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anti-HRH1 antibody :: Rabbit anti-Human HRH1 Polyclonal Antibody

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Catalog # MBS7052053
Unit / Price
  0.05 mg  /  $160 +1 FREE 8GB USB
  0.1 mg  /  $235 +1 FREE 8GB USB
Product Name

HRH1, Polyclonal Antibody

Popular Item
Also Known As

HRH1 Antibody

Product Synonym Names
Histamine H1 receptor; H1R; HH1R; HRH1
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Length
487
OMIM
Z34897 mRNA
3D Structure
ModBase 3D Structure for P35367
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Purity/Purification
>95%, Protein G purified
Form/Format
Liquid
Immunogen
Recombinant Human Histamine H1 receptor protein (211-416AA)
Conjugation
Non-conjugated
Preservative
0.03% Proclin 300
Constituents
50% Glycerol, 0.01M PBS, pH 7.4
Preparation and Storage
Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Other Notes
Small volumes of anti-HRH1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-HRH1 antibody
In peripheral tissues, the H1 subclass of histamine receptors mediates the contraction of smooth muscles, increase in capillary permeability due to contraction of terminal venules, and catecholamine release from adrenal medulla, as well as mediating neurotransmission in the central nervous system.
Applications Tested/Suitable for anti-HRH1 antibody
ELISA (EIA), Immunohistochemistry (IHC), Immunofluorescence (IF)
Application Notes for anti-HRH1 antibody
IHC: 1:20-1:200
IF: 1:50-1:200

Immunohistochemistry (IHC) of anti-HRH1 antibody
Immunohistochemistry of paraffin-embedded human small intestine tissue using MBS7052053 at dilution of 1:100
anti-HRH1 antibody Immunohistochemistry (IHC) (IHC) image
Immunohistochemistry (IHC) of anti-HRH1 antibody
Immunohistochemistry of paraffin-embedded human liver tissue using MBS7052053 at dilution of 1:100
anti-HRH1 antibody Immunohistochemistry (IHC) (IHC) image
Immunohistochemistry (IHC) of anti-HRH1 antibody
Immunofluorescent analysis of HepG2 cells using MBS7052053 at a dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
anti-HRH1 antibody Immunohistochemistry (IHC) (IHC) image
Western Blot (WB) of anti-HRH1 antibody
Western Blot
Positive WB detected in: PC3 whole cell lysate
All lanes: HRH1 antibody at 2.8ug/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 56 KDa
Observed band size: 56 KDa

anti-HRH1 antibody Western Blot (WB) (WB) image
NCBI/Uniprot data below describe general gene information for HRH1. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
55,784 Da
NCBI Official Full Name
histamine H1 receptor
NCBI Official Synonym Full Names
histamine receptor H1
NCBI Official Symbol
NCBI Official Synonym Symbols
H1R; H1-R; HH1R; hisH1
  [Similar Products]
NCBI Protein Information
histamine H1 receptor
UniProt Protein Name
Histamine H1 receptor
Protein Family
UniProt Gene Name
UniProt Synonym Gene Names
H1R; HH1R  [Similar Products]
NCBI Summary for HRH1
Histamine is a ubiquitous messenger molecule released from mast cells, enterochromaffin-like cells, and neurons. Its various actions are mediated by histamine receptors H1, H2, H3 and H4. The protein encoded by this gene is an integral membrane protein and belongs to the G protein-coupled receptor superfamily. It mediates the contraction of smooth muscles, the increase in capillary permeability due to contraction of terminal venules, the release of catecholamine from adrenal medulla, and neurotransmission in the central nervous system. It has been associated with multiple processes, including memory and learning, circadian rhythm, and thermoregulation. It is also known to contribute to the pathophysiology of allergic diseases such as atopic dermatitis, asthma, anaphylaxis and allergic rhinitis. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jan 2015]
UniProt Comments for HRH1
H1R: In peripheral tissues, the H1 subclass of histamine receptors mediates the contraction of smooth muscles, increase in capillary permeability due to contraction of terminal venules, and catecholamine release from adrenal medulla, as well as mediating neurotransmission in the central nervous system. Belongs to the G-protein coupled receptor 1 family.

Protein type: GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR

Chromosomal Location of Human Ortholog: 3p25.3

Cellular Component: cytoplasm; integral to plasma membrane; nucleoplasm; plasma membrane

Molecular Function: G-protein coupled receptor activity; histamine receptor activity

Biological Process: G-protein coupled receptor protein signaling pathway; G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); inflammatory response; inositol phosphate-mediated signaling; positive regulation of inositol trisphosphate biosynthetic process; regulation of synaptic transmission; regulation of vasoconstriction
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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