NP_005529.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
38,238 Da
NCBI Official Full Name
inhibin beta C chain preproprotein
NCBI Official Synonym Full Names
inhibin beta C subunit
NCBI Official Synonym Symbols
NCBI Protein Information
inhibin beta C chain
UniProt Protein Name
Inhibin beta C chain
UniProt Synonym Protein Names
Activin beta-C chain
UniProt Entry Name
INHBC_HUMAN
NCBI Summary for INHBC
This gene encodes a member of the TGF-beta (transforming growth factor-beta) superfamily of proteins. The encoded preproprotein is proteolytically processed to generate a subunit of homodimeric and heterodimeric activin complexes. The heterodimeric complex may function in the inhibition of activin A signaling. Transgenic mice overexpressing this gene exhibit defects in testis, liver and prostate. [provided by RefSeq, Aug 2016]
UniProt Comments for INHBC
INHBC: Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins. Belongs to the TGF-beta family.
Protein type: Secreted, signal peptide; Secreted
Chromosomal Location of Human Ortholog: 12q13.1
Cellular Component: extracellular region; extracellular space
Molecular Function: cytokine activity; transforming growth factor beta receptor binding
Biological Process: cell development; regulation of apoptosis; regulation of MAPKKK cascade
Research Articles on INHBC
Precautions
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Pathways associated with anti-INHBC antibody
Diseases associated with anti-INHBC antibody
Organs/Tissues associated with anti-INHBC antibody
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