NP_002111.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
Observed: 31 kD Predicted: 31 kDa
NCBI Official Full Name
HLA class II histocompatibility antigen, DO beta chain
NCBI Official Synonym Full Names
major histocompatibility complex, class II, DO beta
NCBI Official Synonym Symbols
NCBI Protein Information
HLA class II histocompatibility antigen, DO beta chain
UniProt Protein Name
HLA class II histocompatibility antigen, DO beta chain
UniProt Synonym Protein Names
MHC class II antigen DOB
NCBI Summary for HLA-DOB
HLA-DOB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DOA) and a beta chain (DOB), both anchored in the membrane. It is located in intracellular vesicles. DO suppresses peptide loading of MHC class II molecules by inhibiting HLA-DM. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. [provided by RefSeq, Jul 2008]
UniProt Comments for HLA-DOB
Important modulator in the HLA class II restricted antigen presentation pathway by interaction with the HLA-DM molecule in B-cells. Modifies peptide exchange activity of HLA-DM.
Research Articles on HLA-DOB
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Disclaimer
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Products associated with anti-HLA-DOB antibody
Pathways associated with anti-HLA-DOB antibody
Diseases associated with anti-HLA-DOB antibody
Organs/Tissues associated with anti-HLA-DOB antibody
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