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anti-HIP1 antibody :: Rabbit anti-Human Huntingtin-interacting protein 1 Polyclonal Antibody

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Catalog # MBS1493805
Unit / Price
  0.05 mL  /  $120 +1 FREE 8GB USB
  0.1 mL  /  $160 +1 FREE 8GB USB
Product Name

Huntingtin-interacting protein 1 (HIP1), Polyclonal Antibody

Popular Item
Also Known As

Rabbit anti-human Huntingtin-interacting protein 1 polyclonal Antibody(HIP1)

Product Synonym Names
HIP-1; Huntingtin-interacting protein I; HIP-I
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Length
986
OMIM
601767
3D Structure
ModBase 3D Structure for O00291
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Purity/Purification
Antigen Affinity Purified
Storage Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Conjugate
Non-conjugated
Immunogen
Recombinant human Huntingtin-interacting protein 1 protein(410-690aa)
Santa Cruz Alternative
Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-20897 / sc-20899 / sc-33601
Preparation and Storage
Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Other Notes
Small volumes of anti-HIP1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-HIP1 antibody
Plays a role in clathrin-mediated endocytosis and trafficking. Involved in regulating AMPA receptor trafficking in the central nervous system in an NMDA-dependent manner. Enhances androgen receptor (AR)-mediated transcription. May act as a proapoptotic protein that induces cell death by acting through the intrinsic apoptosis pathway. Binds 3-phosphoinositides (via ENTH domain). May act through the ENTH domain to promote cell survival by stabilizing receptor tyrosine kinases following ligand-induced endocytosis. May play a functional role in the cell filament networks. May be required for differentiation, proliferation, and/or survival of somatic and germline progenitors.
Applications Tested/Suitable for anti-HIP1 antibody
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-HIP1 antibody
Recommended dilution: WB:1:200-1000
IHC:1:20-1:200

Western Blot (WB) of anti-HIP1 antibody
Western blot
All lanes: HIP1 antibody at 4ug/ml+A549 whole cell lysate
Secondary
Goat polyclonal to rabbit at 1/10000 dilution
Predicted band size: 117,111,114 kDa
Observed band size: 116 kDa

anti-HIP1 antibody Western Blot (WB) (WB) image
Immunohistochemistry (IHC) of anti-HIP1 antibody
Immunohistochemistry of paraffin-embedded human colorectal carcinoma using MBS1493805 at dilution 1:100
anti-HIP1 antibody Immunohistochemistry (IHC) (IHC) image
Immunohistochemistry (IHC) of anti-HIP1 antibody
Immunohistochemistry of paraffin-embedded human placenta using MBS1493805 at dilution 1:100
anti-HIP1 antibody Immunohistochemistry (IHC) (IHC) image
NCBI/Uniprot data below describe general gene information for HIP1. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
113,076 Da
NCBI Official Full Name
huntingtin-interacting protein 1 isoform 2
NCBI Official Synonym Full Names
huntingtin interacting protein 1
NCBI Official Symbol
NCBI Official Synonym Symbols
SHON; HIP-I; ILWEQ; SHONbeta; SHONgamma
  [Similar Products]
NCBI Protein Information
huntingtin-interacting protein 1
UniProt Protein Name
Huntingtin-interacting protein 1
UniProt Synonym Protein Names
Huntingtin-interacting protein I; HIP-I
Protein Family
UniProt Gene Name
UniProt Synonym Gene Names
HIP-1; HIP-I  [Similar Products]
UniProt Entry Name
HIP1_HUMAN
NCBI Summary for HIP1
The product of this gene is a membrane-associated protein that functions in clathrin-mediated endocytosis and protein trafficking within the cell. The encoded protein binds to the huntingtin protein in the brain; this interaction is lost in Huntington's disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
UniProt Comments for HIP1
HIP1: Plays a role in clathrin-mediated endocytosis and trafficking. Involved in regulating AMPA receptor trafficking in the central nervous system in an NMDA-dependent manner. Enhances androgen receptor (AR)-mediated transcription. May act as a proapoptotic protein that induces cell death by acting through the intrinsic apoptosis pathway. Binds 3-phosphoinositides (via ENTH domain). May act through the ENTH domain to promote cell survival by stabilizing receptor tyrosine kinases following ligand-induced endocytosis. May play a functional role in the cell filament networks. May be required for differentiation, proliferation, and/or survival of somatic and germline progenitors. A chromosomal aberration involving HIP1 is found in a form of chronic myelomonocytic leukemia (CMML). Translocation t(5;7)(q33;q11.2) with PDGFRB. The chimeric HIP1-PDGFRB transcript results from an in-frame fusion of the two genes. The reciprocal PDGFRB-HIP1 transcript is not expressed. Belongs to the SLA2 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Apoptosis; Cytoskeletal

Chromosomal Location of Human Ortholog: 7q11.23

Cellular Component: clathrin coated vesicle membrane; clathrin-coated vesicle; cytoplasm; cytoskeleton; Golgi apparatus; intracellular membrane-bound organelle; membrane; nucleus

Molecular Function: actin binding; clathrin binding; phosphoinositide binding; protein binding; structural constituent of cytoskeleton

Biological Process: apoptosis; caspase activation; cell differentiation; clathrin cage assembly; positive regulation of receptor-mediated endocytosis; regulation of apoptosis; regulation of transcription, DNA-dependent; transcription, DNA-dependent

Disease: Prostate Cancer
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

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