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anti-IL1R1 antibody :: Rabbit anti-Human Interleukin 1 Receptor Type I (IL1R1) Polyclonal Antibody

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Catalog # MBS2005592 (SPECIAL PROMOTION: Get FREE $5 Starbucks gift card (Maximum 5 gift cards/product). Gift card(s) will be included with shipment)
Unit / Price
  0.01 mg  /  $105 +1 FREE 8GB USB
  0.02 mg  /  $125 +1 FREE 8GB USB
  0.05 mg  /  $165 +1 FREE 8GB USB
  0.1 mg  /  $210 +1 FREE 8GB USB
  0.2 mg  /  $310 +1 FREE 8GB USB
  1 mg  /  $725 +1 FREE 8GB USB
Product Name

Interleukin 1 Receptor Type I (IL1R1), Polyclonal Antibody

Popular Item
Full Product Name

Polyclonal Antibody to Interleukin 1 Receptor Type I (IL1R1)

Matching Pairs
Matching Pairs
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence
Antigen: The target protein is fused with N-terminal His-Tag and its sequence is listed below.
MGHHHHHHSG SEF-DKCKER EEKI ILVSSANEID VRPCPLNPNE HKGTITWYKD DSKTPVSTEQ ASRIHQHKEK LWFVPAKVED SGHYYCVVRN SSYCLRIKI
OMIM
X16896 mRNA
3D Structure
ModBase 3D Structure for P14778
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Specificity
The antibody is a rabbit polyclonal antibody raised against IL1R1. It has been selected for its ability to recognize IL1R1 in immunohistochemical staining andwestern blotting.
Purity/Purification
Affinity Chromatography
Form/Format
Supplied as solution form in PBS, pH7.4, containing 0.02% NaN3,50% glycerol.
Concentration
200ug/ml (lot specific)
Immunogen
Recombinant IL1R1 (Asp21~Ile109) expressed in E.coli.
Conjugated Antibody
The APC conjugated antibody version of this item is also available as catalog #MBS2036593
Preparation and Storage
Store at 4 degree C for frequent use. Stored at -20 degree C to -80 degree C in a manual defrost freezer for one year without detectable loss of activity. Avoid repeated freeze-thaw cycles.
ISO Certification
Manufactured in an ISO 9001:2008 and ISO 13485:2003 Certified Laboratory.
Supply Chain Verification
Manufactured in a lab with traceable raw materials. Bulk orders can typically be prepared to the customer’s specifications, please inquire.
Other Notes
Small volumes of anti-IL1R1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Product Categories/Family for anti-IL1R1 antibody
Applications Tested/Suitable for anti-IL1R1 antibody
Immunocytochemistry (ICC), Immunohistochemistry (IHC) - Formalin/Paraffin, ELISA (EIA), Western Blot (WB)
Application Notes for anti-IL1R1 antibody
Western blotting: 1:100-400
Immunocytochemistry in formalin fixed cells: 1:100-500
Immunohistochemistry in formalin fixed frozen section: 1:100-500
Immunohistochemistry in paraffin section: 1:50-200
Enzyme-linked Immunosorbent Assay: 1:100-200

Western Blot (WB) of anti-IL1R1 antibody
Western Blot: Sample: Human Raji Cells.
anti-IL1R1 antibody Western Blot (WB) (WB) image
Western Blot (WB) of anti-IL1R1 antibody
Western Blot: Sample: Recombinant IL1R1, Human.
anti-IL1R1 antibody Western Blot (WB) (WB) image
Immunohistochemistry (IHC) of anti-IL1R1 antibody
DAB staining on IHC-P; Samples: Human Liver Tissue.
anti-IL1R1 antibody Immunohistochemistry (IHC) (IHC) image
Immunohistochemistry (IHC) of anti-IL1R1 antibody
DAB staining on IHC-P; Samples: Human Stomach Tissue
anti-IL1R1 antibody Immunohistochemistry (IHC) (IHC) image
Immunohistochemistry (IHC) of anti-IL1R1 antibody
DAB staining on IHC-P; Samples: Human Thyroid Cancer Tissue
anti-IL1R1 antibody Immunohistochemistry (IHC) (IHC) image
Knockout Validation of anti-IL1R1 antibody
Knockout Validation: Lane 1: Wild-type Raji cell lysate; Lane 2: IL1R1 knockout Raji cell lysate; Predicted MW: 65kd Observed MW: 65kd Primary Ab: 3ug/ml Rabbit Anti-Human IL1R1 Antibody Second Ab: 0.2ug/mL HRP-Linked Caprine Anti-Rabbit IgG Polyclonal Antibody (#MBS2086047)
anti-IL1R1 antibody Knockout Validation image
NCBI/Uniprot data below describe general gene information for IL1R1. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
65,402 Da
NCBI Official Full Name
interleukin-1 receptor type 1 isoform 1
NCBI Official Synonym Full Names
interleukin 1 receptor type 1
NCBI Official Symbol
IL1R1  [Similar Products]
NCBI Official Synonym Symbols
P80; IL1R; IL1RA; CD121A; D2S1473; IL-1R-alpha
  [Similar Products]
NCBI Protein Information
interleukin-1 receptor type 1
UniProt Protein Name
Interleukin-1 receptor type 1
UniProt Synonym Protein Names
CD121 antigen-like family member A; Interleukin-1 receptor alpha; IL-1R-alpha
Protein Family
UniProt Gene Name
IL1R1  [Similar Products]
UniProt Synonym Gene Names
IL1R; IL1RA; IL1RT1; IL-1R-1; IL-1RT-1; IL-1RT1; IL-1R-alpha; mIL-1R1; mIL-1RI; sIL-1R1; sIL-1RI  [Similar Products]
NCBI Summary for IL1R1
This gene encodes a cytokine receptor that belongs to the interleukin-1 receptor family. The encoded protein is a receptor for interleukin-1 alpha, interleukin-1 beta, and interleukin-1 receptor antagonist. It is an important mediator involved in many cytokine-induced immune and inflammatory responses. This gene is located in a cluster of related cytokine receptor genes on chromosome 2q12. [provided by RefSeq, Dec 2013]
UniProt Comments for IL1R1
IL-1RA: Receptor for IL1A, IL1B and IL1RN. After binding to interleukin-1 associates with the corecptor IL1RAP to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B, MAPK and other pathways. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. Binds ligands with comparable affinity and binding of antagonist IL1RN prevents association with IL1RAP to form a signaling complex. Belongs to the interleukin-1 receptor family.

Protein type: EC 2.7.11.25; Membrane protein, integral; Receptor, cytokine

Chromosomal Location of Human Ortholog: 2q11.2-q12.1

Cellular Component: external side of plasma membrane; extracellular region; integral component of plasma membrane; intracellular membrane-bound organelle; membrane; plasma membrane

Molecular Function: interleukin-1 binding; interleukin-1 receptor activity; interleukin-1, Type I, activating receptor activity; platelet-derived growth factor receptor binding; protease binding; protein binding; signal transducer activity; transmembrane receptor activity

Biological Process: cell surface receptor signaling pathway; immune response; positive regulation of interleukin-1-mediated signaling pathway; positive regulation of neutrophil extravasation; regulation of inflammatory response
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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