NP_004691.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
71,196 Da
NCBI Official Full Name
potassium voltage-gated channel subfamily KQT member 4 isoform a
NCBI Official Synonym Full Names
potassium channel, voltage gated KQT-like subfamily Q, member 4
NCBI Protein Information
potassium voltage-gated channel subfamily KQT member 4
UniProt Protein Name
Potassium voltage-gated channel subfamily KQT member 4
UniProt Synonym Protein Names
KQT-like 4; Potassium channel subunit alpha KvLQT4; Voltage-gated potassium channel subunit Kv7.4
UniProt Entry Name
KCNQ4_HUMAN
NCBI Summary for KCNQ4
The protein encoded by this gene forms a potassium channel that is thought to play a critical role in the regulation of neuronal excitability, particularly in sensory cells of the cochlea. The current generated by this channel is inhibited by M1 muscarinic acetylcholine receptors and activated by retigabine, a novel anti-convulsant drug. The encoded protein can form a homomultimeric potassium channel or possibly a heteromultimeric channel in association with the protein encoded by the KCNQ3 gene. Defects in this gene are a cause of nonsyndromic sensorineural deafness type 2 (DFNA2), an autosomal dominant form of progressive hearing loss. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
UniProt Comments for KCNQ4
KCNQ4: Probably important in the regulation of neuronal excitability. May underlie a potassium current involved in regulating the excitability of sensory cells of the cochlea. KCNQ4 channels are blocked by linopirdin, XE991 and bepridil, whereas clofilium is without significant effect. Muscarinic agonist oxotremorine-M strongly suppress KCNQ4 current in CHO cells in which cloned KCNQ4 channels were coexpressed with M1 muscarinnic receptors. Defects in KCNQ4 are the cause of deafness autosomal dominant type 2A (DFNA2A). DFNA2A is a form of sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information. Belongs to the potassium channel family. KQT (TC 1.A.1.15) subfamily. Kv7.4/KCNQ4 sub-subfamily. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, integral; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 1p34
Cellular Component: voltage-gated potassium channel complex; plasma membrane; basal plasma membrane; integral to membrane
Molecular Function: potassium channel activity; delayed rectifier potassium channel activity
Biological Process: synaptic transmission; inner ear morphogenesis; sensory perception of sound; potassium ion transport
Disease: Deafness, Autosomal Dominant 2a
Research Articles on KCNQ4
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Products associated with anti-KCNQ4 antibody
Pathways associated with anti-KCNQ4 antibody
Diseases associated with anti-KCNQ4 antibody
Organs/Tissues associated with anti-KCNQ4 antibody
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