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anti-HNRNPL antibody :: Rabbit anti-Human HNRNPL Polyclonal Antibody

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Catalog # MBS1491998
Unit / Price
  0.05 mg  /  $160 +1 FREE 8GB USB
  0.1 mg  /  $235 +1 FREE 8GB USB
Product Name

HNRNPL, Polyclonal Antibody

Popular Item
Also Known As

HNRNPL Antibody

Product Synonym Names
Heterogeneous nuclear ribonucleoprotein L; hnRNP L; HNRNPL; HNRPL; P/OKcl.14
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Length
456
OMIM
164021
3D Structure
ModBase 3D Structure for P14866
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Purity/Purification
>95%, Protein G Purified
Storage Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Conjugate
Non-conjugated
Immunogen
Recombinant human Heterogeneous nuclear ribonucleoprotein L protein
Santa Cruz Alternative
Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-16550 / sc-30720 / sc-28726
Preparation and Storage
Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Other Notes
Small volumes of anti-HNRNPL antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-HNRNPL antibody
Splicing factor binding to exonic or intronic sites and acting as either an activator or repressor of exon inclusion. Exhibits a binding preference for CA-rich elements. Component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes and associated with most nascent transcripts. Associates, together with APEX1, to the negative calcium responsive element (nCaRE) B2 of the APEX2 promoter.
Applications Tested/Suitable for anti-HNRNPL antibody
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-HNRNPL antibody
Recommended dilution: IHC:1:20-1:200

Western Blot (WB) of anti-HNRNPL antibody
Western Blot
Positive WB detected in:HepG2 whole cell lysate,Mouse heart tissue,Mouse brain tissue,Mouse kidney tissue
All lanes: HNRNPL antibody at 3ug/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 65,51 kDa
Observed band size: 65 kDa

anti-HNRNPL antibody Western Blot (WB) (WB) image
Immunohistochemistry (IHC) of anti-HNRNPL antibody
Immunohistochemistry of paraffin-embedded human colon cancer using MBS1491998 at dilution of 1:100
anti-HNRNPL antibody Immunohistochemistry (IHC) (IHC) image
NCBI/Uniprot data below describe general gene information for HNRNPL. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
50,561 Da
NCBI Official Full Name
heterogeneous nuclear ribonucleoprotein L isoform b
NCBI Official Synonym Full Names
heterogeneous nuclear ribonucleoprotein L
NCBI Official Symbol
HNRNPL  [Similar Products]
NCBI Official Synonym Symbols
HNRPL; hnRNP-L; P/OKcl.14
  [Similar Products]
NCBI Protein Information
heterogeneous nuclear ribonucleoprotein L
UniProt Protein Name
Heterogeneous nuclear ribonucleoprotein L
UniProt Gene Name
HNRNPL  [Similar Products]
UniProt Synonym Gene Names
HNRPL; hnRNP L  [Similar Products]
UniProt Entry Name
HNRPL_HUMAN
NCBI Summary for HNRNPL
Heterogeneous nuclear RNAs (hnRNAs) which include mRNA precursors and mature mRNAs are associated with specific proteins to form heterogenous ribonucleoprotein (hnRNP) complexes. Heterogeneous nuclear ribonucleoprotein L is among the proteins that are stably associated with hnRNP complexes and along with other hnRNP proteins is likely to play a major role in the formation, packaging, processing, and function of mRNA. Heterogeneous nuclear ribonucleoprotein L is present in the nucleoplasm as part of the HNRP complex. HNRP proteins have also been identified outside of the nucleoplasm. Exchange of hnRNP for mRNA-binding proteins accompanies transport of mRNA from the nucleus to the cytoplasm. Since HNRP proteins have been shown to shuttle between the nucleus and the cytoplasm, it is possible that they also have cytoplasmic functions. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
UniProt Comments for HNRNPL
hnRNP L: This protein is a component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate for the processing events that pre-mRNAs undergo before becoming functional, translatable mRNAs in the cytoplasm. Is associated with most nascent transcripts including those of the landmark giant loops of amphibian lampbrush chromosomes. Associates, together with APEX1, to the negative calcium responsive element (nCaRE) B2 of the APEX2 promoter. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: RNA splicing; RNA-binding

Chromosomal Location of Human Ortholog: 19q13.2

Cellular Component: cytoplasm; membrane; nucleoplasm; nucleus; ribonucleoprotein complex

Molecular Function: nucleotide binding; protein binding; RNA binding

Biological Process: gene expression; nuclear mRNA splicing, via spliceosome; RNA processing; RNA splicing
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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