Q9NYG8.2
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
Potassium channel subfamily K member 4
NCBI Official Synonym Full Names
potassium two pore domain channel subfamily K member 4
NCBI Protein Information
potassium channel subfamily K member 4
UniProt Protein Name
Potassium channel subfamily K member 4
UniProt Synonym Protein Names
TWIK-related arachidonic acid-stimulated potassium channel protein
UniProt Synonym Gene Names
NCBI Summary for KCNK4
This gene encodes a member of the TWIK-related arachidonic acid-stimulated two pore potassium channel subfamily. The encoded protein homodimerizes and functions as an outwardly rectifying channel. This channel is regulated by polyunsaturated fatty acids, temperature and mechanical deformation of the lipid membrane. This protein is expressed primarily in neural tissues and may be involved in regulating the noxious input threshold in dorsal root ganglia neurons. Alternate splicing results in multiple transcript variants. Naturally occurring read-through transcripts also exist between this gene and the downstream testis expressed 40 (TEX40) gene, as represented in GeneID: 106780802. [provided by RefSeq, Nov 2015]
UniProt Comments for KCNK4
KCNK4: Voltage insensitive, instantaneous, outwardly rectifying potassium channel. Outward rectification is reversed at high external K(+) concentrations. Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, integral; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 11q13.1
Cellular Component: integral to plasma membrane; plasma membrane
Molecular Function: potassium channel activity
Biological Process: detection of mechanical stimulus involved in sensory perception of touch; potassium ion transport; sensory perception of pain; sensory perception of temperature stimulus
Research Articles on KCNK4
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Products associated with anti-KCNK4 antibody
Pathways associated with anti-KCNK4 antibody
Diseases associated with anti-KCNK4 antibody
Organs/Tissues associated with anti-KCNK4 antibody
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