NP_001182215.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
51,644 Da
NCBI Official Full Name
interferon regulatory factor 4 isoform 2
NCBI Official Synonym Full Names
interferon regulatory factor 4
NCBI Protein Information
interferon regulatory factor 4
UniProt Protein Name
Interferon regulatory factor 4
UniProt Synonym Protein Names
Lymphocyte-specific interferon regulatory factor; LSIRF; Multiple myeloma oncogene 1; NF-EM5
UniProt Synonym Gene Names
UniProt Entry Name
IRF4_HUMAN
NCBI Summary for IRF4
The protein encoded by this gene belongs to the IRF (interferon regulatory factor) family of transcription factors, characterized by an unique tryptophan pentad repeat DNA-binding domain. The IRFs are important in the regulation of interferons in response to infection by virus, and in the regulation of interferon-inducible genes. This family member is lymphocyte specific and negatively regulates Toll-like-receptor (TLR) signaling that is central to the activation of innate and adaptive immune systems. A chromosomal translocation involving this gene and the IgH locus, t(6;14)(p25;q32), may be a cause of multiple myeloma. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Aug 2010]
UniProt Comments for IRF4
IRF4: Transcriptional activator. Binds to the interferon- stimulated response element (ISRE) of the MHC class I promoter. Binds the immunoglobulin lambda light chain enhancer, together with PU.1. Probably plays a role in ISRE-targeted signal transduction mechanisms specific to lymphoid cells. Interacts with SPIB and DEF6. Not induced by interferons. Lymphoid cells. Belongs to the IRF family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: DNA-binding; Transcription factor; Oncoprotein
Chromosomal Location of Human Ortholog: 6p25-p23
Cellular Component: cytoplasm; cytosol; membrane; nucleoplasm; nucleus
Molecular Function: protein binding; protein-lysine N-methyltransferase activity; sequence-specific DNA binding; transcription factor activity; transcription factor binding
Biological Process: cytokine and chemokine mediated signaling pathway; defense response to protozoan; myeloid dendritic cell differentiation; negative regulation of toll-like receptor signaling pathway; peptidyl-lysine methylation; positive regulation of DNA binding; positive regulation of interleukin-10 biosynthetic process; positive regulation of interleukin-13 biosynthetic process; positive regulation of interleukin-2 biosynthetic process; positive regulation of interleukin-4 biosynthetic process; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; regulation of T-helper cell differentiation; T cell activation; transcription from RNA polymerase II promoter
Disease: Skin/hair/eye Pigmentation, Variation In, 8
Research Articles on IRF4
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Products associated with anti-IRF4 antibody
Pathways associated with anti-IRF4 antibody
Diseases associated with anti-IRF4 antibody
Disease Name |
Pubmed Publications |
Multiple Myeloma Antibodies |
>74 publications with IRF4 and Multiple Myeloma |
Inflammation Antibodies |
>62 publications with IRF4 and Inflammation |
Skin Neoplasms Antibodies |
>31 publications with IRF4 and Skin Neoplasms |
Disease Models, Animal Antibodies |
>27 publications with IRF4 and Disease Models, Animal |
Leukemia, Lymphocytic, Chronic, B-Cell Antibodies |
>23 publications with IRF4 and Leukemia, Lymphocytic, Chronic, B-Cell |
Necrosis Antibodies |
>18 publications with IRF4 and Necrosis |
Lung Diseases Antibodies |
>17 publications with IRF4 and Lung Diseases |
Cell Transformation, Neoplastic Antibodies |
>16 publications with IRF4 and Cell Transformation, Neoplastic |
Lymphoma, T-Cell, Cutaneous Antibodies |
>12 publications with IRF4 and Lymphoma, T-Cell, Cutaneous |
Hyperplasia Antibodies |
>8 publications with IRF4 and Hyperplasia |
Organs/Tissues associated with anti-IRF4 antibody
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