NP_000409.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
Calculated MW: 89658
NCBI Official Full Name
interleukin-4 receptor subunit alpha isoform a
NCBI Official Synonym Full Names
interleukin 4 receptor
NCBI Protein Information
interleukin-4 receptor subunit alpha
UniProt Protein Name
Interleukin-4 receptor subunit alpha
UniProt Synonym Protein Names
CD_antigen: CD124
UniProt Synonym Gene Names
IL4RA; IL-4 receptor subunit alpha; IL-4R subunit alpha; IL-4R-alpha; IL-4RA; Soluble IL-4 receptor subunit alpha; Soluble IL-4R-alpha; sIL4Ralpha/prot; IL4-BP [Similar Products]
UniProt Entry Name
IL4RA_HUMAN
NCBI Summary for IL4R
This gene encodes the alpha chain of the interleukin-4 receptor, a type I transmembrane protein that can bind interleukin 4 and interleukin 13 to regulate IgE production. The encoded protein also can bind interleukin 4 to promote differentiation of Th2 cells. A soluble form of the encoded protein can be produced by proteolysis of the membrane-bound protein, and this soluble form can inhibit IL4-mediated cell proliferation and IL5 upregulation by T-cells. Allelic variations in this gene have been associated with atopy, a condition that can manifest itself as allergic rhinitis, sinusitus, asthma, or eczema. Polymorphisms in this gene are also associated with resistance to human immunodeficiency virus type-1 infection. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Apr 2012]
UniProt Comments for IL4R
IL4R: Receptor for both interleukin 4 and interleukin 13. Couples to the JAK1/2/3-STAT6 pathway. The IL4 response is involved in promoting Th2 differentiation. The IL4/IL13 responses are involved in regulating IgE production and, chemokine and mucus production at sites of allergic inflammation. In certain cell types, can signal through activation of insulin receptor substrates, IRS1/IRS2. Belongs to the type I cytokine receptor family. Type 4 subfamily. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, integral; Receptor, cytokine
Chromosomal Location of Human Ortholog: 16p12.1-p11.2
Cellular Component: extracellular space; integral to plasma membrane; receptor complex
Molecular Function: protein binding; interleukin-4 receptor activity; receptor signaling protein activity
Biological Process: ovulation; positive regulation of T-helper 2 cell differentiation; negative regulation of T-helper 1 cell differentiation; production of molecular mediator of acute inflammatory response; response to estrogen stimulus; immune response; defense response to protozoan; signal transduction; regulation of cell proliferation; positive regulation of macrophage activation
Disease: Ige Responsiveness, Atopic; Human Immunodeficiency Virus Type 1, Susceptibility To
Product References and Citations for anti-IL4R antibody
Idzerda R.L.,et al.J. Exp. Med. 171:861-873(1990). Galizzi J.-P.,et al.Int. Immunol. 2:669-675(1990). Kruse S.,et al.Int. Immunol. 11:1965-1970(1999). Loftus B.J.,et al.Genomics 60:295-308(1999). Ota T.,et al.Nat. Genet. 36:40-45(2004).
Research Articles on IL4R
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Products associated with anti-IL4R antibody
Diseases associated with anti-IL4R antibody
Organs/Tissues associated with anti-IL4R antibody
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