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anti-IL17 antibody :: Rabbit IL17 Polyclonal Antibody

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Catalog # MBS535878
Unit / Price
  0.05 mg  /  $310 +1 FREE 8GB USB
anti-IL17 antibody
Product Name

IL17, Polyclonal Antibody

Popular Item
Also Known As

IL17 antibody

Product Synonym Names
Polyclonal IL17; Anti-IL17; IL-17; CTLA-8; IL17; IL 17; Interleukin 17
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Length
155
OMIM
603149
3D Structure
ModBase 3D Structure for Q16552
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
To be determined by end user.
Form/Format
Sterile filtered and lyophilized form PBS, pH 7.2. Reconstitute with sterile water to 0.1-1.0mg/ml. Centrifuge vial prior to opening.
Biological Significance
The originally described IL17 protein, now known as IL17A, is a homodimer of two 136 amino acid chains, secreted by activated T-cells that act on stromal cells to induce production of proinflammatory and hematopoietic bioactive molecules. Today, IL17 represents a family of structurally-related cytokines that share a highly conserved C-terminal region but differ from one another in their N-terminal regions and in their distinct biological roles. The six known members of this family, IL17A through IL17F, are secreted as homodimers. IL17A exhibits cross-species bioactivity between human and Mouse cells.
Immunogen
E.coli-derived, 31.3kDa Recombinant Human IL-17A
Preparation and Storage
Ships ambient or refrigerated. Upon receipt store at 4°C for short term, -20°C for long term.
Other Notes
Small volumes of anti-IL17 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-IL17 antibody
Affinity purified Rabbit polyclonal IL17 antibody
Applications Tested/Suitable for anti-IL17 antibody
Immunostaining, Neutralization, Sandwich ELISA, Western Blot.
Application Notes for anti-IL17 antibody
ELISA: 0.5-2 ug/ml
Inhibition: 0.9-1.3 ug/ml
WB: 0.1-0.2 ug/ml
NCBI/Uniprot data below describe general gene information for IL17. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
31.0 kDa (predicted detection band MW)
NCBI Official Full Name
interleukin-17A
NCBI Official Synonym Full Names
interleukin 17A
NCBI Official Symbol
IL17A  [Similar Products]
NCBI Official Synonym Symbols
IL17; CTLA8; IL-17; IL-17A
  [Similar Products]
NCBI Protein Information
interleukin-17A
UniProt Protein Name
Interleukin-17A
UniProt Synonym Protein Names
Cytotoxic T-lymphocyte-associated antigen 8; CTLA-8
UniProt Gene Name
IL17A  [Similar Products]
UniProt Synonym Gene Names
CTLA8; IL17; IL-17; IL-17A; CTLA-8  [Similar Products]
UniProt Entry Name
IL17_HUMAN
NCBI Summary for IL17
The protein encoded by this gene is a proinflammatory cytokine produced by activated T cells. This cytokine regulates the activities of NF-kappaB and mitogen-activated protein kinases. This cytokine can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). High levels of this cytokine are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis. [provided by RefSeq, Jul 2008]
UniProt Comments for IL17
IL17A: Induces stromal cells to produce proinflammatory and hematopoietic cytokines. Enhances the surface expression of ICAM1/intracellular adhesion molecule 1 in fibroblasts. Belongs to the IL-17 family.

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 6p12

Cellular Component: extracellular space; external side of plasma membrane

Molecular Function: cytokine activity

Biological Process: cell death; cell-cell signaling; apoptosis; positive regulation of osteoclast differentiation; positive regulation of interleukin-23 production; protein amino acid glycosylation; immune response; positive regulation of transcription from RNA polymerase II promoter; inflammatory response
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Organs/Tissues associated with anti-IL17 antibody
 Organ/Tissue Name  Pubmed Publications
 Mixed Antibodies  >113 publications with IL17 and Mixed
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