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anti-INVS antibody :: Rabbit anti-Human INVS Polyclonal Antibody

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Catalog # MBS7044719
Unit / Price
  0.05 mg  /  $160 +1 FREE 8GB USB
  0.1 mg  /  $235 +1 FREE 8GB USB
Product Name

INVS, Polyclonal Antibody

Popular Item
Also Known As

INVS Antibody

Product Synonym Names
Inversin; Inversion of embryo turning homolog; Nephrocystin-2; INVS; INV; NPHP2
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Length
1065
OMIM
243305
3D Structure
ModBase 3D Structure for Q9Y283
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Purity/Purification
>95%, Protein G purified
Form/Format
Liquid
Species
Human
Immunogen
Recombinant human Inversin protein
Conjugate
Non-conjugated
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Santa Cruz Alternative
Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-8719 / sc-12550
Preparation and Storage
Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Other Notes
Small volumes of anti-INVS antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-INVS antibody
Required for normal renal development and establishment of left-right axis. Probably acts as a molecular switch between different Wnt signaling pathways. Inhibits the canonical Wnt pathway by targeting cytoplasmic disheveled (DVL1) for degradation by the ubiquitin-proteasome. This suggests that it is required in renal development to oppose the repression of terminal differentiation of tubular epithelial cells by Wnt signaling. Involved in the organization of apical junctions in kidney cells together with NPHP1, NPHP4 and RPGRIP1L/NPHP8 (By similarity). Does not seem to be strictly required for ciliogenesis (By similarity).
Applications Tested/Suitable for anti-INVS antibody
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Western Blot (WB) of anti-INVS antibody
Western blot
All lanes: INVS antibody IgG at 14ug/ml+ K562 whole cell lysate
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 118,100,11 kDa
Observed band size: 118 kDa

anti-INVS antibody Western Blot (WB) (WB) image
Immunohistochemistry (IHC) of anti-INVS antibody
Immunohistochemistry of paraffin-embedded human liver cancer using MBS7044719 at dilution 1:100
anti-INVS antibody Immunohistochemistry (IHC) (IHC) image
Immunohistochemistry (IHC) of anti-INVS antibody
Immunofluorescent analysis of HepG-2 cells using MBS7044719 at a dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
anti-INVS antibody Immunohistochemistry (IHC) (IHC) image
NCBI/Uniprot data below describe general gene information for INVS. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
10,748 Da
NCBI Official Full Name
inversin isoform a
NCBI Official Synonym Full Names
inversin
NCBI Official Symbol
NCBI Official Synonym Symbols
INV; NPH2; NPHP2
  [Similar Products]
NCBI Protein Information
inversin
UniProt Protein Name
Inversin
UniProt Synonym Protein Names
Inversion of embryo turning homolog; Nephrocystin-2
Protein Family
UniProt Gene Name
UniProt Synonym Gene Names
INV; NPHP2  [Similar Products]
UniProt Entry Name
INVS_HUMAN
NCBI Summary for INVS
This gene encodes a protein containing multiple ankyrin domains and two IQ calmodulin-binding domains. The encoded protein may function in renal tubular development and function, and in left-right axis determination. This protein interacts with nephrocystin and infers a connection between primary cilia function and left-right axis determination. A similar protein in mice interacts with calmodulin. Mutations in this gene have been associated with nephronophthisis type 2. Multiple transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, May 2012]
UniProt Comments for INVS
INVS: Required for normal renal development and establishment of left-right axis. Probably acts as a molecular switch between different Wnt signaling pathways. Inhibits the canonical Wnt pathway by targeting cytoplasmic disheveled (DVL1) for degradation by the ubiquitin-proteasome. This suggests that it is required in renal development to oppose the repression of terminal differentiation of tubular epithelial cells by Wnt signaling. Involved in the organization of apical junctions in kidney cells together with NPHP1, NPHP4 and RPGRIP1L/NPHP8. Does not seem to be strictly required for ciliogenesis. Defects in INVS are the cause of nephronophthisis type 2 (NPHP2); also known as infantile nephronophthisis. NPHP2 is an autosomal recessive disorder resulting in end-stage renal disease. It is characterized by early onset and rapid progression. Phenotypic manifestations include enlarged kidneys, chronic tubulo-interstitial nephritis, anemia, hyperkalemic metabolic acidosis. Some patients also display situs inversus. Pathologically, it differs from later-onset nephronophthisis by the absence of medullary cysts and thickened tubular basement membranes and by the presence of cortical microcysts. 3 isoforms of the human protein are produced by alternative splicing.

Chromosomal Location of Human Ortholog: 9q31

Molecular Function: protein binding

Disease: Nephronophthisis 2
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

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Pathways associated with anti-INVS antibody
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