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anti-KLK1 antibody :: Rabbit anti-Human Kallikrein 1 Polyclonal Antibody

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Catalog # MBS175239
Unit / Price
  0.1 mg  /  $315 +1 FREE 8GB USB
Product Name

Kallikrein 1 (KLK1), Polyclonal Antibody

Popular Item
Also Known As

Anti-Kallikrein 1 antibody

Product Synonym Names
Kallikrein-1; kallikrein 1; Glandular kallikrein 1 antibody; hK 1 antibody; hK1 antibody; Kallikrein serine protease 1 antibody; Kallikrein-1 antibody; Kidney/pancreas/salivary gland kallikrein antibody; Klk 6 antibody; KLK1 antibody; KLK1_HUMAN antibody; Klk6 antibody; KLKR antibody; Tissue kallikrein antibody
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Length
262
OMIM
147910
3D Structure
ModBase 3D Structure for P06870
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Purity/Purification
Immunogen affinity purified.
Form/Format
Lyophilized
Immunogen
A synthetic peptide corresponding to a sequence in the middle region of human Kallikrein 1 (182-197aa NDECKKAHVQKVTDFM).
Contents
Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.
Reconstitution
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Preparation and Storage
At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time. Avoid repeated freezing and thawing.
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Other Notes
Small volumes of anti-KLK1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-KLK1 antibody
Description: Rabbit IgG polyclonal antibody for Kallikrein-1(KLK1) detection. Tested with WB, IHC-P in Human.
Background: KLK1(KALLIKREIN 1), also called KLKR, is a protein that in humans is encoded by the KLK1 gene. KLK1 is a member of the peptidase S1 family. KLK1 is a serine protease that generates Lys-bradykinin by specific proteolysis of kininogen-1. The KLK1 gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19 and its exact cytogenetic location is 19q13.33. The KLK1 gene contains 5 coding exons. And KLK1 is the most centromeric gene in the cluster. Mice lacking tissue kallikrein are unable to generate significant levels of kinins in most tissues and develop cardiovascular abnormalities early in adulthood despite normal blood pressure. The protein is functionally conserved in its capacity to release the vasoactive peptide, Lys-bradykinin, from low molecular weight kininogen.
Applications Tested/Suitable for anti-KLK1 antibody
Western Blot (WB), Immunohistochemistry (IHC) Paraffin
Application Notes for anti-KLK1 antibody
WB: 0.1-0.5ug/ml (Species: Human)
IHC-P: 0.5-1ug/ml (Species: Human) (Antigen Retrieval: By Heat)

Western Blot (WB) of anti-KLK1 antibody
Anti-Kallikrein 1 antibody, MBS175239, Western blotting
Lane 1: Recombinant Human KLK1 Protein 10ng
Lane 2: Recombinant Human KLK1 Protein 5ng
Lane 3: Recombinant Human KLK1 Protein 2.5ng
anti-KLK1 antibody Western Blot (WB) (WB) image
Immunohistochemistry (IHC) of anti-KLK1 antibody
Anti-Kallikrein 1 antibody, MBS175239, IHC(P)
IHC(P): Human Pancreatic Cancer Tissue
anti-KLK1 antibody Immunohistochemistry (IHC) (IHC) image
NCBI/Uniprot data below describe general gene information for KLK1. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
23,835 Da
NCBI Official Full Name
Kallikrein-1
NCBI Official Synonym Full Names
kallikrein 1
NCBI Official Symbol
NCBI Official Synonym Symbols
hK1; KLKR; Klk6
  [Similar Products]
NCBI Protein Information
kallikrein-1; tissue kallikrein; glandular kallikrein 1; kallikrein serine protease 1; kallikrein 1, renal/pancreas/salivary; kidney/pancreas/salivary gland kallikrein
UniProt Protein Name
Kallikrein-1
UniProt Synonym Protein Names
Kidney/pancreas/salivary gland kallikrein; Tissue kallikrein
UniProt Gene Name
UniProt Entry Name
KLK1_HUMAN
NCBI Summary for KLK1
Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. This protein is functionally conserved in its capacity to release the vasoactive peptide, Lys-bradykinin, from low molecular weight kininogen. [provided by RefSeq, Jul 2008]
UniProt Comments for KLK1
KLK1: Glandular kallikreins cleave Met-Lys and Arg-Ser bonds in kininogen to release Lys-bradykinin. Belongs to the peptidase S1 family. Kallikrein subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Protease; EC 3.4.21.35

Chromosomal Location of Human Ortholog: 19q13.3

Cellular Component: nucleus

Molecular Function: serine-type endopeptidase activity

Biological Process: proteolysis

Disease: Kallikrein, Decreased Urinary Activity Of
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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