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anti-IGF1 antibody :: Rabbit anti-Human IGF1 IGF1 Polyclonal Antibody

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Catalog # MBS535810
Unit / Price
  0.05 mg  /  $310 +1 FREE 8GB USB
anti-IGF1 antibody
Product Name

IGF1, Polyclonal Antibody

Full Product Name

IGF1 antibody

Product Synonym Names
Polyclonal IGF1; Anti-IGF1; IGF-1; IGF 1; IGF1; Somatamedin C; Insulin-like Growth Factor-I; IGF-IA
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q76BR7
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human IGF1
Form/Format
Lyophilized from PBS, pH 7.2.
Biological Significance
The IGFs are mitogenic polypeptide growth factors that stimulate the proliferation and survival of various cell types including muscle, bone, and cartilage tissue in vitro. IGFs are predominantly produced by the liver, although a variety of tissues produce the IGFs at distinctive times. The IGFs belong to the Insulin gene family, which also contains insulin and relaxin. The IGFs are similar by structure and function to insulin, but have a much higher growth-promoting activity than insulin. IGF-II expression is influenced by placenta lactogen, while IGF-I expression is regulated by growth hormone. Both IGF-I and IGF-II signal through the tyrosine kinase type I receptor (IGF-IR), but, IGF-II can also signal through the IGF-II/Mannose-6-phosphate receptor. Mature IGFs are generated by proteolytic processing of inactive precursor proteins, which contain N-terminal and C-terminal propeptide regions.
Immunogen
IGF1 antibody was raised in rabbit using highly pure recombinant human IGF-I as the immunogen.
Preparation and Storage
Store at -20 degree C until reconstitution. Following reconstitution product may be stored at 4 degree C in the short term. For long term storage aliquot and freeze at -20 degree C. Avoid repeated freeze/thaw cycles.
Other Notes
Small volumes of anti-IGF1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-IGF1 antibody
Affinity purified Rabbit polyclonal IGF1 antibody
Applications Tested/Suitable for anti-IGF1 antibody
ELISA (EIA), Inhibition, Western Blot (WB)
Application Notes for anti-IGF1 antibody
ELISA: 0.5-2 ug/ml
Inhibition: 0.67-0.1 ug/ml
WB: 0.1-0.2 ug/ml
NCBI/Uniprot data below describe general gene information for IGF1. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Related Accession #
Molecular Weight
7.6 kDa (predicted detection band MW)
NCBI Official Full Name
I-309, partial
NCBI Official Synonym Full Names
chemokine (C-C motif) ligand 1
NCBI Official Symbol
NCBI Official Synonym Symbols
P500; SISe; TCA3; I-309; SCYA1
  [Similar Products]
NCBI Protein Information
C-C motif chemokine 1
UniProt Protein Name
I-309
UniProt Synonym Protein Names
I-309
UniProt Gene Name
SCYA1  [Similar Products]
UniProt Entry Name
Q76BR7_HUMAN
NCBI Summary for IGF1
This antimicrobial gene is one of several chemokine genes clustered on the q-arm of chromosome 17. Chemokines form a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of the N-terminal cysteine residues of the mature peptide. This chemokine, a member of the CC subfamily, is secreted by activated T cells and displays chemotactic activity for monocytes but not for neutrophils. It binds to the chemokine (C-C motif) receptor 8. [provided by RefSeq, Sep 2014]
UniProt Comments for IGF1
CCL1: Cytokine that is chemotactic for monocytes but not for neutrophils. Binds to CCR8. Belongs to the intercrine beta (chemokine CC) family.

Protein type: Chemokine; Secreted, signal peptide; Secreted; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 17q12

Cellular Component: extracellular space

Molecular Function: chemokine activity

Biological Process: cellular calcium ion homeostasis; viral reproduction; immune response; chemotaxis; signal transduction
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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