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anti-HOMER1 antibody :: Rabbit anti-Human Homer protein homolog 1 Polyclonal Antibody

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Catalog # MBS7006208
Unit / Price
  0.05 mg  /  $160 +1 FREE 8GB USB
  0.1 mg  /  $235 +1 FREE 8GB USB
Immunohistochemistry (IHC)
Product Name

Homer protein homolog 1 (HOMER1), Polyclonal Antibody

Popular Item
Also Known As

Rabbit anti-human Homer protein homolog 1 polyclonal Antibody

Product Synonym Names
Homer protein homolog 1 protein; HOMER1; SYN47
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Length
224
OMIM
604798
3D Structure
ModBase 3D Structure for Q86YM7
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Purity/Purification
Caprylic Acid Ammonium Sulfate Precipitation purified
Form/Format
Liquid
Immunogen
Recombinant human Homer protein homolog 1 protein
Conjugation
Non-conjugated
Storage Buffer
Preservative: 0.03% Proclin 300; Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Santa Cruz Alternative
Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-8923 / sc-20807 / sc-15321
Preparation and Storage
Shipped at 4 degree C. Upon delivery, aliquot and store at -20 degree C or -80 degree C.
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Other Notes
Small volumes of anti-HOMER1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-HOMER1 antibody
Postsynaptic density scaffolding protein. Binds and cross-links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER-associated ITPR1 receptors, it aids the coupling of surface receptors to intracellular calcium release. May also couple GRM1 to PI3 kinase through its interaction with AGAP2. Isoform 1 regulates the trafficking and surface expression of GRM5. Isoform 3 acts as a natural dominant negative, in dynamic competition with constitutively expressed isoform 1 to regulate synaptic metabotropic glutamate function. Isoform 3, may be involved in the structural changes that occur at synapses during long-lasting neuronal plasticity and development.

This gene encodes a member of the homer family of dendritic proteins. Members of this family regulate group 1 metabotrophic glutamate receptor function.
Product Categories/Family for anti-HOMER1 antibody
Applications Tested/Suitable for anti-HOMER1 antibody
ELISA (EIA), Immunohistochemistry (IHC)
Application Notes for anti-HOMER1 antibody
Recommended dilution: IHC: 1:20-1:200

Immunohistochemistry (IHC) of anti-HOMER1 antibody
Immunohistochemistry of paraffin-embedded LO2 cells using MBS7006208 at dilution of 1:50
anti-HOMER1 antibody Immunohistochemistry (IHC) (IHC) image
NCBI/Uniprot data below describe general gene information for HOMER1. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
19,861 Da
NCBI Official Full Name
homer protein homolog 1 isoform 2
NCBI Official Synonym Full Names
homer scaffolding protein 1
NCBI Official Symbol
HOMER1  [Similar Products]
NCBI Official Synonym Symbols
HOMER; SYN47; Ves-1; HOMER1A; HOMER1B; HOMER1C
  [Similar Products]
NCBI Protein Information
homer protein homolog 1
UniProt Protein Name
Homer protein homolog 1
Protein Family
UniProt Gene Name
HOMER1  [Similar Products]
UniProt Synonym Gene Names
SYN47; Homer-1  [Similar Products]
UniProt Entry Name
HOME1_HUMAN
NCBI Summary for HOMER1
This gene encodes a member of the homer family of dendritic proteins. Members of this family regulate group 1 metabotrophic glutamate receptor function. [provided by RefSeq, Jul 2008]
UniProt Comments for HOMER1
HOMER1: Postsynaptic density scaffolding protein. Binds and cross-links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER-associated ITPR1 receptors, it aids the coupling of surface receptors to intracellular calcium release. May also couple GRM1 to PI3 kinase through its interaction with AGAP2. Isoform 1 regulates the trafficking and surface expression of GRM5. Isoform 3 acts as a natural dominant negative, in dynamic competition with constitutively expressed isoform 1 to regulate synaptic metabotropic glutamate function. Isoform 3, may be involved in the structural changes that occur at synapses during long-lasting neuronal plasticity and development. Interacts with IFT57. Interacts with OPHN1. Isoform 1 encodes a coiled-coil structure that mediates homo- and heteromultimerization. Belongs to the Homer family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Adaptor/scaffold

Chromosomal Location of Human Ortholog: 5q14.2

Cellular Component: apical part of cell; axon; cell junction; costamere; postsynaptic membrane; Z disc

Molecular Function: metabotropic glutatmate receptor binding; protein binding

Biological Process: behavioral response to cocaine; chemical homeostasis within a tissue; metabotropic glutamate receptor, phospholipase C activating pathway; positive regulation of calcium ion transport; positive regulation of signal transduction; response to calcium ion; skeletal muscle contraction; skeletal muscle fiber development; synaptic transmission
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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