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anti-LEP-R antibody :: Rabbit anti-Human Leptin Receptor Polyclonal Antibody

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Catalog # MBS853003
Unit / Price
  0.1 mg  /  $330 +1 FREE 8GB USB
Testing Data
Product Name

Leptin Receptor (LEP-R), Polyclonal Antibody

Also Known As

Leptin Receptor Antibody

Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Length
896
OMIM
601007
3D Structure
ModBase 3D Structure for P48357
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human
Form/Format
Purified by protein A column containing 0.02% NaN3
Preparation and Storage
Already reconstituted in 200ul sterile H2O. The antibody is stable for at least one year when stored at-20 degree C.
Other Notes
Small volumes of anti-LEP-R antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-LEP-R antibody
Rabbit polyclonal Lepti Receptor (1) antibody was raised against a 14 amino acid peptide at the intermediate residues of human Leptin Receptor protein.
Applications Tested/Suitable for anti-LEP-R antibody
Peptide ELISA (EIA), Western Blot (WB)
Application Notes for anti-LEP-R antibody
Peptide ELISA: 1:40,000-1:80,000
WB: 1:500-1:1,000

Testing Data of anti-LEP-R antibody
anti-LEP-R antibody Testing Data image
NCBI/Uniprot data below describe general gene information for LEP-R. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
96,042 Da
NCBI Official Full Name
leptin receptor isoform 3
NCBI Official Synonym Full Names
leptin receptor
NCBI Official Symbol
NCBI Official Synonym Symbols
OBR; OB-R; CD295; LEP-R; LEPRD
  [Similar Products]
NCBI Protein Information
leptin receptor
UniProt Protein Name
Leptin receptor
UniProt Synonym Protein Names
HuB219; OB receptor; OB-R; CD_antigen: CD295
Protein Family
UniProt Gene Name
UniProt Synonym Gene Names
DB; OBR; LEP-R; OB-R  [Similar Products]
NCBI Summary for LEP-R
The protein encoded by this gene belongs to the gp130 family of cytokine receptors that are known to stimulate gene transcription via activation of cytosolic STAT proteins. This protein is a receptor for leptin (an adipocyte-specific hormone that regulates body weight), and is involved in the regulation of fat metabolism, as well as in a novel hematopoietic pathway that is required for normal lymphopoiesis. Mutations in this gene have been associated with obesity and pituitary dysfunction. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. It is noteworthy that this gene and LEPROT gene (GeneID:54741) share the same promoter and the first 2 exons, however, encode distinct proteins (PMID:9207021).[provided by RefSeq, Nov 2010]
UniProt Comments for LEP-R
Receptor for hormone LEP/leptin (Probable) (PubMed:22405007). On ligand binding, mediates LEP central and peripheral effects through the activation of different signaling pathways such as JAK2/STAT3 and MAPK cascade/FOS. In the hypothalamus, LEP acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones () (PubMed:9537324). In the periphery, increases basal metabolism, influences reproductive function, regulates pancreatic beta-cell function and insulin secretion, is pro-angiogenic and affects innate and adaptive immunity (PubMed:25060689, PubMed:12504075, PubMed:8805376). Control of energy homeostasis and melanocortin production (stimulation of POMC and full repression of AgRP transcription) is mediated by STAT3 signaling, whereas distinct signals regulate NPY and the control of fertility, growth and glucose homeostasis. Involved in the regulation of counter-regulatory response to hypoglycemia by inhibiting neurons of the parabrachial nucleus. Has a specific effect on T lymphocyte responses, differentially regulating the proliferation of naive and memory T -ells. Leptin increases Th1 and suppresses Th2 cytokine production ().
Product References and Citations for anti-LEP-R antibody
(1)Koda, M., Sulkowska, M., Wincewicz, A. et, al Expression of leptin, leptin receptor, and hypoxia-inducible factor 1 alpha in human endometrial cancer. Ann. N. Y. Acad. Sci. 2007: 1095, 90-98.

Precautions
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Disclaimer
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