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anti-LEFTY2 antibody :: Rabbit anti-Human LEFTY2 Polyclonal Antibody

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Catalog # MBS7045702
Unit / Price
  0.05 mL  /  $120 +1 FREE 8GB USB
  0.1 mL  /  $160 +1 FREE 8GB USB
Product Name

LEFTY2, Polyclonal Antibody

Popular Item
Also Known As

LEFTY2 Antibody

Product Synonym Names
Left-right determination factor 2; Endometrial bleeding-associated factor; Left-right determination factor A; Protein lefty-2; Protein lefty-A; Transforming growth factor beta-4; TGF-beta-4; LEFTY2; EBAF; LEFTA; LEFTYA; TGFB4; PSEC0024
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Length
332
OMIM
601877
3D Structure
ModBase 3D Structure for O00292
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Purity/Purification
Antigen Affinity Purified
Form/Format
Liquid
Species
Human
Immunogen
Recombinant human Left-right determination factor 2 protein (C-310AA)
Conjugate
Non-conjugated
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Santa Cruz Alternative
Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-7408 / sc-133732 / sc-48836
Preparation and Storage
Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Other Notes
Small volumes of anti-LEFTY2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-LEFTY2 antibody
Required for left-right (L-R) asymmetry determination of organ systems in mammals. May play a role in endometrial bleeding.
Applications Tested/Suitable for anti-LEFTY2 antibody
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)

Western Blot (WB) of anti-LEFTY2 antibody
Western blot
All lanes: LEFTY2 antibody at 2ug/ml+A431 whole cell lysate
Secondary
Goat polyclonal to rabbit at 1/10000 dilution
Predicted band size: 41,38 kDa
Observed band size: 41 kDa

anti-LEFTY2 antibody Western Blot (WB) (WB) image
Immunohistochemistry (IHC) of anti-LEFTY2 antibody
Immunohistochemistry of paraffin-embedded human endometrial cancer using MBS7045702 at dilution 1:100
anti-LEFTY2 antibody Immunohistochemistry (IHC) (IHC) image
Immunohistochemistry (IHC) of anti-LEFTY2 antibody
Immunohistochemistry of paraffin-embedded human colon cancer using MBS7045702 at dilution 1:100
anti-LEFTY2 antibody Immunohistochemistry (IHC) (IHC) image
NCBI/Uniprot data below describe general gene information for LEFTY2. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
37,093 Da
NCBI Official Full Name
left-right determination factor 2 isoform 2
NCBI Official Synonym Full Names
left-right determination factor 2
NCBI Official Symbol
LEFTY2  [Similar Products]
NCBI Official Synonym Symbols
EBAF; LEFTA; TGFB4; LEFTYA
  [Similar Products]
NCBI Protein Information
left-right determination factor 2
UniProt Protein Name
Left-right determination factor 2
UniProt Synonym Protein Names
Endometrial bleeding-associated factor; Left-right determination factor A; Protein lefty-2; Protein lefty-A; Transforming growth factor beta-4; TGF-beta-4
UniProt Gene Name
LEFTY2  [Similar Products]
UniProt Synonym Gene Names
EBAF; LEFTA; LEFTYA; TGFB4; TGF-beta-4  [Similar Products]
UniProt Entry Name
LFTY2_HUMAN
NCBI Summary for LEFTY2
This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate the mature protein, which plays a role in left-right asymmetry determination of organ systems during development. The protein may also play a role in endometrial bleeding. Mutations in this gene have been associated with left-right axis malformations, particularly in the heart and lungs. Some types of infertility have been associated with dysregulated expression of this gene in the endometrium. This gene is closely linked to both a related family member and a related pseudogene. This gene encodes multiple isoforms that may undergo similar proteolytic processing. [provided by RefSeq, Aug 2016]
UniProt Comments for LEFTY2
LEFTY2: Required for left-right (L-R) asymmetry determination of organ systems in mammals. May play a role in endometrial bleeding. Defects in LEFTY2 are the cause of left-right axis malformations (LRAM). The defect includes left pulmonary isomerism, with cardiac anomalies characterized by complete atrioventricular canal defect and hypoplastic left ventricle, and interrupted inferior vena cava. Belongs to the TGF-beta family.

Protein type: Cytokine; Secreted, signal peptide; Secreted; Ligand, receptor tyrosine kinase

Chromosomal Location of Human Ortholog: 1q42.1

Cellular Component: extracellular matrix; extracellular region; extracellular space

Molecular Function: cytokine activity; transforming growth factor beta receptor binding

Biological Process: cell development; platelet degranulation; regulation of apoptosis; regulation of MAPKKK cascade; transforming growth factor beta receptor signaling pathway
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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