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anti-HTR2A antibody :: Rabbit anti-Human HTR2A Polyclonal Antibody

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Catalog # MBS1495072
Unit / Price
Scan QR to view Datasheet
  0.05 mg  /  $160 +1 FREE 8GB USB
  0.1 mg  /  $235 +1 FREE 8GB USB
Product Name

HTR2A, Polyclonal Antibody

Popular Item
Full Product Name

HTR2A Antibody

Product Synonym Names
5-HT-2; 5-HT-2A; HTR2A; HTR2
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
OMIM
182135
3D Structure
ModBase 3D Structure for P28223
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Purity/Purification
Caprylic Acid Ammonium Sulfate Precipitation Purified
Storage Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Conjugate
Non-conjugated
Immunogen
Recombinant human 5-hydroxytryptamine receptor 2A protein
Santa Cruz Alternative
Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-15073 / sc-15074 / sc-32537 / sc-32538 / sc-50396
Preparation and Storage
Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Other Notes
Small volumes of anti-HTR2A antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-HTR2A antibody
G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances, including mescaline, psilocybin, 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI) and lysergic acid diethylamide (LSD). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling activates phospholipase C and a phosphatidylinositol-calcium second messenger system that modulates the activity of phosphatidylinositol 3-kinase and promotes the release of Ca2+ ions from intracellular stores. Affects neural activity, perception, cognition and mood. Plays a role in the regulation of behavior, including responses to anxiogenic situations and psychoactive substances. Plays a role in intestinal smooth muscle contraction, and may play a role in arterial vasoconstriction.
Applications Tested/Suitable for anti-HTR2A antibody
ELISA (EIA), Immunohistochemistry (IHC)

Immunohistochemistry (IHC) of anti-HTR2A antibody
Immunohistochemistry of paraffin-embedded human adrenal gland tissue using MBS1495072 at dilution 1:100
anti-HTR2A antibody Immunohistochemistry (IHC) (IHC) image
Immunohistochemistry (IHC) of anti-HTR2A antibody
Immunohistochemistry of paraffin-embedded human skin tissue using MBS1495072 at dilution 1:100
anti-HTR2A antibody Immunohistochemistry (IHC) (IHC) image
Immunohistochemistry (IHC) of anti-HTR2A antibody
Immunofluorescent analysis of PC3 cells using MBS1495072 at a dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
anti-HTR2A antibody Immunohistochemistry (IHC) (IHC) image
NCBI/Uniprot data below describe general gene information for HTR2A. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
43,940 Da
NCBI Official Full Name
5-hydroxytryptamine receptor 2A isoform 1
NCBI Official Synonym Full Names
5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled
NCBI Official Symbol
HTR2A  [Similar Products]
NCBI Official Synonym Symbols
HTR2; 5-HT2A
  [Similar Products]
NCBI Protein Information
5-hydroxytryptamine receptor 2A
UniProt Protein Name
5-hydroxytryptamine receptor 2A
UniProt Synonym Protein Names
Serotonin receptor 2A
UniProt Gene Name
HTR2A  [Similar Products]
UniProt Synonym Gene Names
HTR2; 5-HT-2; 5-HT-2A  [Similar Products]
UniProt Entry Name
5HT2A_HUMAN
NCBI Summary for HTR2A
This gene encodes one of the receptors for serotonin, a neurotransmitter with many roles. Mutations in this gene are associated with susceptibility to schizophrenia and obsessive-compulsive disorder, and are also associated with response to the antidepressant citalopram in patients with major depressive disorder (MDD). MDD patients who also have a mutation in intron 2 of this gene show a significantly reduced response to citalopram as this antidepressant downregulates expression of this gene. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]
UniProt Comments for HTR2A
5-HT(2A): This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. This receptor is involved in tracheal smooth muscle contraction, bronchoconstriction, and control of aldosterone production. Belongs to the G-protein coupled receptor 1 family.

Protein type: Membrane protein, integral; Membrane protein, multi-pass; GPCR, family 1; Receptor, GPCR

Chromosomal Location of Human Ortholog: 13q14-q21

Cellular Component: axon; caveola; cell soma; cytoplasmic membrane-bound vesicle; cytosol; dendritic shaft; integral to plasma membrane; plasma membrane

Molecular Function: drug binding; G-protein alpha-subunit binding; protein complex binding; serotonin binding; serotonin receptor activity; viral receptor activity

Biological Process: aging; artery smooth muscle contraction; behavioral response to cocaine; cell death; cellular calcium ion homeostasis; detection of mechanical stimulus involved in sensory perception of pain; detection of temperature stimulus involved in sensory perception of pain; entry of virus into host cell; memory; negative regulation of potassium ion transport; negative regulation of synaptic transmission, glutamatergic; phosphoinositide 3-kinase cascade; phospholipase C activation; positive regulation of cell proliferation; positive regulation of fat cell differentiation; positive regulation of glycolysis; positive regulation of MAP kinase activity; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of phosphatidylinositol biosynthetic process; positive regulation of vasoconstriction; regulation of behavior; regulation of dopamine secretion; regulation of hormone secretion; release of sequestered calcium ion into cytosol; response to drug; serotonin receptor signaling pathway; serotonin receptor, phospholipase C activating pathway; sleep; synaptic transmission; thermoregulation; urinary bladder smooth muscle contraction

Disease: Alcohol Dependence; Anorexia Nervosa, Susceptibility To, 1; Major Depressive Disorder; Obsessive-compulsive Disorder; Schizophrenia
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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