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anti-HIST1H1D antibody :: Rabbit anti-Human HIST1H1D Polyclonal Antibody

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Catalog # MBS9205124
Unit / Price
  0.08 mL  /  $165 +1 FREE 8GB USB
  0.4 mL  /  $370 +1 FREE 8GB USB
Product Name

HIST1H1D, Polyclonal Antibody

Popular Item
Also Known As

HIST1H1D Antibody (Center)

Product Synonym Names
Histone H13; Histone H1c; Histone H1s-2; HIST1H1D; H1F3
Antibody/Peptide Pairs
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Positions
135-164
Immunogen Sequence Length
221
OMIM
142210
3D Structure
ModBase 3D Structure for P16402
Clonality
Polyclonal
Isotype
Rabbit Ig
Clone Number
RB33733
Host
Rabbit
Species Reactivity
Human
Specificity
This HIST1H1D antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 135-164 amino acids from the Central region of human HIST1H1D.
Purity/Purification
Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Form/Format
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Function
Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Acts also as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation (By similarity).
Cellular Location
Nucleus. Chromosome. Note=According to PubMed:15911621 more commonly found in euchromatin. According to PubMed:10997781 is associated with inactive chromatin
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 2 weeks. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
Other Notes
Small volumes of anti-HIST1H1D antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-HIST1H1D antibody
Histones are basic nuclear proteins responsible for
nucleosome structure of the chromosomal fiber in eukaryotes. Two
molecules of each of the four core histones (H2A, H2B, H3, and H4)
form an octamer, around which approximately 146 bp of DNA is
wrapped in repeating units, called nucleosomes. The linker histone,
H1, interacts with linker DNA between nucleosomes and functions in
the compaction of chromatin into higher order structures. This gene
is intronless and encodes a member of the histone H1 family.
Transcripts from this gene lack polyA tails but instead contain a
palindromic termination element. This gene is found in the large
histone gene cluster on chromosome 6.
Applications Tested/Suitable for anti-HIST1H1D antibody
Western Blot (WB), ELISA (EIA), Immunohistochemistry (IHC)
Application Notes for anti-HIST1H1D antibody
WB~~1:1000
IHC-P~~1:10~50

Western Blot (WB) of anti-HIST1H1D antibody
HIST1H1D Antibody (Center) western blot analysis in MDA-MB231 cell line lysates (35ug/lane).This demonstrates the HIST1H1D antibody detected the HIST1H1D protein (arrow).
anti-HIST1H1D antibody Western Blot (WB) (WB) image
Immunohistochemistry (IHC) of anti-HIST1H1D antibody
HIST1H1D Antibody (Center) immunohistochemistry analysis in formalin fixed and paraffin embedded human breast carcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of HIST1H1D Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.
anti-HIST1H1D antibody Immunohistochemistry (IHC) (IHC) image
NCBI/Uniprot data below describe general gene information for HIST1H1D. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
22350
NCBI Official Full Name
histone H1.3
NCBI Official Synonym Full Names
histone cluster 1, H1d
NCBI Official Symbol
HIST1H1D  [Similar Products]
NCBI Official Synonym Symbols
H1D; H1.3; H1F3; H1s-2
  [Similar Products]
NCBI Protein Information
histone H1.3
UniProt Protein Name
Histone H1.3
UniProt Synonym Protein Names
Histone H1c; Histone H1s-2
UniProt Gene Name
HIST1H1D  [Similar Products]
UniProt Synonym Gene Names
UniProt Entry Name
H13_HUMAN
NCBI Summary for HIST1H1D
Histones are basic nuclear proteins responsible for nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a member of the histone H1 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6. [provided by RefSeq, Jul 2008]
UniProt Comments for HIST1H1D
H1D: Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Acts also as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation. Belongs to the histone H1/H5 family.

Protein type: DNA-binding

Chromosomal Location of Human Ortholog: 6p21.3

Cellular Component: nuclear chromatin; nucleosome

Molecular Function: chromatin DNA binding

Biological Process: nucleosome assembly; nucleosome positioning
Product References and Citations for anti-HIST1H1D antibody
Kim, J.J., et al. J. Hum. Genet. 55(1):27-31(2010)
Soranzo, N., et al. PLoS Genet. 5 (4), E1000445 (2009) :
Sovio, U., et al. PLoS Genet. 5 (3), E1000409 (2009) :
Gudbjartsson, D.F., et al. Nat. Genet. 40(5):609-615(2008)
Lettre, G., et al. Nat. Genet. 40(5):584-591(2008)

Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

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