts with the protease active site to inhibit protease activity. This gene encodes a plasma serine protease that functions as a thrombin and chymotrypsin inhibitor. The protein is activated by heparin, dermatan sulfate, and glycosaminoglycans. Allelic variations in this gene are associated with heparin cofactor II deficiency. [provided by RefSeq, Jul 2015]
UniProt Comments for HCII
SERPIND1: Thrombin inhibitor activated by the glycosaminoglycans, heparin or dermatan sulfate. In the presence of the latter, HC-II becomes the predominant thrombin inhibitor in place of antithrombin III (AT-III). Also inhibits chymotrypsin, but in a glycosaminoglycan-independent manner. Defects in SERPIND1 are the cause of thrombophilia due to heparin cofactor 2 deficiency (THPH10). A hemostatic disorder characterized by a tendency to recurrent thrombosis. Belongs to the serpin family.

Chromosomal Location of Human Ortholog: 22q11.21

Cellular Component: endoplasmic reticulum lumen; extracellular region; extracellular space

Molecular Function: endopeptidase inhibitor activity; heparin binding; serine-type endopeptidase inhibitor activity

Biological Process: bioluminescence; blood coagulation; cellular protein metabolic process; chemotaxis; post-translational protein modification

Disease: Heparin Cofactor Ii Deficiency
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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